| 1. |
- Faatz, B., et al.
(författare)
-
Simultaneous operation of two soft x-ray free-electron lasers driven by one linear accelerator
- 2016
-
Ingår i: New Journal of Physics. - : IOP Publishing. - 1367-2630. ; 18
-
Tidskriftsartikel (refereegranskat)abstract
- Extreme-ultraviolet to x-ray free-electron lasers (FELs) in operation for scientific applications are up to now single-user facilities. While most FELs generate around 100 photon pulses per second, FLASH at DESY can deliver almost two orders of magnitude more pulses in this time span due to its superconducting accelerator technology. This makes the facility a prime candidate to realize the next step in FELs-dividing the electron pulse trains into several FEL lines and delivering photon pulses to several users at the same time. Hence, FLASH has been extended with a second undulator line and self-amplified spontaneous emission (SASE) is demonstrated in both FELs simultaneously. FLASH can now deliver MHz pulse trains to two user experiments in parallel with individually selected photon beam characteristics. First results of the capabilities of this extension are shown with emphasis on independent variation of wavelength, repetition rate, and photon pulse length.
|
|
| 2. |
- Kehoe, Laura, et al.
(författare)
-
Make EU trade with Brazil sustainable
- 2019
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
|
|
| 3. |
- Sprovieri, F., et al.
(författare)
-
Atmospheric mercury concentrations observed at ground-based monitoring sites globally distributed in the framework of the GMOS network
- 2016
-
Ingår i: Atmospheric Chemistry and Physics. - : Copernicus GmbH. - 1680-7316 .- 1680-7324. ; 16:18, s. 11915-11935
-
Tidskriftsartikel (refereegranskat)abstract
- Long-term monitoring of data of ambient mercury (Hg) on a global scale to assess its emission, transport, atmospheric chemistry, and deposition processes is vital to understanding the impact of Hg pollution on the environment. The Global Mercury Observation System (GMOS) project was funded by the European Commission (http://www.gmos.eu) and started in November 2010 with the overall goal to develop a coordinated global observing system to monitor Hg on a global scale, including a large network of ground-based monitoring stations, ad hoc periodic oceanographic cruises and measurement flights in the lower and upper troposphere as well as in the lower stratosphere. To date, more than 40 ground-based monitoring sites constitute the global network covering many regions where little to no observational data were available before GMOS. This work presents atmospheric Hg concentrations recorded worldwide in the framework of the GMOS project (2010-2015), analyzing Hg measurement results in terms of temporal trends, seasonality and comparability within the network. Major findings highlighted in this paper include a clear gradient of Hg concentrations between the Northern and Southern hemispheres, confirming that the gradient observed is mostly driven by local and regional sources, which can be anthropogenic, natural or a combination of both.
|
|
| 4. |
- Wittkowski, M., et al.
(författare)
-
Aperture synthesis imaging of the carbon AGB star R Sculptoris: Detection of a complex structure and a dominating spot on the stellar disk
- 2017
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 601
-
Tidskriftsartikel (refereegranskat)abstract
- Aims. We present near-infrared interferometry of the carbon-rich asymptotic giant branch (AGB) star R Sculptoris (R Scl). Methods. We employ medium spectral resolution K-band interferometry obtained with the instrument AMBER at the Very Large Telescope Interferometer (VLTI) and H-band low spectral resolution interferometric imaging observations obtained with the VLTI instrument PIONIER. We compare our data to a recent grid of dynamic atmosphere and wind models. We compare derived fundamental parameters to stellar evolution models. Results. The visibility data indicate a broadly circular resolved stellar disk with a complex substructure. The observed AMBER squared visibility values show drops at the positions of CO and CN bands, indicating that these lines form in extended layers above the photosphere. The AMBER visibility values are best fit by a model without a wind. The PIONIER data are consistent with the same model. We obtain a Rosseland angular diameter of 8.9 ± 0.3 mas, corresponding to a Rosseland radius of 355 ± 55 R?, an effective temperature of 2640 ± 80 K, and a luminosity of log L/L? = 3.74 ± 0.18. These parameters match evolutionary tracks of initial mass 1.5 ± 0.5 M? and current mass 1.3 ± 0.7 M?. The reconstructed PIONIER images exhibit a complex structure within the stellar disk including a dominant bright spot located at the western part of the stellar disk. The spot has an H-band peak intensity of 40% to 60% above the average intensity of the limb-darkening-corrected stellar disk. The contrast between the minimum and maximum intensity on the stellar disk is about 1:2.5. Conclusions. Our observations are broadly consistent with predictions by dynamic atmosphere and wind models, although models with wind appear to have a circumstellar envelope that is too extended compared to our observations. The detected complex structure within the stellar disk is most likely caused by giant convection cells, resulting in large-scale shock fronts, and their effects on clumpy molecule and dust formation seen against the photosphere at distances of 2-3 stellar radii. © ESO, 2017.
