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Search: WFRF:(Unge Torsten) > (1995-1999)

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  • Bäckbro, Kristina, et al. (author)
  • Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor
  • 1997
  • In: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 40:6, s. 898-902
  • Journal article (peer-reviewed)abstract
    • Two cyclic, C2-symmetric HIV-1 protease inhibitors, one sulfamide and one urea derivative, both comprising phenyl ether groups in the P1/P1‘ positions, were cocrystallized with HIV-1 protease, and the crystal structures were determined to 2.0 Å resolution. The structure of the urea 2 showed a conformation similar to that reported for the related urea 3 by Lam et al., while the sulfamide 1 adopted an unanticipated conformation in which the P1‘ and P2‘ side chains were transposed.
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