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| 2. |
- Edvinsson, Marie, et al.
(author)
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Persistent Chlamydophila pneumoniae infection in thoracic aortic aneurysm and aortic dissection?
- 2010
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In: Upsala Journal of Medical Sciences. - : Uppsala Medical Society. - 0300-9734 .- 2000-1967. ; 115:3, s. 181-186
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Journal article (peer-reviewed)abstract
- Objectives. Chlamydophila pneumoniae (C. pneumoniae) has been associated with atherosclerosis and abdominal aortic aneurysm and is probably disseminated by peripheral blood mononuclear cells (PBMC). Viable and metabolically active bacteria can be demonstrated by the presence of bacterial mRNA and on-going dissemination by the presence of bacteria in PBMC. The aim of this study was to determine the prevalence of C. pneumoniae DNA and mRNA in aortic biopsies and C. pneumoniae DNA in PBMC in thoracic aortic aneurysm and aortic dissection patients. Design. Real-time PCR was used to detect C. pneumoniae DNA and mRNA in biopsies and C. pneumoniae DNA in PBMC. Results. C. pneumoniae DNA was found in biopsies in 26% (6/23) of aneurysm patients and 11% (2/18) of dissection patients but in none of the forensic autopsy controls. C. pneumoniae mRNA was not found in any biopsy, and all PBMC were C. pneumoniae-negative. Conclusions. Presence of C. pneumoniae DNA but not mRNA in aortic biopsies and no evidence of C. pneumoniae in PBMC suggest that the infection in the aorta has passed into a state of persistence.
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| 3. |
- Edvinsson, Marie, et al.
(author)
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Presence of Chlamydophila pneumoniae DNA but not mRNA in stenotic aortic heart valves
- 2010
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In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 143:1, s. 57-62
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Journal article (peer-reviewed)abstract
- Background: The pathogenesis of aortic valve stenosis may involve inflammation and we have previously demonstrated Chlamydophila pneumoniae (C. pneumoniae) DNA in stenotic aortic heart valves. Dissemination of these bacteria is probably mediated by alveolar macrophages. Bacterial DNA alone does not indicate whether the bacteria are viable and replicating. This study aimed to investigate the presence of C. pneumoniae mRNA, a marker of replicating bacteria, and C. pneumoniae DNA in stenotic aortic valves and the prevalence of C. pneumoniae in peripheral blood mononuclear cells (PBMC).Methods: DNA was extracted from heart valves and PBMC and mRNA from heart valves from 76 patients undergoing aortic valve replacement surgery. C. pneumoniae DNA and mRNA were measured by real-time PCR targeting the ompA gene.Results: C. pneumoniae DNA was demonstrated in 22% of heart valves and in 5% of PBMC. C. pneumoniae mRNA was not detected in any valve. Patients positive for C. pneumoniae in the valve underwent coronary artery by-pass grafting more often (p = 0.01) and suffered from angina pectoris (p = 0.02) and arterial hypertension (p = 0.03) more often than patients negative for C. pneumoniae in the valve.Conclusions: These findings support a role for C. pneumoniae in the pathogenesis of aortic valve stenosis and indicate that the bacteria disseminate from the respiratory tract long before the patients were in need of surgery and that the valve infection thereafter entered into a persistent and non-replicative state. Moreover, patients positive for C. pneumoniae in the valve more often needed by-pass grafting because of more advanced coronary disease.
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| 5. |
- Johansson, Birgitta, et al.
(author)
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Atrial function after left atrial epicardial cryoablation for atrial fibrillation in patients undergoing mitral valve surgery
- 2012
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In: Journal of Interventional Cardiac Electrophysiology. - : Springer Science+Business Media B.V.. - 1383-875X .- 1572-8595. ; 33:1, s. 85-91
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Journal article (peer-reviewed)abstract
- PURPOSE: To explore the effects on atrial and ventricular function of restoring sinus rhythm (SR) after epicardial cryoablation and closure of the left atrial appendage (LAA) in patients with mitral valve disease and atrial fibrillation (AF) undergoing surgery.METHODS: Sixty-five patients with permanent AF were randomized to mitral valve surgery combined with left atrial epicardial cryoablation and LAA closure (ABL group, n = 30) or to mitral valve surgery alone (control group, n = 35). Two-dimensional and Doppler echocardiography were performed before and 6 months after surgery.RESULTS: At 6 months, 73% of the patients in the ABL group and 46% of the controls were in SR. Patients in SR at 6 months had a reduction in their left ventricular diastolic diameter while the left ventricular ejection fraction was unchanged. In patients remaining in AF, the left ventricular ejection fraction was lower than at baseline. The left atrial diastolic volume was reduced after surgery, more in patients with SR than AF. In patients in SR, the peak velocity during the atrial contraction and the reservoir function were lower in the ABL group than in the control group.CONCLUSIONS: In patients in SR, signs of atrial dysfunction were observed in the ABL but not the control group. Atrial dysfunction may have existed before surgery, but the difference between the groups implies that the cryoablation procedure and/or closure of the LAA might have contributed.
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| 6. |
- Thelin, Eva, 1966-
(author)
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Folklig dialektlexikografi 1991–2011
- 2012
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In: Nordiske Studier i Leksikografi, (11). - Lund : Nordiska föreningen för lexikografi. ; , s. 596-609
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Conference paper (peer-reviewed)abstract
- This article investigates Swedish dialect dictionaries published from 1991 to 2011. Generally, these dictionaries have been compiled by lay lexicographers and show the vocabulary of a dialect spoken in one or a few adjacent parishes. Right from the start in the 18th century, the main purpose of publishing dialect dictionaries has been to document dialects and preserve them for posterity. As a consequence, the dialects were always presented as the source language. In 1991, however, a dictionary emerged using standard Swedish as the source language, thereby focusing on the needs of users who wanted to learn the dialect. Twenty years afterwards it can be determined whether this dictionary was an isolated phenomenon or if other similar publications have followed. Out of 115 dictionaries, I have identified 19 which in my opinion tend to learners’ needs in various ways. Quite a few of them treat dialects that are incomprehensible from a standard Swedish perspective. Another apparent change taking place during this period is the development of web-based dictionaries. I have been able to trace 59 presenting Swedish dialects. They differ from print publications in several ways. Two of the most obvious differences, concerning the number of words and the use of illustrations, are addressed and discussed. Somewhat surprising is the discovery that web publishers rarely invite interactivity. Nor do they provide for performing various types of searches or listening to sound samples.
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| 7. |
- Thelin, Eva, 1966-
(author)
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Göta Petter!
- 2014
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Other publication (pop. science, debate, etc.)
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| 8. |
- Thelin, Eva, 1966-
(author)
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Hinsidan
- 2011
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Other publication (pop. science, debate, etc.)
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| 9. |
- Thelin, Eva, 1966-
(author)
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Kuse
- 2010
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Other publication (pop. science, debate, etc.)
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| 10. |
- Thelin, Eva, 1966-
(author)
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Lev och läfsa
- 2014
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Other publication (pop. science, debate, etc.)
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