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Träfflista för sökning "hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin) hsv:(Dermatologi och venereologi) srt2:(2005-2009)"

Search: hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Klinisk medicin) hsv:(Dermatologi och venereologi) > (2005-2009)

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  • Nordahl, Emma, et al. (author)
  • Domain 5 of high molecular weight kininogen is antibacterial.
  • 2005
  • In: Journal of Biological Chemistry. - 1083-351X. ; 280:41, s. 34832-34839
  • Journal article (peer-reviewed)abstract
    • Antimicrobial peptides are important effectors of the innate immune system. These peptides belong to a multifunctional group of molecules that apart from their antibacterial activities also interact with mammalian cells and glycosaminoglycans and control chemotaxis, apoptosis, and angiogenesis. Here we demonstrate a novel antimicrobial activity of the heparin-binding and cell-binding domain 5 of high molecular weight kininogen. Antimicrobial epitopes of domain 5 were characterized by analysis of overlapping peptides. A peptide, HKH20 (His(479) - His(498)), efficiently killed the Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa and the Gram-positive Enterococcus faecalis. Fluorescence microscopy and electron microscopy demonstrated that HKH20 binds to and induces breaks in bacterial membranes. Furthermore, no discernible hemolysis or membrane-permeabilizing effects on eukaryotic cells were noted. Proteolytic degradation of high molecular weight kininogen by neutrophil-derived proteases as well as the metalloproteinase elastase from P. aeruginosa yielded fragments comprising HKH20 epitopes, indicating that kininogen-derived antibacterial peptides are released during proteolysis.
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3.
  • Pasupuleti, Mukesh, et al. (author)
  • Preservation of Antimicrobial Properties of Complement Peptide C3a, from Invertebrates to Humans
  • 2007
  • In: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 282:4, s. 2520-2528
  • Journal article (peer-reviewed)abstract
    • The human anaphylatoxin peptide C3a, generated during complement activation, exerts antimicrobial effects. Phylogenetic analysis, sequence analyses, and structural modeling studies paired with antimicrobial assays of peptides from known C3a sequences showed that, in particular in vertebrate C3a, crucial structural determinants governing antimicrobial activity have been conserved during the evolution of C3a. Thus, regions of the ancient C3a from Carcinoscorpius rotundicauda as well as corresponding parts of human C3a exhibited helical structures upon binding to bacterial lipopolysaccharide permeabilized liposomes and were antimicrobial against Gram-negative and Gram-positive bacteria. Human C3a and C4a (but not C5a) were antimicrobial, in concert with the separate evolutionary development of the chemotactic C5a. Thus, the results demonstrate that, notwithstanding a significant sequence variation, functional and structural constraints imposed on C3a during evolution have preserved critical properties governing antimicrobial activity.
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4.
  • Carré, Helena, 1979-, et al. (author)
  • Improved contact tracing for Chlamydia trachomatis with experienced tracers, tracing for one year back in time and interviewing by phone in remote areas
  • 2008
  • In: Sexually Transmitted Infections. - : BMJ publishing. - 1368-4973 .- 1472-3263. ; 84:3, s. 239-242
  • Journal article (peer-reviewed)abstract
    • Objectives: To evaluate the Swedish model for contact tracing and especiallythe "Västerbotten model" with centralised, extended contactinterview periods, sometimes by telephone.Methods: Using questionnaires, the contact tracing and interview procedurewas evaluated during 2002, followed by an evaluation of contactinterviewing by phone in 2005–6.Results: Patients with diagnosed Chlamydia trachomatis infection reportedon average 2.5 sexual contacts, 3.0 contacts when contact interviewingwas performed at the clinic, and 2.3 contacts when performedby phone. 65% of the sexual contacts with a known test resultwere infected.Conclusion: Centralised contact tracing, exploring the sexual history forat least 12 months back in time, shows good results. Combinedwith screening of certain risk groups it is probably one effectiveway of preventing C trachomatis infections. Preventing C trachomatisby primary prevention such as information and counselling is,however, still of great importance.
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  • Bruze, Magnus, et al. (author)
  • Chemical skin burns
  • 2006
  • In: Handbook of irritant dermatitis. - 9783540009030 - 3540009035 ; , s. 53-53
  • Book chapter (other academic/artistic)
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9.
  • Gruvberger, Birgitta, et al. (author)
  • Allergens Exposure Assessment
  • 2006
  • In: Contact Dermatitis. - 9783540244714 - 3540244719 ; , s. 413-413
  • Book chapter (other academic/artistic)
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  • Result 1-10 of 574
Type of publication
journal article (457)
doctoral thesis (41)
book chapter (27)
conference paper (24)
research review (16)
book (3)
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reports (2)
other publication (2)
licentiate thesis (2)
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Type of content
peer-reviewed (446)
other academic/artistic (127)
pop. science, debate, etc. (1)
Author/Editor
Bruze, Magnus (60)
Faergemann, Jan, 194 ... (28)
Wennberg, Ann-Marie, ... (27)
Gruvberger, Birgitta (26)
Schmidtchen, Artur (25)
Isaksson, Marléne (22)
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Gustafsson, Per M., ... (21)
Svensson, Åke (19)
Zimerson, Erik (18)
Malmsten, Martin (17)
Wennergren, Göran, 1 ... (15)
Barregård, Lars, 194 ... (14)
Pivarcsi, Andor (14)
Hindsén, Monica (13)
Wallengren, Joanna (12)
Svedman, Cecilia (12)
Paoli, John, 1975 (11)
Ericson, Marica B, 1 ... (11)
Goossens, An (10)
Goossens, A (10)
Svanberg, Katarina (9)
Möller, Halvor (9)
Unemo, Magnus (9)
Kemény, Lajos (9)
Hansson, Christer (8)
Lindberg, Magnus (8)
Menne, T. (7)
Grip, Lars, 1952 (7)
Bäckhed, Fredrik, 19 ... (7)
Mörgelin, Matthias (7)
Nilsson, Staffan, 19 ... (7)
Andersson-Engels, St ... (7)
Bendsöe, Niels (7)
Björk, Jonas (7)
Stenberg, Berndt (7)
Karlberg, Ann-Theres ... (7)
Andersen, KE (7)
Johansson, Ann (7)
Pontén, Ann (7)
Sillén, Ulla, 1946 (6)
Rosengren, Annika, 1 ... (6)
Forslund, Ola (6)
Johansson, Saga (6)
Börje, Anna, 1961 (6)
Berne, Berit (6)
Bergbrant, Ing-Marie ... (6)
Enerbäck, Charlotta, ... (6)
Rosdahl, Inger (6)
Bergendorff, Ola (6)
Széll, Márta (6)
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University
University of Gothenburg (303)
Lund University (188)
Uppsala University (81)
Karolinska Institutet (62)
Umeå University (28)
Linköping University (25)
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Örebro University (23)
Chalmers University of Technology (19)
University of Borås (5)
Malmö University (3)
Stockholm University (2)
Mid Sweden University (2)
Linnaeus University (2)
Royal Institute of Technology (1)
Halmstad University (1)
Mälardalen University (1)
University of Skövde (1)
Karlstad University (1)
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Language
English (525)
Swedish (47)
German (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (574)
Social Sciences (39)
Natural sciences (24)
Engineering and Technology (1)

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