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- He, Li, et al.
(author)
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An interpretable prediction model of illegal running into the opposite lane on curve sections of two-lane rural roads from drivers’ visual perceptions
- 2023
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In: Accident Analysis and Prevention. - 0001-4575. ; 186
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Journal article (peer-reviewed)abstract
- Illegal running into the opposite lane (IROL) on curve sections of two-lane rural roads is a frequently hazardous behavior and highly prone to fatal crashes. Although driving behaviors are always determined by the information from drivers’ visual perceptions, current studies do not consider visual perceptions in predicting the occurrence of IROL. In addition, most machine learning methods belong to black-box algorithms and lack the interpretation of prediction results. Therefore, this study aims to propose an interpretable prediction model of IROL on curve sections of two-lane rural roads from drivers’ visual perceptions. A new visual road environment model, consisting of five different visual layers, was established to better quantify drivers’ visual perceptions by using deep neural networks. In this study, naturalistic driving data was collected on curve sections of typical two-lane rural roads in Tibet, China. There were 25 input variables extracted from the visual road environment, vehicle kinematics, and driver characteristics. Then, XGBoost (eXtreme Gradient Boosting) and SHAP (SHapley Additive exPlanation) methods were combined to build a prediction model. The results showed that our prediction model performed well, with an accuracy of 86.2% and an AUC value of 0.921. The average lead time of this prediction model was 4.4 s, sufficient for drivers to respond. Due to the advantages of SHAP, this study interpreted the impacting factors on this illegal behavior from three aspects, including relative importance, specific impacts, and variable dependency. After offering more quantitative information on the visual road environment, the findings of this study could improve the current prediction model and optimize road environment design, thereby reducing IROL on curve sections of two-lane rural roads.
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| 2. |
- Lensink, Marc F., et al.
(author)
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Impact of AlphaFold on structure prediction of protein complexes: The CASP15-CAPRI experiment
- 2023
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In: Proteins. - : WILEY. - 0887-3585 .- 1097-0134.
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Journal article (peer-reviewed)abstract
- We present the results for CAPRI Round 54, the 5th joint CASP-CAPRI protein assembly prediction challenge. The Round offered 37 targets, including 14 homodimers, 3 homo-trimers, 13 heterodimers including 3 antibody-antigen complexes, and 7 large assemblies. On average similar to 70 CASP and CAPRI predictor groups, including more than 20 automatics servers, submitted models for each target. A total of 21 941 models submitted by these groups and by 15 CAPRI scorer groups were evaluated using the CAPRI model quality measures and the DockQ score consolidating these measures. The prediction performance was quantified by a weighted score based on the number of models of acceptable quality or higher submitted by each group among their five best models. Results show substantial progress achieved across a significant fraction of the 60+ participating groups. High-quality models were produced for about 40% of the targets compared to 8% two years earlier. This remarkable improvement is due to the wide use of the AlphaFold2 and AlphaFold2-Multimer software and the confidence metrics they provide. Notably, expanded sampling of candidate solutions by manipulating these deep learning inference engines, enriching multiple sequence alignments, or integration of advanced modeling tools, enabled top performing groups to exceed the performance of a standard AlphaFold2-Multimer version used as a yard stick. This notwithstanding, performance remained poor for complexes with antibodies and nanobodies, where evolutionary relationships between the binding partners are lacking, and for complexes featuring conformational flexibility, clearly indicating that the prediction of protein complexes remains a challenging problem.
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