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1.	Långström, B., et al. (author) New perspectives of developing PET tracers - an example the imaging of amyloid plaques 2003 In: ISMRM, Bordeaux, France. Conference paper (other academic/artistic)
2.	Långström, B., et al. (author) Positron Emitting Tracers as tools in drug development - technique and applications 2003 In: Swiis Societey for Pharmacology and Toxicology, Autum meeting. Conference paper (other academic/artistic)
3.	Alhuseinalkhudhur, A, et al. (author) Ga-68-ABY-025 PET Predicts the Metabolic Response in Breast Cancer Patients: Preliminary Results From a Phase II Study 2021 In: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. - 1619-7070. ; 48:SUPPL 1, s. S300-S300 Conference paper (other academic/artistic)
4.	Alhuseinalkhudhur, A, et al. (author) HER2-targeting [68Ga]Ga-ABY-025 PET Predicts Early Metabolic Response in Metastatic Breast Cancer 2023 In: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. - 1619-7070. ; 50:SUPPL 1, s. S264-S264 Conference paper (other academic/artistic)
5.	Eriksson, Olof, et al. (author) Assessment of glucagon receptor occupancy by Positron Emission Tomography in non-human primates 2019 In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1, s. 14960- Journal article (peer-reviewed)abstract The glucagon receptor (GCGR) is an emerging target in anti-diabetic therapy. Reliable biomarkers for in vivo activity on the GCGR, in the setting of dual glucagon-like peptide 1/glucagon (GLP-1/GCG) receptor agonism, are currently unavailable. Here, we investigated [68Ga]Ga-DO3A-S01-GCG as a biomarker for GCGR occupancy in liver, the tissue with highest GCGR expression, in non-human primates (NHP) by PET. [68Ga]Ga-DO3A-S01-GCG was evaluated by dynamic PET in NHPs by a dose escalation study design, where up to 67 µg/kg DO3A-S01-GCG peptide mass was co-injected. The test-retest reproducibility of [68Ga]Ga-DO3A-S01-GCG binding in liver was evaluated. Furthermore, we investigated the effect of pre-treatment with acylated glucagon agonist 1-GCG on [68Ga]Ga-DO3A-S01-GCG binding in liver. [68Ga]Ga-DO3A-S01-GCG bound to liver in vivo in a dose-dependent manner. Negligible peptide mass effect was observed for DO3A-S01-GCG doses <0.2 µg/kg. In vivo Kd for [68Ga]Ga-DO3A-S01-GCG corresponded to 0.7 µg/kg, which indicates high potency. The test-retest reproducibility for [68Ga]Ga-DO3A-S01-GCG binding in liver was 5.7 ± 7.9%. Pre-treatment with 1-GCG, an acylated glucagon agonist, resulted in a GCGR occupancy of 61.5 ± 9.1% in liver. Predicted human radiation dosimetry would allow for repeated annual [68Ga]Ga-DO3A-S01-GCG PET examinations. In summary, PET radioligand [68Ga]Ga-DO3A-S01-GCG is a quantitative biomarker of in vivo GCGR occupancy.
6.	Eriksson, Oskar, 1984-, et al. (author) First-in-class PET tracer for the glucagon receptor 2017 In: Diabetologia. - 0012-186X .- 1432-0428. ; 60, s. S400-S400 Journal article (other academic/artistic)
7.	Haylock, A., et al. (author) Generation and evaluation of single chain fragments for molecular imaging of CD44v6-expressing cancers 2017 In: European Journal of Nuclear Medicine and Molecular Imaging. - : Springer. - 1619-7070 .- 1619-7089. ; 44, s. S553-S554 Journal article (other academic/artistic)
8.	Långström, B., et al. (author) The use of Positron Emitting Tracers as a tool in drug development - chemistry perspectives 2003 In: Norsk Kjemisk Selskap Höst möte, Oslo. Conference paper (other academic/artistic)
9.	Långström, B., et al. (author) The use of Positron Emitting Tracers as a tool in drug development - techniques and applications 2003 In: Swiss Pharmacology and Toxicology Meeting, Basel. Conference paper (other academic/artistic)
10.	Selvaraju, Ram Kumar, et al. (author) Pancreatic uptake of [68Ga]DO3A-Exendin4 is mediated by the GLP-1 receptor 2012 In: European Journal of Nuclear Medicine and Molecular Imaging. - 1619-7070 .- 1619-7089. ; 39:S2, s. S195-S195 Journal article (other academic/artistic)

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Result 1-10 of 16

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Type of publication: conference paper (8); journal article (8)

Type of content: other academic/artistic (12); peer-reviewed (4)

Author/Editor: Velikyan, I (12); Bergström, M (5); Långström, B. (5); Antoni, Gunnar (4); Kihlberg, T. (4); Engler, H (4); show more...; Estrada, S (4); Sorensen, J (3); Johansson, L (3); Wagner, M. (3); Eriksson, Olof (3); Velikyan, Irina, 196 ... (3); Awad, R (3); Acharya, S (2); Chattopadhyaya, J (2); Trifonova, A (2); Hartman, J (2); Lindman, H (2); Frejd, FY (2); Lubberink, M (2); Alhuseinalkhudhur, A (2); Iyer, V (2); Liss, P (2); Sundin, T (2); Savitcheva, I (2); Höglund, U. (2); Koivisto, P. (2); Blomqvist, G (2); Johansson, Lars (1); Wu, Z. (1); Korsgren, Olle (1); Eriksson, B (1); Halldin, C (1); Tolmachev, V. (1); Földesi, A (1); Foldesi, A (1); Feldwisch, J (1); Langstrom, B (1); Långström, Bengt (1); Velikyan, Irina (1); Ronnlund, C (1); Selvaraju, Ram Kumar (1); Sörensen, J (1); Carlsson, Per-Ola (1); Sundin, A (1); Takano, A (1); Antoni, G (1); Bergstrom, M (1); Lundqvist, H (1); Nestor, M (1); show less...

University: Uppsala University (12); Karolinska Institutet (5); Royal Institute of Technology (1)

Language: English (15); Undefined language (1)

Research subject (UKÄ/SCB): Natural sciences (6); Medical and Health Sciences (4)

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