SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Zinzalla G) srt2:(2021)"

Search: WFRF:(Zinzalla G) > (2021)

  • Result 1-2 of 2
Sort/group result
   
EnumerationReferenceCoverFind
1.
  • Allen, MD, et al. (author)
  • SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site
  • 2021
  • In: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 4:1, s. 528-
  • Journal article (peer-reviewed)abstract
    • SWI/SNF (BAF) chromatin remodelling complexes are key regulators of gene expression programs, and attractive drug targets for cancer therapies. Here we show that the N-terminus of the BAF155/SMARCC1 subunit contains a putative DNA-binding MarR-like domain, a chromodomain and a BRCT domain that are interconnected to each other to form a distinct module. In this structure the chromodomain makes interdomain interactions and has lost its canonical function to bind to methylated lysines. The structure provides new insights into the missense mutations that target this module in cancer. This study also reveals two adjacent, highly-conserved pockets in a cleft between the domains that form a potential binding site, which can be targeted with small molecules, offering a new strategy to target SWI/SNF complexes.
  •  
2.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Zinzalla, G (2)
Allen, MD (1)
Bycroft, M (1)
Freund, SMV (1)
University
Karolinska Institutet (2)
Language
English (2)
Year
2021 (2)Undo refine

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view