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Träfflista för sökning "WFRF:(Coates R. C.) srt2:(2010-2014)"

Search: WFRF:(Coates R. C.) > (2010-2014)

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11.
  • Zeng, R., et al. (author)
  • Breed Distribution of SOD1 Alleles Previously Associated with Canine Degenerative Myelopathy
  • 2014
  • In: Journal of Veterinary Internal Medicine. - : Wiley. - 0891-6640 .- 1939-1676. ; 28:2, s. 515-521
  • Journal article (peer-reviewed)abstract
    • Background Previous reports associated 2 mutant SOD1 alleles (SOD1:c.118A and SOD1:c.52T) with degenerative myelopathy in 6 canine breeds. The distribution of these alleles in other breeds has not been reported. Objective To describe the distribution of SOD1:c.118A and SOD1:c.52T in 222 breeds. Animals DNA from 33,747 dogs was genotyped at SOD1:c.118, SOD1:c.52, or both. Spinal cord sections from 249 of these dogs were examined. Methods Retrospective analysis of 35,359 previously determined genotypes at SOD1:c.118G>A or SOD1:c.52A>T and prospective survey to update the clinical status of a subset of dogs from which samples were obtained with a relatively low ascertainment bias. Results The SOD1:c.118A allele was found in cross-bred dogs and in 124 different canine breeds whereas the SOD1:c.52T allele was only found in Bernese Mountain Dogs. Most of the dogs with histopathologically confirmed degenerative myelopathy were SOD1:c.118A homozygotes, but 8 dogs with histopathologically confirmed degenerative myelopathy were SOD1:c.118A/G heterozygotes and had no other sequence variants in their SOD1 amino acid coding regions. The updated clinical conditions of dogs from which samples were obtained with a relatively low ascertainment bias suggest that SOD1:c.118A homozygotes are at a much higher risk of developing degenerative myelopathy than are SOD1:c.118A/G heterozygotes. Conclusions and Clinical Importance We conclude that the SOD1:c.118A allele is widespread and common among privately owned dogs whereas the SOD1:c.52T allele is rare and appears to be limited to Bernese Mountain Dogs. We also conclude that breeding to avoid the production of SOD1:c.118A homozygotes is a rational strategy.
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12.
  • Romanelli, N., et al. (author)
  • Outflow and plasma acceleration in Titan's induced magnetotail : Evidence of magnetic tension forces
  • 2014
  • In: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 119:12
  • Journal article (peer-reviewed)abstract
    • Cassini plasma wave and particle observations are combined with magnetometer measurements to study Titan's induced magnetic tail. In this study, we report and analyze the plasma acceleration in Titan's induced magnetotail observed in flybys T17, T19, and T40. Radio and Plasma Wave Science observations show regions of cold plasma with electron densities between 0.1 and a few tens of electrons per cubic centimeter. The Cassini Plasma Spectrometer (CAPS)-ion mass spectrometer (IMS) measurements suggest that ionospheric plasma in this region is composed of ions with masses ranging from 15 to 17 amu and from 28 to 31 amu. From these measurements, we determine the bulk velocity of the plasma and the Alfven velocity in Titan's tail region. Finally, a Walen test of such measurements suggest that the progressive acceleration of the ionospheric plasma shown by CAPS can be interpreted in terms of magnetic tension forces.
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  • Result 11-12 of 12

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