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Träfflista för sökning "WFRF:(Ye Yu) srt2:(2000-2004)"

Search: WFRF:(Ye Yu) > (2000-2004)

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  • Ye, L., et al. (author)
  • Towards the development of molecularly imprinted artificial receptors for the screening of estrogenic chemicals
  • 2001
  • In: Analyst. - : Royal Society of Chemistry (RSC). - 0003-2654. ; 126:6, s. 760-765
  • Journal article (peer-reviewed)abstract
    • Molecularly imprinted polymers are prepared using various steroid compounds as the templates. The imprinted polymers can selectively re-bind the original print molecules, which leads to versatile potential applications. The feasibility of using these artificial receptors to replace their biological counterparts for preliminary screening of a chemical library is demonstrated. A steroid library composed of 22 closely related compounds is screened with an estrogen specific polymer. The print molecule is identified with accuracy and structural similarities of other members are correlated with normalized retention indices. Molecularly imprinted artificial receptors are envisioned as being useful for screening purposes in drug discovery or for identifying endocrine-disrupting chemicals.
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  • Yu, Yihua, et al. (author)
  • Removal of the fermentation by-product succinyl L-tyrosine from the beta-lactamase inhibitor clavulanic acid using a molecularly imprinted polymer
  • 2002
  • In: Biotechnology and Bioengineering. - : Wiley. - 1097-0290 .- 0006-3592. ; 79:1, s. 23-28
  • Journal article (peer-reviewed)abstract
    • Clavulanic acid is a beta-lactamase inhibitor used in therapeutic combinations with the penicillin-type antibiotics. During the fermentation leading to clavulanic acid, a succinyl L-tyrosine by-product is unavoidably formed. Occasionally, the amount of this by-product is found to be as high as 2% of the product even after standard purification operations. To further remove this impurity, we prepared a highly specific adsorbent for succinyl L-tyrosine with the molecular imprinting technique. This was performed by simultaneously using vinylbenzyl trimethylammonium chloride and methacrylic acid as the functional monomers. The imprinted polymer selectively bound succinyl L-tyrosine, and could be successfully used to remove this impurity at concentrations of less than 2% in the presence of clavulanic acid.
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  • Result 1-6 of 6

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