| 11. |
- Jonsson, F., et al.
(författare)
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Paths of adversity linking adolescent socioeconomic conditions to adult functional somatic symptoms
- 2016
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Ingår i: European Journal of Public Health. - : Oxford University Press. - 1101-1262 .- 1464-360X. ; 26:Suppl 1, s. 227-227
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Tidskriftsartikel (refereegranskat)abstract
- Background: While research examining the health impact of early socioeconomic conditions suggests that effects may exist independently of or jointly with adult socioeconomic position, studies exploring other pathways are few. Following a chain of risk life course model, this study examine if the socioeconomic conditions of the family contributes to an adverse social and material environment across life ultimately affecting functional somatic symptoms in adulthood.Methods: Mediation was examined using path analysis on prospective data from a sample of 987 individuals residing in Luleå, Sweden in 1981 and who answered surveys at age 16, 21, 30 and 42. Early socioeconomic conditions was assessed at age 16 by using the parents occupation. The participant’s own occupation was measured at age 21 and 30. At age 21 and 30, social adversity comprised of items pertaining to stressful life events, while material adversity included items of unfavorable economic conditions. Functional somatic symptoms was examined at age 42 as a summary of self-reported physical symptoms, palpitation and sleeping difficulties occurring during the last 12 months.Results: The results suggested that the association between socioeconomic conditions at age 16 and functional somatic symptoms at age 42 (r = .068) could be explained by two plausible pathways. Through own class at age 21 and then through material (B = .064, 95% CI = .004 – .123) and social adversity (B = .067, 95% CI = .019 – .114) at age 30.Conclusions: Growing up in an unfavorable socioeconomic setting might be a source for later adversities, and these might largely explain the effects of early disadvantage on later health. Thus, improved social and financial living conditions for people from poor backgrounds could avert adult stress-related health problems.Key messages:Chains of life events may be central to understand socioeconomic health effectsBreaking life course chains might avert adult health effects of early disadvantage
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| 12. |
- Landstedt, Evelina, et al.
(författare)
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Longitudinal associations between social relationships at age 30 and internalising symptoms at age 42 : Findings from the Northern Swedish Cohort
- 2016
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Ingår i: International Journal of Public Health. - : Springer Nature. - 1661-8556 .- 1661-8564. ; 61:1, s. 75-81
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Little is known on long-term consequences of poor social relationships in adulthood. The study aimed to examine associations between social relationships at age 30 and internalising symptoms at age 42.METHODS: Data was drawn from four waves of the Northern Swedish cohort (n = 1001, 94 % response rate). The outcome internalising symptoms was measured by a composite index of depressiveness and anxiety. A cumulative measure was constructed to reflect various aspects of social relationships. Multivariate ordinal logistic regressions were used, controlling for socioeconomic indicators and previous level of internalising symptoms.RESULTS: An accumulation of poor social relationships indicators at age 30 is related to internalising symptoms at age 42 in women (OR 1.30; CI 1.11-1.52) and men (OR 1.17; CI 1.02-1.36). The associations remained significant after adjustment for covariates.CONCLUSIONS: Poor quality of social relationships at age 30 can predict internalising symptoms 12 years later in both men and women even when previous mental health as well as financial disadvantage is accounted for. More research is required to further examine pathways and mechanisms as well as suitable interventions.
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| 13. |
- Psonka-Antonczyk, Katarzyna M., et al.
(författare)
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Nanoscale Structure and Spectroscopic Probing of A beta 1-40 Fibril Bundle Formation
- 2016
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Ingår i: Frontiers in Chemistry. - : Frontiers Research Foundation. - 2296-2646. ; 4
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Tidskriftsartikel (refereegranskat)abstract
- Amyloid plaques composed of fibrillar Amyloid-beta (A beta) are hallmarks of Alzheimers disease. However, A beta fibrils are morphologically heterogeneous. Conformation sensitive luminescent conjugated oligothiophenes (LCOs) are versatile tools for monitoring such fibril polymorphism in vivo and in vitro. Biophysical methods applied on in vitro generated A beta fibrils, stained with LCOs with different binding and fluorescence properties, can be used to characterize the A beta fibrillation in depth, far beyond that possible for in vivo generated amyloid plaques. In this study, in vitro fibrillation of the A beta 1-40 peptide was monitored by time-lapse transmission electron microscopy, LCO fluorescence, and atomic force microscopy. Differences in the LCO binding in combination with nanoscale imaging revealed that spectral variation correlated with fibrils transforming from solitary filaments (empty set similar to 2.5 nm) into higher order bundled structures (empty set similar to 5 nm). These detailed in vitro experiments can be used to derive data that reflects the heterogeneity of in vivo generated A beta plaques observed by LCO fluorescence. Our work provides new structural basis for targeted drug design and molecular probe development for amyloid imaging.
