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Search: WFRF:(van Dijk Ingrid K.) > (2015-2019)

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  • Kilpeläinen, Tuomas O, et al. (author)
  • Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
  • 2016
  • In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
  • Journal article (peer-reviewed)abstract
    • Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P<10(-6) in 19,979 additional individuals. We identify five loci robustly associated (P<5 × 10(-8)) with leptin levels in/near LEP, SLC32A1, GCKR, CCNL1 and FTO. Although the association of the FTO obesity locus with leptin levels is abolished by adjustment for BMI, associations of the four other loci are independent of adiposity. The GCKR locus was found associated with multiple metabolic traits in previous GWAS and the CCNL1 locus with birth weight. Knockdown experiments in mouse adipose tissue explants show convincing evidence for adipogenin, a regulator of adipocyte differentiation, as the novel causal gene in the SLC32A1 locus influencing leptin levels. Our findings provide novel insights into the regulation of leptin production by adipose tissue and open new avenues for examining the influence of variation in leptin levels on adiposity and metabolic health.
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3.
  • Willfuhr, Kai P., et al. (author)
  • Another helping - A plea for studying kin effects from an interdisciplinary perspective
  • 2019
  • In: Historicka Demografie. - 0323-0937. ; 43:2, s. 157-181
  • Journal article (peer-reviewed)abstract
    • Having kin and living together with kin influence the individual life course, including a person’s marriage, reproductive career, and survival. A wide range of mechanisms are involved in connecting these life course transitions to support and competition between kin, as well as to characteristics of the family environment. How kin affect the life course is perceived differently in evolutionary anthropology than in the social sciences, and these perspectives are seldom integrated into research. In the present article, we review predictions of the influence of in-law relatives on fertility and mortality presented in selected studies. We will then discuss their explanatory power by discussing the influence of the mother-in-law on the mortality of reproductive females in the historical populations of the Krummhörn region in Germany (1720-1874) and the St. Lawrence Valley in Quebec, Canada (1670-1799). Social science studies tend to emphasize the role of kin in economic and social resource availability, and especially the family characteristics that are relevant in providing, accessing, and dividing resources. In contrast, evolutionary anthropology tends to emphasize the evolved inclinations of kin to support as well as to compete with each other. On the one hand, we argue that the social sciences would benefit from integrating the evolutionary theory of human behavior. On the other hand, evolutionary anthropology would benefit from the comprehensive acknowledgment of the socio-environmental factors in population since these may mask evolved inclinations.
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