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Träfflista för sökning "WFRF:(Wester R.) srt2:(1995-1999)"

Search: WFRF:(Wester R.) > (1995-1999)

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1.	Danfors, T, et al. (author) Dopaminergic function in autism : Preliminary report of a therapy study with 6-r Tetrahydrobiopterin (THBP) 1999 In: Journal of Child Neurology. - : SAGE Publications. - 0883-0738 .- 1708-8283. ; 14:5, s. 322-322 Review (other academic/artistic)
2.	Nygren, P, et al. (author) Activity of standard and investigational cytotoxic drugs in primarycultures of tumor cells from patients with kidney and urinary bladdercarcinomas. 1999 In: J Urol. ; 162, s. 2200- Journal article (peer-reviewed)
3.	Wester, L, et al. (author) Receptor for alpha1-microglobulin on T lymphocytes : inhibition of antigen-induced interleukin-2 production 1998 In: Scandinavian Journal of Immunology. - : Wiley. - 0300-9475 .- 1365-3083. ; 48:1, s. 1-7 Journal article (peer-reviewed)abstract The human plasma protein alpha1-microglobulin (alpha1m) was found to inhibit the antigen-induced interleukin-2 (IL-2) production of two different mouse T-helper cell hybridomas. Alpha1m isolated from human plasma and recombinant alpha1m isolated from baculovirus-infected insect cell cultures had similar inhibitory effects. Flow cytometric analysis showed a binding of plasma and recombinant alpha1m to the T-cell hybridomas as well as to a human T-cell line. Radiolabelled plasma and recombinant alpha1m bound to the T-cell hybridomas in a saturable manner and the binding could be eliminated by trypsination of the cells. The affinity constants for the cell binding were calculated to be 0.4-1 x 10(5) M(-1) using Scatchard plotting, and the number of binding sites per cell was estimated to be 5 x 10(5)-1 x 10(6). The cell-surface proteins of one of the T-cell hybridomas were radiolabelled, the cells lysed and alpha1m-binding proteins isolated by affinity chromatography. SDS-PAGE and autoradiography analysis of the eluate revealed major bands with Mr-values around 70, 35 and 15 kDa. The results thus suggest that alpha1m binds to a specific receptor on T cells and that the binding leads to inhibition of antigen-stimulated IL-2 production by T-helper cells.

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Type of publication: journal article (2); review (1)

Type of content: peer-reviewed (2); other academic/artistic (1)

Author/Editor: Holmdahl, R (1); Malmstrom, PU (1); Watanabe, Y. (1); Wester, K. (1); von Knorring, Anne-L ... (1); Tedroff, J (1); show more...; Hartvig, P (1); Larsson, R (1); Åkerström, B (1); Långström, B. (1); Moulder, R (1); Eeg-Olofsson, Orvar (1); Strömberg, Bo (1); Wester, L. (1); Nygren, P (1); Busch, C (1); Olofsson, T (1); Michaelsson, E. (1); Csoka, K (1); Danfors, T (1); Torstenson, R (1); Wester, Y (1); show less...

University: Uppsala University (2); Lund University (1)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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