| 1. |
|
|
| 2. |
- Newton-Cheh, Christopher, et al.
(author)
-
Genome-wide association study identifies eight loci associated with blood pressure
- 2009
-
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:6, s. 666-676
-
Journal article (peer-reviewed)abstract
- Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N <= 71,225 European ancestry, N <= 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 x 10(-24)), CYP1A2 (P = 1 x 10(-23)), FGF5 (P = 1 x 10(-21)), SH2B3 (P = 3 x 10(-18)), MTHFR (P = 2 x 10(-13)), c10orf107 (P = 1 x 10(-9)), ZNF652 (P = 5 x 10(-9)) and PLCD3 (P = 1 x 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.
|
|
| 3. |
- Crossley, I. R., et al.
(author)
-
Synthesis of the ruthenaboratranes Ru(CS)(PPh3){B(mt)(3)} (Ru -> B)(8) and Ru(CO)(CNR){B(mt)(3)} (Ru -> B)(8) (mt = methimazolyl, R = Bu-t, C6H3Me2-2,6, C6H2Me3-2,4,6)
- 2008
-
In: Organometallics. - : American Chemical Society (ACS). - 0276-7333 .- 1520-6041. ; 27:3, s. 381-386
-
Journal article (peer-reviewed)abstract
- The reaction of [Ru(CH=CH2)Cl(CS)(PPh3)(2)] with Na[HB(mt)(3)] (mt = methimazolyl) provides the ruthenaboratrane [Ru(CS)(PPh3){B(mt)(3)}]. The reaction of [Ru(CO)(PPh3){B(mt)3}] with CO to provide [Ru(CO)(2){B(mt)(3)}] is reversible, while the phosphine-free ruthenaboratranes [Ru(CO)(CNR){B(mt(3))}] (R = Bu-t, C6H3Me2-2,6, C6H2Me3-2,4,6) form irreversibly upon addition of isonitriles (CNR) to [Ru(CO)(PPh3){B(mt)(3)}]. The crystal structures of the ruthenaboratranes [Ru(CS)(PPh3){B(mt)(3)}], [Ru(CO)((CNBu)-Bu-t)({B(mt)(3)}], and [Ru(CO)(CNC6H2Me3-2,4,6){B(mt)(3)}] are reported.
|
|
| 4. |
- Crossley, I. R., et al.
(author)
-
The first rhodaboratrane: RhCl(PPh3){B(mt)(3)} (Rh -> B) (mt = methimazolyl)
- 2005
-
In: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1364-548X .- 1359-7345. ; :2, s. 221-223
-
Journal article (peer-reviewed)abstract
- The reaction of [Rh(C6H5)Cl-2(PPh3)(2)] with Na[HB(mt)(3)] (mt = methimazolyl) provides [RhCl(PPh3){B(mt)(3)}](Rh-->B) the first authentic example of a compound with a rhodium boron dative bond.
|
|
| 5. |
- Brose, Ulrich, et al.
(author)
-
Body sizes of consumers and their resources
- 2005
-
In: Ecology. - : Ecological Society of America. - 0012-9658 .- 1939-9170. ; 86:9, s. 2545-2545
-
Journal article (peer-reviewed)abstract
- Trophic information—who eats whom—and species’ body sizes are two of the most basic descriptions necessary to understand community structure as well as ecological and evolutionary dynamics. Consumer–resource body size ratios between predators and their prey, and parasitoids and their hosts, have recently gained increasing attention due to their important implications for species’ interaction strengths and dynamical population stability. This data set documents body sizes of consumers and their resources. We gathered body size data for the food webs of Skipwith Pond, a parasitoid community of grass-feeding chalcid wasps in British grasslands; the pelagic community of the Benguela system, a source web based on broom in the United Kingdom; Broadstone Stream, UK; the Grand Caric¸aie marsh at Lake Neuchaˆtel, Switzerland; Tuesday Lake, USA; alpine lakes in the Sierra Nevada of California; Mill Stream, UK; and the eastern Weddell Sea Shelf, Antarctica. Further consumer–resource body size data are included for planktonic predators, predatory nematodes, parasitoids, marine fish predators, freshwater invertebrates, Australian terrestrial consumers, and aphid parasitoids. Containing 16 807 records, this is the largest data set ever compiled for body sizes of consumers and their resources. In addition to body sizes, the data set includes information on consumer and resource taxonomy, the geographic location of the study, the habitat studied, the type of the feeding interaction (e.g., predacious, parasitic) and the metabolic categories of the species (e.g., invertebrate, ectotherm vertebrate). The present data set was gathered with the intent to stimulate research on effects of consumer–resource body size patterns on food-web structure, interaction-strength distributions, population dynamics, and community stability. The use of a common data set may facilitate cross-study comparisons and understanding of the relationships between different scientific approaches and models.
