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Träfflista för sökning "WFRF:(Willems Patrick) srt2:(2018)"

Search: WFRF:(Willems Patrick) > (2018)

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1.
  • Amaya, Andres Gonzales, et al. (author)
  • Assessment of rainfall variability and its relationship to ENSO in a sub-Andean watershed in central Bolivia
  • 2018
  • In: Water. - : MDPI AG. - 2073-4441. ; 10:6
  • Journal article (peer-reviewed)abstract
    • Climate change and variability are likely to increase in most parts of the world, leading to more extreme events, which may increase the stress on already threatened water resources. This study focuses on the effects of the El Niño Southern Oscillation in the rainfall of Pucara basin and in the groundwater levels of the Punata alluvial fan in the Bolivian sub-Andes. Climate change and variability were assessed using the Quantile Perturbation Method, by detecting anomalous temporal changes in extreme quantiles of annual precipitation in the Pucara watershed and the correlation with groundwater levels in the Punata fan. The results show oscillatory behavior over periods of 28 to 33 years for the occurrence of wet and dry extremes at all studied meteorological stations. This suggests a similar oscillatory behavior of the groundwater levels; however, longer groundwater level observations are needed in order to confirm the link between precipitation variability and groundwater fluctuations. Local actors such as water managers, farmers and decision makers must take into consideration this climate variability in order to plan for these multi-decadal variations in response to the changes.
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2.
  • Turcot, Valerie, et al. (author)
  • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
  • 2018
  • In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 50:1, s. 26-41
  • Journal article (peer-reviewed)abstract
    • Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. The effect sizes of rare variants are similar to 10 times larger than those of common variants, with the largest effect observed in carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed similar to 7 kg more than non-carriers. Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
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