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| 14. |
- Rajaleid, Kristiina, et al.
(författare)
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Social adversities in adolescence predict unfavourable trajectories of internalized mental health symptoms until middle age : results from the Northern Swedish Cohort
- 2016
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Ingår i: European Journal of Public Health. - : Oxford University Press (OUP). - 1101-1262 .- 1464-360X. ; 26:1, s. 23-29
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Experiencing adversities during upbringing has short-term and long-term effects on mental health. This study aims to explore how social adversities in adolescence predict trajectories of internalized mental health symptoms (IMHS), from adolescence and onward until middle age.METHODS: Based on 1040 individuals from the Northern Swedish Cohort Study, a community-based cohort with 27 years of follow-up. We applied latent class growth analysis to extract trajectories of IMHS between ages 16 and 43. Multinomial logistic regression was used to study the association of social adversities (residential mobility, residential crowding, parental loss, unemployment of a parent, physical illness of a parent, mental illness or alcohol problems of a parent) in adolescence with IMHS trajectories.RESULTS: Five trajectory classes were identified: 'very low stable' (26% of the sample), 'low stable' (58%), 'moderate stable' (5%), 'increasing' (8%) and 'high decreasing' (3%). Both in men and women, reporting social adversities at the age of 16 increased the risk of belonging to the classes with less favourable development of IMHS. Reporting adversities was positively associated with the initial level of the IMHS trajectories. Thus it seems that the influence of adversities is more pronounced during the early years of follow-up and is attenuated over time.CONCLUSION: Experiencing social adversities in adolescence increases the risk of entering unfavourable developmental trajectories of mental health until middle age.
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| 15. |
- Wennberg, Maria, et al.
(författare)
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Irregular eating of meals in adolescence and the metabolic syndrome in adulthood : results from a 27-year prospective cohort
- 2016
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Ingår i: Public Health Nutrition. - : Cambridge University Press. - 1368-9800 .- 1475-2727. ; 19:3, s. 667-673
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The objective was to investigate whether irregular eating of meals in adolescence predicts the metabolic syndrome and its components in adulthood, and if any specific meal is of particular importance. Design: Prospective cohort study with 27 years of follow-up. Information on meals (breakfast, school lunch and dinner with family), lifestyle (alcohol consumption, smoking habits, physical activity, consumption of sweets and pastries) at age 16 years was assessed from questionnaires, and presence or not of the metabolic syndrome and its components were defined at age 43 years in 889 participants (82.1 % of total cohort). Logistic regression was used to calculate odds ratios and confidence intervals. Setting: The Northern Swedish Cohort; all school-leavers of the 9th grade in the town Lulea in 1981. Subjects: Adolescents (age 16 years). Results: Irregular eating of meals at age 16 years was associated with higher prevalence of the metabolic syndrome at age 43 years (OR=1.74; 95 % CI 1.12, 2.71), but this was explained by concurrent unhealthy lifestyle at age 16 years. Poor breakfast at age 16 years was the only meal associated with the metabolic syndrome at age 43 years, independent of other meals, BMI (kg/m2) and lifestyle at age 16 years (OR = 1.67; 95 % CI 1.00, 2.80). Conclusions: Irregular eating of meals in adolescence predicted the metabolic syndrome in adulthood, but not independently of BMI and lifestyle in adolescence. Poor breakfast in adolescence was the only specific meal associated with future metabolic syndrome, even after adjustments. Breakfast eating should be encouraged in adolescence.
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