|
|
| 6. |
- Holmes, Emily A., et al.
(author)
-
Imagery about suicide in depression - "Flash-forwards"?
- 2007
-
In: Journal of Behavior Therapy and Experimental Psychiatry. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0005-7916 .- 1873-7943. ; 38:4, s. 423-434
-
Journal article (peer-reviewed)abstract
- Suicide is a significant world health problem, with more deaths by suicide globally than by war. We need to better understand the cognitive processes underlying suicidal thinking for improved treatment development. Cognitive psychology indicates that mental imagery can be causal in determining future behavior, yet the occurrence of suicide-related imagery has not previously been investigated. Interviews with 15 depressed and formerly suicidal patients in remission found that all patients reported experiencing detailed mental imagery in addition to verbal thoughts when at their most despairing, for example images of making a future suicide attempt. A clinical measure of the severity of suicidal ideation was associated with both preoccupation with suicide-related imagery and perceived imagery realness. Echoing flashbacks in posttraumatic stress disorder, the current images appeared like "flash-forwards" to suicide. These results provide the first data to our knowledge on the existence of mental imagery in suicidality, opening a promising new avenue for research. (C) 2007 Elsevier Ltd. All rights reserved.
|
|
| 7. |
- Olsson, CJ, 1980-
(author)
-
Imaging imagining actions
- 2008
-
Doctoral thesis (other academic/artistic)abstract
- Mental training has been studied extensively for the past century but we are still not completely sure how it affects brain and behavior. The aim of this doctoral thesis was to examine one aspect of mental training i.e. motor imagery. In Study I, active high jumpers were trained for 6 weeks using a motor imagery mental training program. We measured behavioral effects in motor parameters such as total height, false attempts, take off angle, and bar clearance. A significant improvement was found on the bar clearance component compared to a control group of high jumpers that did not participate in the mental training program. The results emphasize the importance of using appropriate outcome measures since mental training may affect distinct features of the movement rather than the entire movement. Study II used fMRI (functional Magnetic Resonance Imaging) to examine the neural correlates of imagery for active high jumpers, and also how imagery training affects brain activity. Active high jumpers were compared to a control group of high jumping novices and the results showed that high jumpers were able to activate motor regions, whereas controls used parts of the visual system to perform imagery of the high jump. Thus, we were able to show how important well established motor representations are in order to achieve a neural overlap between imagery and action. In study III we examined the effects after motor, mental and combined motor and mental training on a finger tapping task. Behaviorally, even though mental training improved performance, adding mental training to motor training did not improve the results beyond only using motor training. Imaging results showed that motor and mental training engaged different neural systems, with motor training associated with motor activity and mental training with visual activity. The combination of motor and mental training activated both motor and visual systems. Additionally combining motor and mental training resulted in transfer to an untrained motor sequence and neural data indicated that cerebellum mediated the transfer. The overall findings explain how mental training can be used to improve motor performance and motor parameters. Moreover, it also illustrates that the neural processes underlying such improvements may be distinct from motor training and that the brain may react differently during mental training depending on prior physical experience of the action.
|
|
