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Träfflista för sökning "WFRF:(Wickelgren Mikael) srt2:(2015-2019)"

Search: WFRF:(Wickelgren Mikael) > (2015-2019)

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1.
  • Andersson, Thomas, 1970-, et al. (author)
  • Building traits for organizational resilience through balancing organizational structures
  • 2019
  • In: Scandinavian Journal of Management. - : Elsevier. - 0956-5221 .- 1873-3387. ; 35:1, s. 36-45
  • Journal article (peer-reviewed)abstract
    • This paper describes and explains how balancing organizational structures can build traits for organizational resilience. Organizational resilience is a holistic and complex concept. In this paper, we move beyond focusing on sudden and disruptive events in favour of anticipating the unexpected in daily organizing. Organizational resilience is understood here as building traits of risk awareness, preference for cooperation, agility and improvisation and is analysed by means of a longitudinal qualitative case study. The paper contributes to the field by showing how balancing organizational structures can foster organizational resilience traits. We show that power distribution and normative control can create preparedness for unexpected events and foster action orientation at the same time as supporting organizational alignment. 
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2.
  • Wickelgren, Mikael, 1962-, et al. (author)
  • How incentive systems arrived in Sweden : a tale of travelling ideas and ghost myths in action
  • 2018
  • In: International Journal of Management Concepts and Philosophy. - : Inderscience Publishers. - 1478-1484 .- 1741-8135. ; 11:1, s. 67-81
  • Journal article (peer-reviewed)abstract
    • This paper describes and explains how and why incentive systems began spreading in Sweden, despite the differences between the dominating business values in the USA (where incentive systems originated) and Sweden. A ghost myth in Sweden’s national business system explains why it happened when it did. Theories on travelling ideas underemphasise the fact that organisations/countries hold varying and competing ideas of suitable practices at the same time. Ghost myths are important alternative concepts which are activated when contextual circumstances arise for a shift in practices. This research is based on a hermeneutic and qualitative approach using texts and interviews and it highlights the role of ghost myths in terms of how ideas travel and how they are translated in different contexts.
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3.
  • Andersson, Thomas, 1970-, et al. (author)
  • Career in Swedish Retail
  • 2016
  • Reports (peer-reviewed)abstract
    • A career in retailing is to a large extent a boundaryless career. A career in retail does not limit the individual to a single organisation, to a single role/position, or to a hierarchical rung on the organisational ladder. Both co-workers and managers move quite easily among organisations within the same retail area, between different retail areas, and in and out of the retail sector.• In the past, the description of retailing as a transitory employment sector has had a negative connotation. Yet this description can also have quite a positive connotation. For example, experience acquired in the retail sector can be very useful in other work sectors. Moreover, people working in retail are generally motivated by job security, a job that is possible to combine to leisure/family, and a job close to home. They are typically much less motivated by traditional career advancement opportunities, the exercise of power over others, and by the desire to make decisions.• People working in retail have a rather limited interest in becoming managers in part because their major work motivators are not the motivators one usually associates with management career paths.• Gender is a relatively weak distinguishing variable in terms of retail careers, but there are some statistically significant – yet small – differences in the work characteristics of men and women in retail. For example, women in retail prioritize work-life balance, the proximity of workplace to home, and outside interests more than men in retail. These priorities have a limiting effect on their opportunities to accept managerial positions and to follow traditional, upward career paths.• There are more women than men working in the retail sector today, but a larger percentage of men in management positions. However, this cannot be explained by differences between the motivations of men and women to become managers or in their attitudes towards their own managerial capabilities. The explanation lies in other, more indirect factors such as the expectations of today’s managers.• Women generally earn less than men in the retail sector. This inequality is especially evident when differences in work responsibilities exist (e.g., specialized areas, subbranches, management tasks).• There is some general scepticism among employees in the retail sector as far as the extent to which their employers are willing to commit to their well-being and development. This finding has important practical implications when employees sense a lack of employer commitment to them.• People outside retail sector generally have a more negative picture of the retail sector than the people within the sector. People in the retail sector are relatively satisfied and think their work is varied and interesting.• The number of women at the lower management levels (at the store-level) is increasing. Because of this trend, which is expected to continue, in the relatively near future there may be as many female managers as male managers at this level. However, at the upper management levels in retail, there are more than ten men for every woman and no indications of change.• Job security is the most important career anchor for retail employees in Sweden. This finding has very important practical implications because job security is typically not associated with employment in the retail sector. It is a factor that can be an important consideration for retailers.
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5.
  • Christophersen, Mikael K., et al. (author)
