| 1. |
- Ferreira, Mjv, et al.
(author)
-
Poster Session 3 : Tuesday 5 May 2015, 08
- 2015
-
In: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 16 Suppl 1
-
Journal article (peer-reviewed)
|
|
| 2. |
- Eicher, John D., et al.
(author)
-
Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals
- 2016
-
In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 99:1, s. 40-55
-
Journal article (peer-reviewed)abstract
- Platelet production, maintenance, and clearance are tightly controlled processes indicative of platelets' important roles in hemostasis and thrombosis. Platelets are common targets for primary and secondary prevention of several conditions. They are monitored clinically by complete blood counts, specifically with measurements of platelet count (PLT) and mean platelet volume (MPV). Identifying genetic effects on PLT and MPV can provide mechanistic insights into platelet biology and their role in disease. Therefore, we formed the Blood Cell Consortium (BCX) to perform a large-scale meta-analysis of Exomechip association results for PLT and MPV in 157,293 and 57,617 individuals, respectively. Using the low-frequency/rare coding variant-enriched Exomechip genotyping array, we sought to identify genetic variants associated with PLT and MPV. In addition to confirming 47 known PLT and 20 known MPV associations, we identified 32 PLT and 18 MPV associations not previously observed in the literature across the allele frequency spectrum, including rare large effect (FCER1A), low-frequency (IQGAP2, MAP1A, LY75), and common(ZMIZ2, SMG6, PEAR1, ARFGAP3/PACSIN2) variants. Several variants associated with PLT/MPV(PEAR1, MRVI1, PTGES3) were also associated with platelet reactivity. In concurrent BCX analyses, there was overlap of platelet-associated variants with red (MAP1A, TMPRSS6, ZMIZ2) and white (PEAR1, ZMIZ2, LY75) blood cell traits, suggesting common regulatory pathways with shared genetic architecture among these hematopoietic lineages. Our large-scale Exomechip analyses identified previously undocumented associations with platelet traits and further indicate that several complex quantitative hematological, lipid, and cardiovascular traits share genetic factors.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Bergé, Luc, et al.
(author)
-
THz emissions by two-color filaments in air: Revisiting the wavelength scaling
- 2019
-
In: Optics InfoBase Conference Papers. - 2162-2701. ; Part F134-NLO 2019
-
Conference paper (peer-reviewed)abstract
- We report impressive growths in the terahertz energies supplied by air plasmas created by two-color laser pulses whose fundamental wavelength is increased. Comprehensive 3D simulations reveal the crucial role of the two-color relative phase.
|
|
| 7. |
- Bergé, Luc, et al.
(author)
-
Wavelength scaling of THz emissions by two-color filaments in air
- 2019
-
In: 2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2019. ; June 2019
-
Conference paper (peer-reviewed)abstract
- Producing terahertz (THz) radiation by ultrashort laser pulses has become an active field of research because of its promising applications in, e.g., spectroscopy and medical imaging [1]. Efficient THz emitters can be obtained by focusing into air a two-color femtosecond light pulse, composed of fundamental (FH) and second (SH) harmonics, in order to create a plasma channel that acts as a frequency converter [2]. Recent studies [3,4] showed that increasing the pump wavelength enhances the THz energy. However, there is no consensus on the gain factors expected when pushing the FH wavelength, λ0, from the near-IR to the mid-IR range. Clerici et al. [3] reported THz energy yields scaling like λ20 in the range 0.8-1.8 μm. By contrast, according to the local-current model [2,4], the largest THz energy attained by two colors with π/2 relative phase should follow a scaling in λ20 only.
|
|
| 8. |
- Kaltenecker, K. J., et al.
(author)
-
Plasmonic Resonances Affecting Terahertz Generation in Laser-Induced Gas-Plasmas
- 2018
-
In: International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz. - : Book Series: International Conference on Infrared Millimeter and Terahertz Waves. - 2162-2027 .- 2162-2035. ; 2018-September
-
Conference paper (peer-reviewed)abstract
- We demonstrate that plasmonic resonances can be used to broaden the terahertz emission spectrum from two-color laser-driven gas-plasmas. This effect can be controlled by changing the polarization properties of elliptically shaped driving laser-pulses.
|
|
| 9. |
- Nguyen, Alisée, et al.
(author)
-
Wavelength scaling of terahertz pulse energies delivered by two-color air plasmas
- 2019
-
In: Optics Letters. - 0146-9592 .- 1539-4794. ; 44:6, s. 1488-1491
-
Journal article (peer-reviewed)abstract
- We address the long-standing problem of anomalous growth observed in the terahertz (THz) energy yield from air plasmas created by two-color laser pulses, as the fundamental wavelength λ 0 is increased. Using two distinct optical parametric amplifiers (OPAs), we report THz energies scaling like λ α0 with large exponents 5.6 ≤ α ≤ 14.3, which departs from the growth in λ 20 expected from photocurrent theory. By means of comprehensive 3D simulations, we demonstrate that the changes in the laser beam size, pulse duration, and phase-matching conditions in the second-harmonic generation process when tuning the OPA’s carrier wavelength can lead to these high scaling powers. The value of the phase angle between the two colors reached at the exit of the doubling crystal turns out to be crucial and even explains non-monotonic behaviors in the measurements.
|
|
| 10. |
- Pelet, J. -É, et al.
(author)
-
Don’t believe the hype : a grounded exploratory six country wine purchasing study
- 2017
-
In: Journal of Wine Research. - : Routledge. - 0957-1264 .- 1469-9672. ; 28:2, s. 91-104
-
Journal article (peer-reviewed)abstract
- The purpose of this exploratory study was to understand the extent that consumers report purchasing wine on mobile devices and to empirically examine potential drivers of m-wine purchasing across six countries to guide theoretical research enquiry moving forward. Purposive sampling was employed. An online survey involving 2853 respondents from France, Germany, Greece, Canada, US and South Africa forms the basis for the current study. The results of the study indicate that though mobile phone usage, wine consumption and purchasing rates are high, mobile-wine purchasing prevalence is low within all six countries. While technology hype has us believe an online presence is essential for business revenue growth and performance; the current study indicates wineries should carefully consider consumer readiness towards mobile-wine purchasing. Limitations and recommendations for future research are identified.
|
|
