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Träfflista för sökning "WFRF:(Yeganeh B.) srt2:(2005-2009)"

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1.	Woellner, C, et al. (author) Diagnostic criteria for the hyper IgE recurrent infection syndrome/Job's syndrome/STAT3 deficiency 2008 In: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. - 0009-9104. ; 154, s. 154-155 Conference paper (other academic/artistic)
2.	Ghavami, S., et al. (author) Apoptosis and cancer : mutations within caspase genes 2009 In: Journal of Medical Genetics. - : B M J Group. - 0022-2593 .- 1468-6244. ; 46:8, s. 497-510 Research review (peer-reviewed)abstract The inactivation of programmed cell death has profound effects not only on the development but also on the overall integrity of multicellular organisms. Beside developmental abnormalities, it may lead to tumorigenesis, autoimmunity, and other serious health problems. Deregulated apoptosis may also be the leading cause of cancer therapy chemoresistance. Caspase family of cysteinyl-proteases plays the key role in the initiation and execution of programmed cell death. This review gives an overview of the role of caspases, their natural modulators like IAPs, FLIPs, and Smac/Diablo in apoptosis and upon inactivation, and also in cancer development. Besides describing the basic mechanisms governing programmed cell death, a large part of this review is dedicated to previous studies that were focused on screening tumours for mutations within caspase genes as well as their regulators. The last part of this review discusses several emerging treatments that involve modulation of caspases and their regulators. Thus, we also highlight caspase cascade modulating experimental anticancer drugs like cFLIP-antagonist CDDO-Me; cIAP1 antagonists OSU-03012 and ME-BS; and XIAP small molecule antagonists 1396-11, 1396-12, 1396-28, triptolide, AEG35156, survivin/Hsp90 antagonist shephedrin, and some of the direct activators of procaspase-3.

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Type of publication: conference paper (1); research review (1)

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Hammarstrom, L (1); Matamoros, N (1); Marodi, L (1); Plebani, A (1); Khan, S (1); Yeganeh, M (1); show more...; Espanol, T (1); Xiao, W (1); Franco, JL (1); Puck, JM (1); Ande, S.R. (1); Yeganeh, B. (1); Hashemi, M. (1); Ghavami, S. (1); Niehues, T (1); Pignata, C (1); Moilanen, JS (1); Gennery, AR (1); Kilic, SS (1); Bacchetta, R (1); Sanchez, B. (1); Holland, SM (1); Baumann, U (1); Wiechec, Emilia (1); Ehl, S (1); Grimbacher, B (1); Cancrini, C (1); BREBOROWICZ, A (1); Litzman, J. (1); Garty, BZ (1); Los, Marek (1); Abinun, M (1); Davies, EG (1); Junker, A (1); Eshraghi, M. (1); Bus, C. J. (1); Kadkhoda, K. (1); Halayko, A. J. (1); Gertz, EM (1); Arkwright, PD (1); Eren, E. (1); Sanal, O (1); Cossu, F. (1); Hsu, A (1); Woellner, C (1); Schaeffer, AA (1); Lagos, M (1); Perro, M (1); Pietrogrande, MC (1); Pietrucha, B (1); show less...

University: Linköping University (1); Karolinska Institutet (1)

Language: English (2)

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