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- Rugarn, Olof, et al.
(author)
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Effects of estradiol, progesterone, and norethisterone on regional concentrations of galanin in the rat brain
- 1999
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In: Peptides. - 0196-9781 .- 1873-5169. ; 20:6, s. 743-748
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Journal article (peer-reviewed)abstract
- Concentrations of immunoreactive galanin were compared in eight gross brain regions of ovariectomized female rats treated with either estradiol, estradiol + progesterone, estradiol + norethisterone, or placebo. Higher concentrations with estradiol treatment compared with placebo were found in the pituitary (357%), frontal cortex (162%), occipital cortex (174%), hippocampus (170%), and median eminence (202%). A more profound difference with addition of progesterone or norethisterone was seen in the pituitary (529% and 467%, respectively). Sex steroids, particularly estradiol, modulate galanin concentrations not only in reproductive, but also in nonreproductive, brain regions.
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- Rugarn, Olof, et al.
(author)
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Sex differences in neuropeptide distribution in the rat brain
- 1999
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In: Peptides. - 0196-9781 .- 1873-5169. ; 20:1, s. 81-86
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Journal article (peer-reviewed)abstract
- We have investigated possible sex differences in the regional concentrations of neuropeptides in the rat brain. Immunoreactive neurotensin (NT), neurokinin A (NKA), galanin (GAL), calcitonin gene-related peptide (CGRP), substance P (SP) and neuropeptide Y (NPY) were measured by radioimmunoassay in frontal cortex, occipital cortex, hippocampus, striatum, hypothalamus and pituitary in male and female pre- and postpubertal rats. Sex differences were found for NPY (p < 0.001), NT (p < 0.01) and GAL (p < 0.05), in particular in hippocampus, striatum, hypothalamus and pituitary, but not for CGRP, SP and NKA. Results from analysis of neuropeptides in one sex may not be entirely applicable to the other.
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