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- Csernok, E, et al.
(author)
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Evaluation of capture ELISA for detection of antineutrophil cytoplasmic antibodies directed against proteinase 3 in Wegener's granulomatosis: first results from a multicentre study
- 2004
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In: Rheumatology. - : Oxford University Press (OUP). - 1462-0332 .- 1460-2172. ; 43:2, s. 174-180
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Journal article (peer-reviewed)abstract
- Objective: To evaluate the performance characteristics of direct and capture ELISA for the detection of PR3-ANCA in Wegener's granulomatosis (WG) in international ANCA reference laboratories. Methods: Serum samples were derived from patients with histological and clinical diagnosis of WG (n = 60), rheumatoid arthritis (RA) (n = 30) and healthy controls (n = 30). Each of them was tested for the presence of ANCA by indirect immunofluorescence technique (IFT), direct and capture ELISA in six international reference laboratories (Massachusetts General Hospital, Boston; Wieslab AB, Lund; University of Maastricht; University Hospital Groningen; Mayo Clinic, Rochester; Rheumaklinik Bad Bramstedt/University of Schleswig-Holstein Campus Lubeck). Each centre tested the sera according to their house protocols of IFT and ELISA. The diagnostic performance of each test was estimated by receiver operating characteristic curve analysis and sensitivity and specificity in detection of ANCA/PR3-ANCA were calculated for the respective methods. Results: In patients histologically and clinically known as WG, the detection of ANCA by IFT varied between 52 and 83% among the participating centres. PR3-ANCA positivity with the different ELISAs ranged from 53 to 80% in direct ELISA and from 72 to 76% in capture ELISA. While most capture ELISAs successfully detected PR3-ANCA, there were significant differences between IFT and direct ELISA results between laboratories. ROC curve analysis demonstrated that in five of six laboratories the overall diagnostic performance of capture ELISA was superior to IFT and direct ELISA, respectively. Conclusion: Capture ELISA is a highly sensitive assay for detection of PR3-ANCA in WG and should be used in conjunction with compatible clinical picture and histological evidence.
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| 2. |
- Roorda, Jan-Willem, 1975, et al.
(author)
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Iterated Belief Change in Multi Agent Systems
- 2003
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In: Logic Journal of the IGPL. - : Oxford University Press (OUP). - 1367-0751 .- 1368-9894. ; 11:2, s. 223-246
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Journal article (peer-reviewed)abstract
- We give a model for iterated belief change in multi-agent systems. The formal tool we use for this is a combination of modal and dynamic logic. Two core notions in our model are the expansion of the knowledge and beliefs of an agent, and the processing of new information. An expansion is defined as the change in the knowledge and beliefs of an agent when it decides to believe an incoming formula while holding on to its current propositional beliefs. To prevent our agents from forming inconsistent beliefs they do not expand with every piece of information they receive. Instead, our agents remember their original beliefs and every piece of information they receive. After every receipt of information they decide which (consistent) subset of the received information should be incorporated into their original beliefs. This procedure is called the processing of new information. We show that our model of belief update behaves in an intuitive way and that it is not sensitive to criticism on comparable models.
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| 3. |
- Roorda, Jan-Willem, 1975, et al.
(author)
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Iterated belief change in multi-agent systems
- 2002
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In: Proceedings of the 1st International Joint Conference on: Autonomous Agents adn Multiagent Systems, Bologna, 15-19 July 2002. - New York, New York, USA : ACM Press. - 1581134800 ; , s. 889-896
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Conference paper (peer-reviewed)abstract
- We give a model for iterated belief change in multi-agent systems. The formal tool we use for this is a combination of modal and dynamic logic. Two core notions in our model are the expansion of the knowledge and beliefs of an agent, and the processing of new information. An expansion has been defined as the change in the knowledge and beliefs of an agent when it decides to believe an incoming formula while holding on to its current propositional beliefs. To prevent our agents from forming inconsistent beliefs they do not expand with every piece of information they receive. Instead, our agents remember their original beliefs and every piece of information they receive. After every receipt of information they decide which (consistent) subset of the received information should be incorporated into their original beliefs. This procedure is called the processing of new information. We show that our model of belief update behaves in an intuitive way and that it is not sensitive to criticism on comparable models.
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