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Träfflista för sökning "L773:1932 7420 OR L773:1550 4131 srt2:(2010-2014)"

Search: L773:1932 7420 OR L773:1550 4131 > (2010-2014)

  • Result 11-20 of 58
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  • Dong, Mei, et al. (author)
  • Cold Exposure Promotes Atherosclerotic Plaque Growth and Instability via UCP1-Dependent Lipolysis
  • 2013
  • In: Cell Metabolism. - : Elsevier (Cell Press). - 1550-4131 .- 1932-7420. ; 18:1, s. 118-129
  • Journal article (peer-reviewed)abstract
    • Molecular mechanisms underlying the cold-associated high cardiovascular risk remain unknown. Here, we show that the cold-triggered food-intake-independent lipolysis significantly increased plasma levels of small low-density lipoprotein (LDL) remnants, leading to accelerated development of atherosclerotic lesions in mice. In two genetic mouse knockout models (apolipoprotein E-/- [ApoE(-/-)] and LDL receptor(-/-) [Ldlr(-/-)] mice), persistent cold exposure stimulated atherosclerotic plaque growth by increasing lipid deposition. Furthermore, marked increase of inflammatory cells and plaque-associated microvessels were detected in the cold-acclimated ApoE(-/-) and Ldlr(-/-) mice, leading to plaque instability. Deletion of uncoupling protein 1 (UCP1), a key mitochondrial protein involved in thermogenesis in brown adipose tissue (BAT), in the ApoE(-/-) strain completely protected mice from the cold-induced atherosclerotic lesions. Cold acclimation markedly reduced plasma levels of adiponectin, and systemic delivery of adiponectin protected ApoE(-/-) mice from plaque development. These findings provide mechanistic insights on low-temperature-associated cardiovascular risks.
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  • Enerbäck, Sven, 1958 (author)
  • An enzymatic chromatin switch that directs formation of active brown fat
  • 2014
  • In: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 19:1, s. 3-4
  • Journal article (peer-reviewed)abstract
    • How is the recruitment of brown adipocytes regulated? Ohno et al. (2013) show that the euchromatic histone-lysine N-metyltransferase 1 (EHMT1) is essential for the specification of the brown adipocyte fate, a finding with important implications for the pathophysiology of obesity and obesity-related maladies. © 2014 Elsevier Inc.
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18.
  • Enerbäck, Sven, 1958 (author)
  • Human brown adipose tissue.
  • 2010
  • In: Cell metabolism. - : Elsevier BV. - 1932-7420 .- 1550-4131. ; 11:4, s. 248-52
  • Journal article (peer-reviewed)abstract
    • The BAT organ is unique in that it has evolved to safely dissipate large amounts of chemical energy--a quality that might be harnessed to help humans deal with a dangerously hypercaloric environment and still remain in good health.
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  • Gao, Tao, et al. (author)
  • Pdx1 Maintains beta Cell Identity and Function by Repressing an alpha Cell Program
  • 2014
  • In: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 19:2, s. 259-271
  • Journal article (peer-reviewed)abstract
    • Pdx1 is a homeobox-containing transcription factor that plays a key role in pancreatic development and adult beta cell function. In this study, we traced the fate of adult beta cells after Pdx1 deletion. As expected, beta-cell-specific removal of Pdx1 resulted in severe hyperglycemia within days. Surprisingly, a large fraction of Pdx1-deleted cells rapidly acquired ultrastructural and physiological features of a cells, indicating that a robust cellular reprogramming had occurred. Reprogrammed cells exhibited a global transcriptional shift that included derepression of the alpha cell transcription factor MafB, resulting in a transcriptional profile that closely resembled that of alpha cells. These findings indicate that Pdx1 acts as a master regulator of beta cell fate by simultaneously activating genes essential for beta cell identity and repressing those associated with alpha cell identity. We discuss the significance of these findings in the context of the emerging notion that loss of beta cell identity contributes to the pathogenesis of type 2 diabetes.
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  • Result 11-20 of 58
Type of publication
journal article (56)
research review (2)
Type of content
peer-reviewed (54)
other academic/artistic (4)
Author/Editor
Larsson, NG (8)
Renström, Erik (5)
Cannon, Barbara (4)
Nedergaard, Jan (4)
Trifunovic, A (4)
Zhang, Enming (4)
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Salehi, S Albert (3)
Lyssenko, Valeriya (3)
Groop, Leif (3)
Taneera, Jalal (3)
Rosengren, Anders (3)
Wibom, R (3)
Eliasson, Lena (3)
Enerbäck, Sven, 1958 (3)
Krus, Ulrika (3)
Larsson, Nils-Göran (3)
Gustafsson, Claes M, ... (3)
Mourier, A (3)
Esguerra, Jonathan (3)
Ruzzenente, B (3)
Berggren, PO (2)
Bäckhed, Fredrik, 19 ... (2)
Zierath, JR (2)
Holmgren, A (2)
Hansson, Ola (2)
Blom, Anna (2)
Zhou, Yuedan (2)
Vikman, Petter (2)
Terzioglu, M (2)
Rudling, M (2)
Canto, C. (2)
Cao, Yihai (2)
Partridge, L (2)
Petersén, Åsa (2)
Egan, B (2)
Wollheim, Claes (2)
Edgar, D (2)
Auwerx, J (2)
Parikh, Hemang (2)
Kukat, C (2)
Habermann, B (2)
Halliwell, B (2)
Chang, CJ (2)
Kalyanaraman, B (2)
Murphy, MP (2)
Winterbourn, CC (2)
Belousov, V (2)
Jing, Xingjun (2)
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Rhee, SG (2)
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University
Karolinska Institutet (34)
University of Gothenburg (12)
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The Swedish School of Sport and Health Sciences (1)
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Language
English (58)
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Medical and Health Sciences (24)
Natural sciences (5)
Agricultural Sciences (1)

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