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- Aad, G, et al.
(author)
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- 2015
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swepub:Mat__t
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| 7. |
- Shaw, DE, et al.
(author)
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Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
- 2015
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In: The European respiratory journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 46:5, s. 1308-1321
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Journal article (peer-reviewed)abstract
- U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach.This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements.Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12 months; p<0.001), with worse quality of life, and higher levels of anxiety and depression. They also had a higher incidence of nasal polyps and gastro-oesophageal reflux with lower lung function. Sputum eosinophil count was higher in severe asthma compared to mild/moderate asthma (median count 2.99% versus 1.05%; p=0.004) despite treatment with higher doses of inhaled and/or oral corticosteroids.Consistent with other severe asthma cohorts, U-BIOPRED is characterised by poor symptom control, increased comorbidity and airway inflammation, despite high levels of treatment. It is well suited to identify asthma phenotypes using the array of “omic” datasets that are at the core of this systems medicine approach.
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| 9. |
- Benn, J., et al.
(author)
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Currents and Finite Elements as Tools for Shape Space
- 2019
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In: Journal of Mathematical Imaging and Vision. - : Springer Science and Business Media LLC. - 0924-9907 .- 1573-7683. ; 61:8, s. 1197-1220
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Journal article (peer-reviewed)abstract
- The nonlinear spaces of shapes (unparameterized immersed curves or submanifolds) are of interest for many applications in image analysis, such as the identification of shapes that are similar modulo the action of some group. In this paper, we study a general representation of shapes as currents, which are based on linear spaces and are suitable for numerical discretization, being robust to noise. We develop the theory of currents for shape spaces by considering both the analytic and numerical aspects of the problem. In particular, we study the analytical properties of the current map and the norm that it induces on shapes. We determine the conditions under which the current determines the shape. We then provide a finite element-based discretization of the currents that is a practical computational tool for shapes. Finally, we demonstrate this approach on a variety of examples.
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| 10. |
- McLachlan, R.I., et al.
(author)
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B-series methods are exactly the affine equivariant methods
- 2016
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In: Numerische Mathematik. - : Springer Science and Business Media LLC. - 0029-599X .- 0945-3245. ; 133:3, s. 599-622
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Journal article (peer-reviewed)abstract
- Butcher series, also called B-series, are a type of expansion, fundamental in the analysis of numerical integration. Numerical methods that can be expanded in B-series are defined in all dimensions, so they correspond to sequences of maps—one map for each dimension. A long-standing problem has been to characterise those sequences of maps that arise from B-series. This problem is solved here: we prove that a sequence of smooth maps between vector fields on affine spaces has a B-series expansion if and only if it is affine equivariant, meaning it respects all affine maps between affine spaces.
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