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Träfflista för sökning "WFRF:(Vollenweider P.) srt2:(2010-2014)"

Search: WFRF:(Vollenweider P.) > (2010-2014)

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  • Walters, R G, et al. (author)
  • A new highly penetrant form of obesity due to deletions on chromosome 16p11.2.
  • 2010
  • In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 463:7281, s. 671-5
  • Journal article (peer-reviewed)abstract
    • Obesity has become a major worldwide challenge to public health, owing to an interaction between the Western 'obesogenic' environment and a strong genetic contribution. Recent extensive genome-wide association studies (GWASs) have identified numerous single nucleotide polymorphisms associated with obesity, but these loci together account for only a small fraction of the known heritable component. Thus, the 'common disease, common variant' hypothesis is increasingly coming under challenge. Here we report a highly penetrant form of obesity, initially observed in 31 subjects who were heterozygous for deletions of at least 593 kilobases at 16p11.2 and whose ascertainment included cognitive deficits. Nineteen similar deletions were identified from GWAS data in 16,053 individuals from eight European cohorts. These deletions were absent from healthy non-obese controls and accounted for 0.7% of our morbid obesity cases (body mass index (BMI) >or= 40 kg m(-2) or BMI standard deviation score >or= 4; P = 6.4 x 10(-8), odds ratio 43.0), demonstrating the potential importance in common disease of rare variants with strong effects. This highlights a promising strategy for identifying missing heritability in obesity and other complex traits: cohorts with extreme phenotypes are likely to be enriched for rare variants, thereby improving power for their discovery. Subsequent analysis of the loci so identified may well reveal additional rare variants that further contribute to the missing heritability, as recently reported for SIM1 (ref. 3). The most productive approach may therefore be to combine the 'power of the extreme' in small, well-phenotyped cohorts, with targeted follow-up in case-control and population cohorts.
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  • Heid, Iris M, et al. (author)
  • Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
  • 2010
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 949-960
  • Journal article (peer-reviewed)abstract
    • Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
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  • Result 1-10 of 35
Type of publication
journal article (34)
conference paper (1)
Type of content
peer-reviewed (35)
Author/Editor
Vollenweider, Peter (22)
Wareham, Nicholas J. (18)
Loos, Ruth J F (18)
Campbell, Harry (16)
Rudan, Igor (16)
Wilson, James F. (16)
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Hofman, Albert (16)
Hayward, Caroline (16)
van Duijn, Cornelia ... (15)
Shuldiner, Alan R. (15)
Pramstaller, Peter P ... (15)
Rivadeneira, Fernand ... (15)
Uitterlinden, André ... (15)
Gudnason, Vilmundur (15)
Ferrucci, Luigi (15)
Luan, Jian'an (14)
Harris, Tamara B (14)
Tanaka, Toshiko (14)
Vollenweider, P. (13)
Wichmann, H. Erich (13)
Wright, Alan F. (13)
Zhao, Jing Hua (13)
Psaty, Bruce M (13)
Wild, Sarah H (13)
Boerwinkle, Eric (13)
Prokopenko, Inga (13)
Groop, Leif (12)
Mangino, Massimo (12)
Oostra, Ben A. (12)
Gieger, Christian (12)
Gyllensten, Ulf (12)
Metspalu, Andres (12)
Polasek, Ozren (12)
Illig, Thomas (12)
Teumer, Alexander (12)
Sanna, Serena (12)
Salomaa, Veikko (11)
Soranzo, Nicole (11)
Chasman, Daniel I. (11)
Ingelsson, Erik (11)
Stefansson, Kari (11)
Willemsen, Gonneke (11)
Boomsma, Dorret I. (11)
Jarvelin, Marjo-Riit ... (11)
Hicks, Andrew A. (11)
Johnson, Toby (11)
Pouta, Anneli (11)
Vitart, Veronique (11)
Isaacs, Aaron (11)
Esko, Tõnu (11)
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University
Uppsala University (24)
Karolinska Institutet (22)
Lund University (17)
University of Gothenburg (9)
Umeå University (7)
Högskolan Dalarna (1)
Language
English (34)
French (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (22)
Natural sciences (2)

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