|
|
| 5. |
- Kraus, Stefan, et al.
(författare)
-
Planet Formation Imager (PFI) : Science vision and key requirements
- 2016
-
Ingår i: Optical and Infrared Interferometry and Imaging V. - : SPIE. - 9781510601932 ; 9907
-
Konferensbidrag (refereegranskat)abstract
- The Planet Formation Imager (PFI) project aims to provide a strong scientific vision for ground-based optical astronomy beyond the upcoming generation of Extremely Large Telescopes. We make the case that a breakthrough in angular resolution imaging capabilities is required in order to unravel the processes involved in planet formation. PFI will be optimised to provide a complete census of the protoplanet population at all stellocentric radii and over the age range from 0.1 to ∼100 Myr. Within this age period, planetary systems undergo dramatic changes and the final architecture of planetary systems is determined. Our goal is to study the planetary birth on the natural spatial scale where the material is assembled, which is the "Hill Sphere" of the forming planet, and to characterise the protoplanetary cores by measuring their masses and physical properties. Our science working group has investigated the observational characteristics of these young protoplanets as well as the migration mechanisms that might alter the system architecture. We simulated the imprints that the planets leave in the disk and study how PFI could revolutionise areas ranging from exoplanet to extragalactic science. In this contribution we outline the key science drivers of PFI and discuss the requirements that will guide the technology choices, the site selection, and potential science/technology tradeoffs.
|
|
| 6. |
- Martelotto, L. G., et al.
(författare)
-
Genomic landscape of adenoid cystic carcinoma of the breast
- 2015
-
Ingår i: Journal of Pathology. - : Wiley. - 0022-3417. ; 237:2, s. 179-189
-
Tidskriftsartikel (refereegranskat)abstract
- Adenoid cystic carcinoma (AdCC) is a rare type of triple-negative breast cancer (TNBC) characterized by the presence of the MYB-NFIB fusion gene. The molecular underpinning of breast AdCCs other than the MYB-NFIB fusion gene remains largely unexplored. Here we sought to define the repertoire of somatic genetic alterations of breast AdCCs. We performed whole-exome sequencing, followed by orthogonal validation, of 12 breast AdCCs to determine the landscape of somatic mutations and gene copy number alterations. Fluorescence in situ hybridization and reverse-transcription PCR were used to define the presence of MYB gene rearrangements and MYB-NFIB chimeric transcripts. Unlike common forms of TNBC, we found that AdCCs have a low mutation rate (0.27 non-silent mutations/Mb), lack mutations in TP53 and PIK3CA and display a heterogeneous constellation of known cancer genes affected by somatic mutations, including MYB, BRAF, FBXW7, SMARCA5, SF3B1 and FGFR2. MYB and TLN2 were affected by somatic mutations in two cases each. Akin to salivary gland AdCCs, breast AdCCs were found to harbour mutations targeting chromatin remodelling, cell adhesion, RNA biology, ubiquitination and canonical signalling pathway genes. We observed that, although breast AdCCs had rather simple genomes, they likely display intra-tumour genetic heterogeneity at diagnosis. Taken together, these findings demonstrate that the mutational burden and mutational repertoire of breast AdCCs are more similar to those of salivary gland AdCCs than to those of other types of TNBCs, emphasizing the importance of histological subtyping of TNBCs. Furthermore, our data provide direct evidence that AdCCs harbour a distinctive mutational landscape and genomic structure, irrespective of the disease site of origin. Copyright (c) 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
|
|
