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Träfflista för sökning "WFRF:(Werner D.) srt2:(1995-1999)"

Search: WFRF:(Werner D.) > (1995-1999)

  • Result 1-8 of 8
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2.
  • CRISTANCHO, F, et al. (author)
  • MULTIPLE SUPERDEFORMED BANDS IN SR-81
  • 1995
  • In: Physics Letters B. - 0370-2693 .- 1873-2445. ; 357:3, s. 281-286
  • Journal article (peer-reviewed)abstract
    • Four superdeformed bands extending over five to twelve transitions have been identified in Sr-81 from a study With the Gammasphere array and the Microball charged-particle array, One of the bands shows an upbend in the dynamic moment of inertia at a rotational frequency of 1.2 MeV and all bands exhibit a nearly constant moment of inertia below that frequency.
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3.
  • Ohlsson, Claes, 1965, et al. (author)
  • p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1.
  • 1998
  • In: Endocrinology. - 0013-7227. ; 139:3, s. 1101-7
  • Journal article (peer-reviewed)abstract
    • The insulin-like growth factor-I receptor (IGF-IR) is involved in tumorigenesis. The aim of the present study was to investigate whether the IGF-IR is a physiological target for p53 in osteosarcoma cells. The p53-induced regulation of IGF-IR levels was studied in a tetracycline-regulated expression system. When expressed in Saos-2, osteosarcoma cells that lack p53, wild-type p53 decreased, whereas mutated p53 increased IGF-IR expression, and IGF-I-induced tyrosine phosphorylation of the IGF-IR. Similarly, wild-type p53 decreased IGF-I-induced tyrosine phosphorylation of IRS-1. A functional and physical interaction between p53 and Sp1, in the regulation of the IGF-R, was studied in osteosarcoma cells. Expression of p53 decreased IGF-IR promoter activity, whereas no effect on promoter activity was seen by Sp1 expressed alone. However, Sp1 counteracted the inhibitory effect of p53 on IGF-IR promoter activity in a dose-dependent manner. Furthermore, wild-type and mutated p53 were coimmunoprecipitated with Sp1, indicating a physical interaction between p53 and Sp1. In conclusion, p53 regulates IGF-IR expression, as reflected by a reduction in IGF-IR protein and a parallel reduction in IGF-I-induced tyrosine phosphorylation of the IGF-IR and IRS-1 in an osteosarcoma cell line. These data indicate that the IGF-I receptor is a physiological target for p53 in osteosarcoma cells. Furthermore, data supporting an interaction between p53 and Sp1 in the regulation of the promoter activity of IGF-IR are presented.
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6.
  • Werner, Jeff D., 1961- (author)
  • Gudar & giganter.
  • 1995
  • In: Berliner Luft / redaktör och förord: Maj-Brit Wadell. ; , s. 24-40
  • Journal article (peer-reviewed)
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7.
  • Werner, Jeff D., 1961- (author)
  • Nils Nilsson
  • 1997
  • Book (other academic/artistic)
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8.
  • Werner, Jeff D., 1961- (author)
  • Soutines sillar.
  • 1996
  • In: Det skapande jaget. - Göteborg : Konstvetenskapliga inst., Gbgs univ.. ; , s. 11-24
  • Book chapter (other academic/artistic)
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  • Result 1-8 of 8

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