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Träfflista för sökning "WFRF:(Thomas JO) srt2:(2020-2024)"

Search: WFRF:(Thomas JO) > (2020-2024)

  • Result 1-10 of 57
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1.
  • 2021
  • swepub:Mat__t
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  • Bravo, L, et al. (author)
  • 2021
  • swepub:Mat__t
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  • Tabiri, S, et al. (author)
  • 2021
  • swepub:Mat__t
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  • Glasbey, JC, et al. (author)
  • 2021
  • swepub:Mat__t
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6.
  • Anthon, Carl Thomas, et al. (author)
  • Thrombocytopenia and platelet transfusions in ICU patients : an international inception cohort study (PLOT-ICU)
  • 2023
  • In: Intensive Care Medicine. - 0342-4642. ; 49:11, s. 1327-1338
  • Journal article (peer-reviewed)abstract
    • PURPOSE: Thrombocytopenia (platelet count < 150 × 10 9/L) is common in intensive care unit (ICU) patients and is likely associated with worse outcomes. In this study we present international contemporary data on thrombocytopenia in ICU patients. METHODS: We conducted a prospective cohort study in adult ICU patients in 52 ICUs across 10 countries. We assessed frequencies of thrombocytopenia, use of platelet transfusions and clinical outcomes including mortality. We evaluated pre-selected potential risk factors for the development of thrombocytopenia during ICU stay and associations between thrombocytopenia at ICU admission and 90-day mortality using pre-specified logistic regression analyses.RESULTS: We analysed 1166 ICU patients; the median age was 63 years and 39.5% were female. Overall, 43.2% (95% confidence interval (CI) 40.4-46.1) had thrombocytopenia; 23.4% (20-26) had thrombocytopenia at ICU admission, and 19.8% (17.6-22.2) developed thrombocytopenia during their ICU stay. Absence of acquired immune deficiency syndrome (AIDS), non-cancer-related immune deficiency, liver failure, male sex, septic shock, and bleeding at ICU admission were associated with the development of thrombocytopenia during ICU stay. Among patients with thrombocytopenia, 22.6% received platelet transfusion(s), and 64.3% of in-ICU transfusions were prophylactic. Patients with thrombocytopenia had higher occurrences of bleeding and death, fewer days alive without the use of life-support, and fewer days alive and out of hospital. Thrombocytopenia at ICU admission was associated with 90-day mortality (adjusted odds ratio 1.7; 95% CI 1.19-2.42).CONCLUSION: Thrombocytopenia occurred in 43% of critically ill patients and was associated with worse outcomes including increased mortality. Platelet transfusions were given to 23% of patients with thrombocytopenia and most were prophylactic.
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7.
  • Beal, Jacob, et al. (author)
  • Robust estimation of bacterial cell count from optical density
  • 2020
  • In: Communications Biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 3:1
  • Journal article (peer-reviewed)abstract
    • Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.
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  • Result 1-10 of 57
Type of publication
journal article (49)
research review (3)
conference paper (1)
Type of content
peer-reviewed (49)
other academic/artistic (4)
Author/Editor
Negoi, I (16)
Rahim, F (12)
Lee, M (11)
Abreu, LG (11)
Al-Aly, Z (11)
Ali, M (11)
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Aljunid, SM (11)
Alvis-Guzman, N (11)
Andrei, CL (11)
Arabloo, J (11)
Ausloos, M (11)
Basu, S (11)
Butt, ZA (11)
Diaz, D (11)
Duraes, AR (11)
Fereshtehnejad, SM (11)
Fischer, F (11)
Folayan, MO (11)
Hasaballah, AI (11)
Hay, SI (11)
Hosseinzadeh, M (11)
Ilic, MD (11)
Jonas, JB (11)
Kabir, Z (11)
Kisa, A (11)
Kisa, S (11)
Krishan, K (11)
La Vecchia, C (11)
Lasrado, S (11)
Lee, PH (11)
Mansournia, MA (11)
Martins-Melo, FR (11)
Menezes, RG (11)
Meretoja, TJ (11)
Miller, TR (11)
Mirrakhimov, EM (11)
Mohammed, S (11)
Mokdad, AH (11)
Moraga, P (11)
Nagarajan, AJ (11)
Olagunju, AT (11)
Olusanya, BO (11)
Olusanya, JO (11)
Onwujekwe, OE (11)
Owolabi, MO (11)
Pepito, VCF (11)
Postma, MJ (11)
Prada, SI (11)
Rahman, MA (11)
Ranabhat, CL (11)
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University
Karolinska Institutet (28)
Uppsala University (15)
University of Gothenburg (14)
Lund University (14)
Malmö University (6)
Högskolan Dalarna (6)
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Linköping University (4)
Umeå University (3)
Royal Institute of Technology (3)
Stockholm University (3)
Stockholm School of Economics (3)
Örebro University (2)
Chalmers University of Technology (1)
Swedish University of Agricultural Sciences (1)
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Language
English (57)
Research subject (UKÄ/SCB)
Medical and Health Sciences (37)
Natural sciences (8)
Social Sciences (8)
Humanities (2)

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