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Träfflista för sökning "WFRF:(Vicari Marco) srt2:(2023)"

Search: WFRF:(Vicari Marco) > (2023)

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  • Sountoulidis, Alexandros, et al. (author)
  • A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung
  • 2023
  • In: Nature Cell Biology. - : Springer Nature. - 1465-7392 .- 1476-4679.
  • Journal article (peer-reviewed)abstract
    • Sountoulidis et al. provide a spatial gene expression atlas of human embryonic lung during the first trimester of gestation and identify 83 cell identities corresponding to stable cell types or transitional states. The lung contains numerous specialized cell types with distinct roles in tissue function and integrity. To clarify the origins and mechanisms generating cell heterogeneity, we created a comprehensive topographic atlas of early human lung development. Here we report 83 cell states and several spatially resolved developmental trajectories and predict cell interactions within defined tissue niches. We integrated single-cell RNA sequencing and spatially resolved transcriptomics into a web-based, open platform for interactive exploration. We show distinct gene expression programmes, accompanying sequential events of cell differentiation and maturation of the secretory and neuroendocrine cell types in proximal epithelium. We define the origin of airway fibroblasts associated with airway smooth muscle in bronchovascular bundles and describe a trajectory of Schwann cell progenitors to intrinsic parasympathetic neurons controlling bronchoconstriction. Our atlas provides a rich resource for further research and a reference for defining deviations from homeostatic and repair mechanisms leading to pulmonary diseases.
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2.
  • Vicari, Marco, et al. (author)
  • Spatial multimodal analysis of transcriptomes and metabolomes in tissues
  • 2023
  • In: Nature Biotechnology. - 1087-0156 .- 1546-1696.
  • Journal article (peer-reviewed)abstract
    • We present a spatial omics approach that combines histology, mass spectrometry imaging and spatial transcriptomics to facilitate precise measurements of mRNA transcripts and low-molecular-weight metabolites across tissue regions. The workflow is compatible with commercially available Visium glass slides. We demonstrate the potential of our method using mouse and human brain samples in the context of dopamine and Parkinson’s disease.
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