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Träfflista för sökning "WFRF:(Vibeke B) srt2:(2010-2014)"

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1.	Berge, Tone, et al. (author) T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells 2010 In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 5:3, s. e9761- Journal article (peer-reviewed)abstract BACKGROUND: The chemokine CXCL12/SDF-1alpha interacts with its G-protein coupled receptor CXCR4 to induce migration of lymphoid and endothelial cells. T cell specific adapter protein (TSAd) has been found to promote migration of Jurkat T cells through interaction with the G protein beta subunit. However, the molecular mechanisms for how TSAd influences cellular migration have not been characterized in detail. PRINCIPAL FINDINGS: We show that TSAd is required for tyrosine phosphorylation of the Lck substrate IL2-inducible T cell kinase (Itk). Presence of Itk Y511 was necessary to boost TSAd's effect on CXCL12 induced migration of Jurkat T cells. In addition, TSAd's ability to promote CXCL12-induced actin polymerization and migration of Jurkat T lymphocytes was dependent on the Itk-interaction site in the proline-rich region of TSAd. Furthermore, TSAd-deficient murine thymocytes failed to respond to CXCL12 with increased Itk phosphorylation, and displayed reduced actin polymerization and cell migration responses. CONCLUSION: We propose that TSAd, through its interaction with both Itk and Lck, primes Itk for Lck mediated phosphorylation and thereby regulates CXCL12 induced T cell migration and actin cytoskeleton rearrangements.
2.	Radford-Smith, Graham, et al. (author) Clinical and molecular characterization of medically refractory acute, severe colitis : preliminary results from the international inflammatory bowel disease genetics consortium (IIBDGC) immunochip study 2013 In: Gastroenterology. - 0016-5085 .- 1528-0012. ; 144:5, s. S470-S470 Journal article (other academic/artistic)

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Type of publication: journal article (2)

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Claesson-Welsh, Lena (1); Halfvarson, Jonas, 1 ... (1); Colombel, Jean-Frede ... (1); Ahmad, Tariq (1); Vermeire, Severine (1); Andersen, Vibeke (1); show more...; Spurkland, Anne (1); Berge, Tone (1); Sundvold-Gjerstad, V ... (1); Granum, Stine (1); Andersen, Thorny C. (1); Holthe, Gunn B. (1); Andreotti, Amy H. (1); Inngjerdingen, Marit (1); Kupcinskas, Limas (1); Silverberg, Mark S. (1); Schumm, L. Philip (1); Annese, Vito (1); Brand, Stephan (1); Brant, Steven R. (1); Gearry, Richard B. (1); Hov, Johannes R. (1); Lawrance, Ian C. (1); Weersma, Rinse K. (1); Radford-Smith, Graha ... (1); Lees, Charlie W. (1); McGovern, Dermot P. (1); Doecke, James D. (1); Krishnaprasad, Krupa (1); show less...

University: Uppsala University (1); Örebro University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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