| 1. |
- Thomas, HS, et al.
(author)
-
- 2019
-
swepub:Mat__t
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Novikova, P. Y., et al.
(author)
-
Sequencing of the genus Arabidopsis identifies a complex history of nonbifurcating speciation and abundant trans-specific polymorphism
- 2016
-
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 48:9, s. 1077-1082
-
Journal article (peer-reviewed)abstract
- The notion of species as reproductively isolated units related through a bifurcating tree implies that gene trees should generally agree with the species tree and that sister taxa should not share polymorphisms unless they diverged recently and should be equally closely related to outgroups. It is now possible to evaluate this model systematically. We sequenced multiple individuals from 27 described taxa representing the entire Arabidopsis genus. Cluster analysis identified seven groups, corresponding to described species that capture the structure of the genus. However, at the level of gene trees, only the separation of Arabidopsis thaliana from the remaining species was universally supported, and, overall, the amount of shared polymorphism demonstrated that reproductive isolation was considerably more recent than the estimated divergence times. We uncovered multiple cases of past gene flow that contradict a bifurcating species tree. Finally, we showed that the pattern of divergence differs between gene ontologies, suggesting a role for selection. © 2016 Nature America, Inc. All rights reserved.
|
|
| 5. |
- Tercero, M., et al.
(author)
-
5G systems: The mmMAGIC project perspective on use cases and challenges between 6-100 GHz
- 2016
-
In: IEEE Wireless Communications and Networking Conference, WCNC. - 1525-3511. ; 2016-September, s. 200-205
-
Conference paper (peer-reviewed)abstract
- mmMAGIC (Millimetre-Wave Based Mobile Radio Access Network for Fifth Generation Integrated Communications) is an EU funded 5G-PPP project, whose overall objective is to design and pre-develop a mobile radio access technology (RAT) operating in the 6-100 GHz range, capable of impacting standards and other relevant fora. The focus of the project is on extreme Mobile Broadband, which is expected to drive the 5G requirements for massive increase in capacity and data-rates. This paper elaborates on some 5G key research areas such as: identification of the most compelling use-cases and Key Performance Indicators (KPIs) for future 5G systems, advantages and challenges of millimeter-wave (mmWave) technologies, channel measurements and channel modeling, network architecture; and the design of a new mobile radio interface including multi-node and multi-Antenna transceiver architecture.
|
|
| 6. |
- Tschudin-Sutter, S., et al.
(author)
-
Guidance document for prevention of Clostridium difficile infection in acute healthcare settings
- 2018
-
In: Clinical Microbiology and Infection. - : Blackwell Publishing. - 1198-743X .- 1469-0691. ; 24:10, s. 1051-1054
-
Research review (peer-reviewed)abstract
- SCOPE: Clostridium difficile infection (CDI) is the most important infective cause of healthcare-associated diarrhoea in high income countries and one of the most important healthcare-associated pathogens in both Europe and the United States. It is associated with high morbidity and mortality resulting in both societal and financial burden. A significant proportion of this burden is potentially preventable by a combination of targeted infection prevention and control measures and antimicrobial stewardship. The aim of this guidance document is to provide an update on recommendations for prevention of CDI in acute care settings to provide guidance to those responsible for institutional infection prevention and control programmes.METHODS: An expert group was set up by the European society of clinical microbiology and infectious diseases (ESCMID) Study Group for C. difficile (ESGCD), which performed a systematic review of the literature on prevention of CDI in adults hospitalized in acute care settings and derived respective recommendations according to the GRADE approach. Recommendations are stratified for both outbreak and endemic settings.QUESTIONS ADDRESSED BY THE GUIDELINE AND RECOMMENDATIONS: This guidance document provides thirty-six statements on strategies to prevent CDI in acute care settings, including 18 strong recommendations. No recommendation was provided for three questions.
|
|
| 7. |
- Bahaloo, Hassan, 1983-, et al.
