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Träfflista för sökning "WFRF:(Vajda N.) srt2:(2015-2019)"

Search: WFRF:(Vajda N.) > (2015-2019)

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1.
  • Kehoe, Laura, et al. (author)
  • Make EU trade with Brazil sustainable
  • 2019
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
  • Journal article (other academic/artistic)
  •  
2.
  • Fountoulakis, Konstantinos N., et al. (author)
  • Staging of Schizophrenia With the Use of PANSS : An International Multi-Center Study
  • 2019
  • In: International Journal of Neuropsychopharmacology. - : Oxford University Press. - 1461-1457 .- 1469-5111. ; 22:11, s. 681-697
  • Journal article (peer-reviewed)abstract
    • IntroductionA specific clinically relevant staging model for schizophrenia has not yet been developed. The aim of the current study was to evaluate the factor structure of the PANSS and develop such a staging method.MethodsTwenty-nine centers from 25 countries contributed 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Analysis of covariance, Exploratory Factor Analysis, Discriminant Function Analysis, and inspection of resultant plots were performed.ResultsExploratory Factor Analysis returned 5 factors explaining 59% of the variance (positive, negative, excitement/hostility, depression/anxiety, and neurocognition). The staging model included 4 main stages with substages that were predominantly characterized by a single domain of symptoms (stage 1: positive; stages 2a and 2b: excitement/hostility; stage 3a and 3b: depression/anxiety; stage 4a and 4b: neurocognition). There were no differences between sexes. The Discriminant Function Analysis developed an algorithm that correctly classified >85% of patients.DiscussionThis study elaborates a 5-factor solution and a clinical staging method for patients with schizophrenia. It is the largest study to address these issues among patients who are more likely to remain affiliated with mental health services for prolonged periods of time.
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3.
  • van Rheenen, Wouter, et al. (author)
  • Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
  • 2016
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 48:9, s. 1043-1048
  • Journal article (peer-reviewed)abstract
    • To elucidate the genetic architecture of amyotrophic lateral sclerosis (ALS) and find associated loci, we assembled a custom imputation reference panel from whole-genome-sequenced patients with ALS and matched controls (n = 1,861). Through imputation and mixed-model association analysis in 12,577 cases and 23,475 controls, combined with 2,579 cases and 2,767 controls in an independent replication cohort, we fine-mapped a new risk locus on chromosome 21 and identified C21orf2 as a gene associated with ALS risk. In addition, we identified MOBP and SCFD1 as new associated risk loci. We established evidence of ALS being a complex genetic trait with a polygenic architecture. Furthermore, we estimated the SNP-based heritability at 8.5%, with a distinct and important role for low-frequency variants (frequency 1-10%). This study motivates the interrogation of larger samples with full genome coverage to identify rare causal variants that underpin ALS risk.
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  • Result 1-3 of 3
Type of publication
journal article (3)
Type of content
peer-reviewed (2)
other academic/artistic (1)
Author/Editor
Padovani, Alessandro (1)
Rothhaupt, Karl-Otto (1)
Berk, Michael (1)
Andersen, Peter M. (1)
Al-Chalabi, Ammar (1)
Shatunov, Aleksey (1)
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Jones, Ashley R. (1)
D'Alfonso, Sandra (1)
Dragioti, Elena, Ph. ... (1)
Weigend, Maximilian (1)
Farrell, Katharine N ... (1)
Fogh, Isabella (1)
van Damme, Philip (1)
Corcia, Philippe (1)
Hardiman, Orla (1)
Silani, Vincenzo (1)
Ticozzi, Nicola (1)
Veldink, Jan H. (1)
van den Berg, Leonar ... (1)
de Carvalho, Mamede (1)
Pinto, Susana (1)
Weber, Markus (1)
Shaw, Christopher E. (1)
Shaw, Pamela J. (1)
Morrison, Karen E. (1)
Landers, John E. (1)
Glass, Jonathan D. (1)
Vourc’h, Patrick (1)
Breen, Gerome (1)
Islar, Mine (1)
Krause, Torsten (1)
Uddling, Johan, 1972 (1)
Alexanderson, Helena (1)
Schneider, Christoph (1)
Battiston, Roberto (1)
Lukic, Marko (1)
Pereira, Laura (1)
Riggi, Laura (1)
Cattaneo, Claudio (1)
Jung, Martin (1)
Andresen, Louise C. (1)
Kasimir, Åsa (1)
Wang-Erlandsson, Lan (1)
Sutherland, William ... (1)
Boonstra, Wiebren J. (1)
Kasper, Siegfried (1)
Vajda, Vivi (1)
van Rheenen, Wouter (1)
Ratti, Antonia (1)
Chandran, Siddhartha ... (1)
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University
Umeå University (1)
Royal Institute of Technology (1)
Linköping University (1)
Lund University (1)
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Chalmers University of Technology (1)
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Swedish University of Agricultural Sciences (1)
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Language
English (3)
Research subject (UKÄ/SCB)
Medical and Health Sciences (2)
Natural sciences (1)
Engineering and Technology (1)
Social Sciences (1)

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