  • SMIM1 variants rs1175550 and rs143702418 independently modulate Vel blood group antigen expression
  • 2017
  • In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
  • Journal article (peer-reviewed)abstract
    • The Vel blood group antigen is expressed on the red blood cells of most individuals. Recently, we described that homozygosity for inactivating mutations in SMIM1 defines the rare Vel-negative phenotype. Still, Vel-positive individuals show great variability in Vel antigen expression, creating a risk for Vel blood typing errors and transfusion reactions. We fine-mapped the regulatory region located in SMIM1 intron 2 in Swedish blood donors, and observed a strong correlation between expression and rs1175550 as well as with a previously unreported tri-nucleotide insertion (rs143702418; C > CGCA). While the two variants are tightly linked in Caucasians, we separated their effects in African Americans, and found that rs1175550G and to a lesser extent rs143702418C independently increase SMIM1 and Vel antigen expression. Gel shift and luciferase assays indicate that both variants are transcriptionally active, and we identified binding of the transcription factor TAL1 as a potential mediator of the increased expression associated with rs1175550G. Our results provide insight into the regulatory logic of Vel antigen expression, and extend the set of markers for genetic Vel blood group typing.
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6.
  • Linnéusson, Gary, et al. (author)
  • A path forward : Systems thinking maintenance as part of shift in mind on added value
  • 2015
  • Conference paper (peer-reviewed)abstract
    • Abstract: The purpose and novelty with this recently started research is the introduction of a modelling concept that aims to include the interdependencies maintenance have with financial figures, customer behavior, and production, using systems thinking. It suggests on a path forward in acknowledging short- and long term effects from maintenance on the production system and its financial results. Using systems thinking modelling enables learning on consequences from strategies and policies on the studied system; enabling evaluation of future scenarios supporting decision makers in defining sustainable strategies of action on the policy-level. This paper provides a brief outline of the thoughts behind the research project and points the direction for future research by first introducing aspects regarding the problem and possibilities to address, then briefly introduce different modelling approaches that in part address the problem, which is summarized into a path forward, and finally includes an example of a model by the author of a machine strategy problem that connects the physical assets and actions with financial costs.
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7.
  • Linnéusson, Gary, et al. (author)
  • In Need for Better Maintenance Cost Modelling to Support the Partnership with Manufacturing
  • 2016. - 1
  • In: Current Trends in Reliability, Availability, Maintainability and Safety. - Cham : Springer. - 9783319235967 - 9783319235974 ; , s. 263-282
  • Conference paper (other academic/artistic)abstract
    • The problem of maintenance consequential costs has to be dealt with in manufacturing and is core of this paper. The need of sustainable partnership between manufacturing and maintenance is addressed. Stuck in a best practice thinking, applying negotiation as a method based on power statements in the service level agreement, the common best possible achievable goal is put on risk. Instead, it may enforce narrow minded sub optimized thinking even though not intended so. Unfortunately, the state of origin is not straightforward business. Present maintenance cost modelling is approached, however limits to its ability to address the dynamic complexity of production flows are acknowledged. The practical problem to deal with is units put together in production flows; in which downtime in any unit may or may not result in decreased throughput depending on its set up. In this environment accounting consequential costs is a conundrum and a way forward is suggested. One major aspect in the matter is the inevitable need of shift in mind, from perspective thinking in maintenance and manufacturing respectively towards shared perspectives, nourishing an advantageous sustainable partnership.
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8.
  • Lundqvist, Annika, 1969, et al. (author)
  • The Arachidonate 15-Lipoxygenase Enzyme Product 15-HETE Is Present in Heart Tissue from Patients with Ischemic Heart Disease and Enhances Clot Formation
  • 2016
  • In: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 11:8
  • Journal article (peer-reviewed)abstract
    • Ischemic heart disease is a major cause of death and morbidity and the search for novel therapeutic targets is still required. We have previously shown that the enzyme arachidonate 15 lipoxygenase (ALOX15), which catalyzes the conversion of arachidonic acid to 15-hydroxy eicosatetraenoic acid (15-HETE), is highly expressed in ischemic heart tissue, but its role in the pathogenesis of ischemic heart disease is unclear. Here we showed that expression of ALOX15, but not ALOX12 or ALOX15B, was increased in ischemic versus non-ischemic human heart biopsy samples. A similar ALOX expression pattern was found in hypoxic human cardiomyocytes and cardiac endothelial cells. We also showed that levels of 15-HETE were significantly higher in ischemic versus non-ischemic human heart biopsy samples and showed a tendency to increase in serum from the patients with ischemic heart disease. Moreover, hypoxia increased the production of 15-HETE levels from human cardiomyocytes and cardiac endothelial cells. The hypoxia-induced increase in 15-HETE levels from human cardiomyocytes was inhibited by the ALOX15 inhibitor baicalein. Finally, by using intrinsic rotational thromboelastometry, we showed that human whole blood clotted faster in the presence of 15-HETE. In summary, we propose that increased ALOX15 expression in heart tissue under ischemic conditions may lead to increased production of 15-HETE, potentially contributing to thrombosis.
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  • Result 1-8 of 8

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