SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Lecoeur Cecile) srt2:(2010-2014)"

Search: WFRF:(Lecoeur Cecile) > (2010-2014)

  • Result 11-12 of 12
Sort/group result
   
EnumerationReferenceCoverFind
11.
  • Speliotes, Elizabeth K., et al. (author)
  • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
  • 2010
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948
  • Journal article (peer-reviewed)abstract
    • Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
  •  
12.
  • Sverrisdóttir, Oddný Ósk, et al. (author)
  • Direct Estimates of Natural Selection in Iberia Indicate Calcium Absorption Was Not the Only Driver of Lactase Persistence in Europe
  • 2014
  • In: Molecular biology and evolution. - : Oxford University Press (OUP). - 0737-4038 .- 1537-1719. ; 31:4, s. 975-983
  • Journal article (peer-reviewed)abstract
    • Lactase persistence (LP) is a genetically determined trait whereby the enzyme lactase is expressed throughout adult life. Lactase is necessary for the digestion of lactose-the main carbohydrate in milk-and its production is downregulated after the weaning period in most humans and all other mammals studied. Several sources of evidence indicate that LP has evolved independently, in different parts of the world over the last 10,000 years, and has been subject to strong natural selection in dairying populations. In Europeans, LP is strongly associated with, and probably caused by, a single C to T mutation 13,910 bp upstream of the lactase (LCT) gene (-13,910*T). Despite a considerable body of research, the reasons why LP should provide such a strong selective advantage remain poorly understood. In this study, we examine one of the most widely cited hypotheses for selection on LP-that fresh milk consumption supplemented the poor vitamin D and calcium status of northern Europe's early farmers (the calcium assimilation hypothesis). We do this by testing for natural selection on -13,910*T using ancient DNA data from the skeletal remains of eight late Neolithic Iberian individuals, whom we would not expect to have poor vitamin D and calcium status because of relatively high incident UVB light levels. None of the eight samples successfully typed in the study had the derived T-allele. In addition, we reanalyze published data from French Neolithic remains to both test for population continuity and further examine the evolution of LP in the region. Using simulations that accommodate genetic drift, natural selection, uncertainty in calibrated radiocarbon dates, and sampling error, we find that natural selection is still required to explain the observed increase in allele frequency. We conclude that the calcium assimilation hypothesis is insufficient to explain the spread of LP in Europe.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 11-12 of 12
Type of publication
journal article (12)
Type of content
peer-reviewed (12)
Author/Editor
Froguel, Philippe (12)
Wareham, Nicholas J. (10)
Kuusisto, Johanna (9)
Laakso, Markku (9)
McCarthy, Mark I (9)
Loos, Ruth J F (9)
show more...
Langenberg, Claudia (8)
Boehnke, Michael (8)
Barroso, Ines (8)
Kovacs, Peter (8)
Groop, Leif (7)
Mohlke, Karen L (7)
Ingelsson, Erik (7)
Tuomilehto, Jaakko (7)
Luan, Jian'an (7)
Deloukas, Panos (6)
Isomaa, Bo (6)
Pedersen, Oluf (6)
Hansen, Torben (6)
Hu, Frank B. (6)
Thorleifsson, Gudmar (6)
Stefansson, Kari (6)
Shuldiner, Alan R. (6)
Meyre, David (6)
Wilson, James F. (6)
Johnson, Toby (6)
Tuomi, Tiinamaija (5)
Salomaa, Veikko (5)
Perola, Markus (5)
Campbell, Harry (5)
Rudan, Igor (5)
North, Kari E. (5)
van Duijn, Cornelia ... (5)
Qi, Lu (5)
Ripatti, Samuli (5)
Thorsteinsdottir, Un ... (5)
Mangino, Massimo (5)
Willemsen, Gonneke (5)
Wichmann, H. Erich (5)
Boomsma, Dorret I. (5)
Jarvelin, Marjo-Riit ... (5)
Walker, Mark (5)
Hicks, Andrew A. (5)
Pramstaller, Peter P ... (5)
Wright, Alan F. (5)
Rivadeneira, Fernand ... (5)
Zhao, Jing Hua (5)
Hofman, Albert (5)
Smith, George Davey (5)
Pouta, Anneli (5)
show less...
University
Uppsala University (10)
Lund University (7)
Karolinska Institutet (7)
University of Gothenburg (5)
Umeå University (4)
Stockholm University (1)
show more...
Örebro University (1)
show less...
Language
English (12)
Research subject (UKÄ/SCB)
Medical and Health Sciences (9)
Natural sciences (3)
Humanities (1)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view