(author)
-
On the failure initiation in the proximal human femur under simulated sideways fall
- 2018
-
In: Annals of Biomedical Engineering. - : Springer. - 0090-6964 .- 1573-9686. ; 46, s. 270-283
-
Journal article (peer-reviewed)abstract
- The limitations of areal bone mineral density measurements for identifying at-risk individuals have led to the development of alternative screening methods for hip fracture risk including the use of geometrical measurements from the proximal femur and subject specific finite element analysis (FEA) for predicting femoral strength, based on quantitative CT data (qCT). However, these methods need more development to gain widespread clinical applications. This study had three aims: To investigate whether proximal femur geometrical parameters correlate with obtained femur peak force during the impact testing; to examine whether or not failure of the proximal femur initiates in the cancellous (trabecular) bone; and finally, to examine whether or not surface fracture initiates in the places where holes perforate the cortex of the proximal femur. We found that cortical thickness around the trochanteric-fossa is significantly correlated to the peak force obtained from simulated sideways falling (R 2 = 0.69) more so than femoral neck cortical thickness (R 2 = 0.15). Dynamic macro level FE simulations predicted that fracture generally initiates in the cancellous bone compartments. Moreover, our micro level FEA results indicated that surface holes may be involved in primary failure events.
|
|
| 8. |
|
|
| 9. |
- Fresia, Maria, et al.
(author)
-
Use case characterization, KPIs and preferred suitable frequency ranges for future 5G systems between 6 GHz and 100 GHz
- 2015
-
Reports (other academic/artistic)abstract
- In this deliverable use cases and KPIs of interest for mmMAGIC are characterized. Eight usecases suitable for 5G systems operating in the range 6-100GHz are identified in terms ofrequirements. In particular, the following use cases are analyzed: Media on demand; Cloudservices; Dense urban society with distributed crowds; Smart offices; Immersive 5G earlyexperience in targeting hot spots; 50+Mbps everywhere; Moving hot spots; Tactileinternet/video augmented robotic control and remote-robot manipulation surgery. For each ofthe use cases, the more critical KPIs are identified and the gap from the current technologyis also described.An analysis of frequency ranges for future 5G systems between 6 GHz and 100 GHz is reported. A frequency assessment study is conducted in order to compare the frequency ranges for the suitability of delivering key KPIs.
|
|
| 10. |
- Luo, Y., et al.
(author)
-
The roles of genetic drift and natural selection in quantitative trait divergence along an altitudinal gradient in Arabidopsis thaliana
- 2015
-
In: Heredity. - : Springer Science and Business Media LLC. - 0018-067X .- 1365-2540. ; 114:2, s. 220-228
-
Journal article (peer-reviewed)abstract
- Understanding how natural selection and genetic drift shape biological variation is a central topic in biology, yet our understanding of the agents of natural selection and their target traits is limited. We investigated to what extent selection along an altitudinal gradient or genetic drift contributed to variation in ecologically relevant traits in Arabidopsis thaliana. We collected seeds from 8 to 14 individuals from each of 14 A. thaliana populations originating from sites between 800 and 2700 m above sea level in the Swiss Alps. Seed families were grown with and without vernalization, corresponding to winter-annual and summer-annual life histories, respectively. We analyzed putatively neutral genetic divergence between these populations using 24 simple sequence repeat markers. We measured seven traits related to growth, phenology and leaf morphology that are rarely reported in A. thaliana and performed analyses of altitudinal clines, as well as overall Q(ST)-F-ST comparisons and correlation analyses among pair-wise Q(ST), F-ST and altitude of origin differences. Multivariate analyses suggested adaptive differentiation along altitude in the entire suite of traits, particularly when expressed in the summer-annual life history. Of the individual traits, a decrease in rosette leaf number in the vegetative state and an increase in leaf succulence with increasing altitude could be attributed to adaptive divergence. Interestingly, these patterns relate well to common within- and between-species trends of smaller plant size and thicker leaves at high altitude. Our results thus offer exciting possibilities to unravel the underlying mechanisms for these conspicuous trends using the model species A. thaliana.
|
|
