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- Krypotou, Emilia, et al.
(author)
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Control of Bacterial Virulence through the Peptide Signature of the Habitat
- 2019
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In: Cell Reports. - : Elsevier. - 2211-1247. ; 26:7, s. 1815-1827
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Journal article (peer-reviewed)abstract
- To optimize fitness, pathogens selectively activate their virulence program upon host entry. Here, we report that the facultative intracellular bacterium Listeria monocytogenes exploits exogenous oligopeptides, a ubiquitous organic N source, to sense the environment and control the activity of its virulence transcriptional activator, PrfA. Using a genetic screen in adsorbent- treated ( PrfA-inducing) medium, we found that PrfA is functionally regulated by the balance between activating and inhibitory nutritional peptides scavenged via the Opp transport system. Activating peptides provide essential cysteine precursor for the PrfA-inducing cofactor glutathione ( GSH). Non-cysteine-containing peptides cause promiscuous PrfA inhibition. Biophysical and co-crystallization studies reveal that peptides inhibit PrfA through steric blockade of the GSH binding site, a regulation mechanism directly linking bacterial virulence and metabolism. L. monocytogenes mutant analysis in macrophages and our functional data support a model in which changes in the balance of antagonistic Oppimported oligopeptides promote PrfA induction intra-cellularly and PrfA repression outside the host.
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- Dylman, Alexandra S, et al.
(author)
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The effect of language and cultural context on the BIG-5 personality inventory in bilinguals
- 2023
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In: Journal of Multilingual and Multicultural Development. - : Informa UK Limited. - 0143-4632 .- 1747-7557.
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Journal article (peer-reviewed)abstract
- Studies have found that bilinguals respond differently to personality measures in their two languages, indicating that bilinguals change their personality as they switch between their two languages and/or cultures. Across two experiments, we attempted to investigate the effect of language and culture separately on how bilingual speakers rate themselves on the personality dimensions on the Big-5 Personality Inventory. Swedish speakers were asked to imagine applying for a job either at a Swedish (home country/own culture) or an American (foreign country/culture) company, and they responded to the Big-5 questions in either their first language Swedish, or their second language English, in a 2 by 2 design. Overall, differences on several of the personality dimensions were found, mainly affected by the language factor, generally replicating previous research. These results suggest that separate processes may be driving previously found differences on personality measures in bilinguals' two languages to some extent, and that these processes affect the personality dimensions (as measured by the Big-5 personality inventory) differently, even if the language variable seems to be the stronger indicator.
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- Vejbrink Kildal, Villiam, et al.
(author)
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Preoperative assessment of depressor anguli oris to prevent myectomy failure : An anatomical study using high-resolution ultrasound
- 2024
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In: Journal of Plastic, Reconstructive & Aesthetic Surgery. - : Elsevier. - 1748-6815 .- 1878-0539. ; 88, s. 296-302
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Journal article (peer-reviewed)abstract
- Background: Myectomies of the lower lip depressor muscles have unexplained high failure rates. This study aimed to examine the depressor anguli oris (DAO) muscle using high-resolution ultrasound to identify potential anatomical explanations for surgical failures and to determine the accuracy of utilizing preoperative ultrasound assessment to improve myectomies.Methods: Anatomical features of DAO and the surrounding anatomy were examined in 38 hemifaces of human body donors using high-resolution ultrasound and dissection.Results: The ultrasound and dissection measurements showed the DAO muscle width to be 16.2 ± 2.9 versus 14.5 ± 2.5 mm, respectively, and the location of the lateral muscle border 54.4 ± 5.7 versus 52.3 ± 5.4 mm lateral to the midline. In 60% of the cases, the facial artery was either completely covered by lateral DAO muscle fibers or was found to be in direct contact with the lateral border. Significant muscle fiber continuity was present between the DAO and surrounding muscles in 5% of cases, whereas continuity between the depressor labii inferioris and surrounding muscles was considerably more common and pronounced.Conclusions: High-resolution ultrasound can accurately reveal important preoperative anatomical information in myectomies. Two potential explanations for the surgical failures were discovered: an overlap of lateral DAO muscle fibers over the facial artery could lead to inadequate resections and continuity with the surrounding muscles might lead to muscle function takeover despite adequate resections. Both can be uncovered preoperatively by the surgeon through a brief, directed ultrasound examination, which may allow for modification of the surgical plan to reduce surgical failure.
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- Bulla, Mattia, et al.
(author)
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White dwarf deflagrations for Type Iax supernovae : polarisation signatures from the explosion and companion interaction
- 2020
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 635
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Journal article (peer-reviewed)abstract
- Growing evidence suggests that Type Iax supernovae might be the result of thermonuclear deflagrations of Chandrasekhar-mass white dwarfs in binary systems. We carry out Monte Carlo radiative transfer simulations and predict spectropolarimetric features originating from the supernova explosion and subsequent ejecta interaction with the companion star. Specifically, we calculate viewing-angle dependent flux and polarisation spectra for a 3D model simulating the deflagration of a Chandrasekhar-mass white dwarf and, for a second model, simulating the ejecta interaction with a main-sequence star. We find that the intrinsic signal is weakly polarised and only mildly viewing-angle dependent, owing to the overall spherical symmetry of the explosion and the depolarising contribution of iron-group elements dominating the ejecta composition. The interaction with the companion star carves out a cavity in the ejecta and produces a detectable, but modest signal that is significant only at relatively blue wavelengths (less than or similar to 5000 angstrom). In particular, increasingly fainter and redder spectra are predicted for observer orientations further from the cavity, while a modest polarisation signal P similar to 0.2 per cent is found at blue wavelengths for orientations 30 degrees and 45 degrees away from the cavity. We find a reasonable agreement between the interaction model viewed from these orientations and spectropolarimetric data of SN 2005hk and interpret the maximum-light polarisation signal seen at blue wavelengths for this event as a possible signature of the ejecta-companion interaction. We encourage further polarimetric observations of SNe Iax to test whether our results can be extended and generalised to the whole SN Iax class.
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