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Träfflista för sökning "WFRF:(Yu Lei) srt2:(2000-2004)"

Search: WFRF:(Yu Lei) > (2000-2004)

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  • Yu, Yihua, et al. (author)
  • Removal of the fermentation by-product succinyl L-tyrosine from the beta-lactamase inhibitor clavulanic acid using a molecularly imprinted polymer
  • 2002
  • In: Biotechnology and Bioengineering. - : Wiley. - 1097-0290 .- 0006-3592. ; 79:1, s. 23-28
  • Journal article (peer-reviewed)abstract
    • Clavulanic acid is a beta-lactamase inhibitor used in therapeutic combinations with the penicillin-type antibiotics. During the fermentation leading to clavulanic acid, a succinyl L-tyrosine by-product is unavoidably formed. Occasionally, the amount of this by-product is found to be as high as 2% of the product even after standard purification operations. To further remove this impurity, we prepared a highly specific adsorbent for succinyl L-tyrosine with the molecular imprinting technique. This was performed by simultaneously using vinylbenzyl trimethylammonium chloride and methacrylic acid as the functional monomers. The imprinted polymer selectively bound succinyl L-tyrosine, and could be successfully used to remove this impurity at concentrations of less than 2% in the presence of clavulanic acid.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Mosbach, Klaus (2)
Ye, Lei (2)
Yu, Yihua (2)
Haupt, Karsten Olaf (1)
de Biasi, V (1)
University
Lund University (2)
Language
English (2)
Research subject (UKÄ/SCB)
Natural sciences (2)
Year
2002 (2)

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