SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "L773:1061 4036 OR L773:1546 1718 srt2:(2015-2019)"

Search: L773:1061 4036 OR L773:1546 1718 > (2015-2019)

  • Result 11-20 of 193
Sort/group result
   
EnumerationReferenceCoverFind
11.
  •  
12.
  •  
13.
  • Cesarini, David, et al. (author)
  • Genotype-covariate interaction effects and the heritability of adult body mass index
  • 2017
  • In: Nature Genetics. - : Nature Research (part of Springer Nature). - 1061-4036 .- 1546-1718. ; 49:8, s. 1174-1181
  • Journal article (peer-reviewed)abstract
    • Obesity is a worldwide epidemic, with major health and economic costs. Here we estimate heritability for body mass index (BMI) in 172,000 sibling pairs and 150,832 unrelated individuals and explore the contribution of genotype-covariate interaction effects at common SNP loci. We find evidence for genotype-age interaction (likelihood ratio test (LRT) = 73.58, degrees of freedom (df) = 1, P = 4.83 × 10-18), which contributed 8.1% (1.4% s.e.) to BMI variation. Across eight self-reported lifestyle factors, including diet and exercise, we find genotype-environment interaction only for smoking behavior (LRT = 19.70, P = 5.03 × 10-5 and LRT = 30.80, P = 1.42 × 10-8), which contributed 4.0% (0.8% s.e.) to BMI variation. Bayesian association analysis suggests that BMI is highly polygenic, with 75% of the SNP heritability attributable to loci that each explain <0.01% of the phenotypic variance. Our findings imply that substantially larger sample sizes across ages and lifestyles are required to understand the full genetic architecture of BMI.
  •  
14.
  •  
15.
  •  
16.
  •  
17.
  •  
18.
  • Chu, Audrey Y, et al. (author)
  • Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation
  • 2017
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 49:1, s. 125-130
  • Journal article (peer-reviewed)abstract
    • Variation in body fat distribution contributes to the metabolic sequelae of obesity. The genetic determinants of body fat distribution are poorly understood. The goal of this study was to gain new insights into the underlying genetics of body fat distribution by conducting sample-size-weighted fixed-effects genome-wide association meta-analyses in up to 9,594 women and 8,738 men of European, African, Hispanic and Chinese ancestry, with and without sex stratification, for six traits associated with ectopic fat (hereinafter referred to as ectopic-fat traits). In total, we identified seven new loci associated with ectopic-fat traits (ATXN1, UBE2E2, EBF1, RREB1, GSDMB, GRAMD3 and ENSA; P < 5 × 10(-8); false discovery rate < 1%). Functional analysis of these genes showed that loss of function of either Atxn1 or Ube2e2 in primary mouse adipose progenitor cells impaired adipocyte differentiation, suggesting physiological roles for ATXN1 and UBE2E2 in adipogenesis. Future studies are necessary to further explore the mechanisms by which these genes affect adipocyte biology and how their perturbations contribute to systemic metabolic disease.
  •  
19.
  •  
20.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 11-20 of 193
Type of publication
journal article (192)
other publication (1)
Type of content
peer-reviewed (184)
other academic/artistic (9)
Author/Editor
Stefansson, K (28)
Metspalu, A (22)
Uitterlinden, AG (20)
Lind, Lars (19)
Esko, T (19)
Boomsma, DI (18)
show more...
Gudnason, V (17)
Martin, NG (17)
O'Donovan, MC (17)
Sullivan, PF (16)
van Duijn, CM (16)
Hofman, A (16)
Hayward, C. (16)
Amin, N (15)
Ripke, S (15)
Gieger, C (15)
Metspalu, Andres (15)
Esko, Tõnu (15)
Morris, Andrew P. (15)
Hottenga, JJ (14)
Smith, AV (14)
Psaty, BM (14)
Launer, LJ (14)
Lehtimaki, T. (14)
Stefansson, Kari (14)
Mahajan, Anubha (14)
Thorsteinsdottir, U (14)
Milani, L (14)
Harris, TB (14)
Melander, Olle (13)
Montgomery, GW (13)
Nolte, IM (13)
Palotie, A (13)
Thorleifsson, G (13)
Jarvelin, MR (13)
Owen, MJ (13)
Willemsen, G (12)
Schmidt, R (12)
Easton, DF (12)
Snieder, H. (12)
Neale, BM (12)
Gieger, Christian (12)
Salomaa, V (12)
Luan, Jian'an (12)
Franke, L (12)
Hayward, Caroline (12)
Chasman, DI (12)
Ridker, PM (12)
Lindgren, Cecilia M. (12)
Ingelsson, Erik, 197 ... (12)
show less...
University
Karolinska Institutet (137)
Uppsala University (52)
Lund University (44)
Umeå University (29)
University of Gothenburg (19)
Stockholm School of Economics (7)
show more...
Stockholm University (6)
Swedish University of Agricultural Sciences (6)
Örebro University (3)
Linköping University (2)
Jönköping University (2)
Mid Sweden University (2)
Högskolan Dalarna (2)
Royal Institute of Technology (1)
Chalmers University of Technology (1)
show less...
Language
English (193)
Research subject (UKÄ/SCB)
Medical and Health Sciences (97)
Natural sciences (34)
Agricultural Sciences (3)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view