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Träfflista för sökning "WFRF:(Rice S) srt2:(2015-2019)"

Search: WFRF:(Rice S) > (2015-2019)

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11.	Polimanti, R, et al. (author) Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium 2019 In: Psychological medicine. - 1469-8978. ; 49:7, s. 1218-1226 Journal article (peer-reviewed)
12.	Winkler, TW, et al. (author) The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study 2015 In: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 11:10, s. e1005378- Journal article (peer-reviewed)
13.	O'Dushlaine, C, et al. (author) Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways 2015 In: Nature neuroscience. - : Springer Science and Business Media LLC. - 1546-1726 .- 1097-6256. ; 18:2, s. 199-209 Journal article (peer-reviewed)
14.	Grove, J, et al. (author) Identification of common genetic risk variants for autism spectrum disorder 2019 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 51:3, s. 431- Journal article (peer-reviewed)
15.	Musliner, KL, et al. (author) Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish Population 2019 In: JAMA psychiatry. - Chicago : American Medical Association (AMA). - 2168-6238 .- 2168-622X. ; 76:5, s. 516-525 Journal article (peer-reviewed)
16.	Stahl, EA, et al. (author) Genome-wide association study identifies 30 loci associated with bipolar disorder 2019 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 51:5, s. 793- Journal article (peer-reviewed)
17.	Locke, Adam E, et al. (author) Genetic studies of body mass index yield new insights for obesity biology. 2015 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401 Journal article (peer-reviewed)abstract Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
18.	Phelan, CM, et al. (author) Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer 2017 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 49:5, s. 680-691 Journal article (peer-reviewed)
19.	Walters, RK, et al. (author) Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders 2018 In: Nature neuroscience. - : Springer Science and Business Media LLC. - 1546-1726 .- 1097-6256. ; 21:12, s. 1656- Journal article (peer-reviewed)
20.	Czamara, D, et al. (author) Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns 2019 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 2548- Journal article (peer-reviewed)abstract Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike’s information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk.

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Result 11-20 of 108

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Type of publication: journal article (106); conference paper (2)

Type of content: peer-reviewed (102); other academic/artistic (6)

Author/Editor: Teumer, A (25); Metspalu, A (23); Esko, T (22); Hayward, C. (22); Uitterlinden, AG (21); Lind, Lars (20); show more...; Gudnason, V (20); Stefansson, K (20); Montgomery, GW (19); Martin, NG (19); Hottenga, JJ (18); Willemsen, G (18); Milaneschi, Y (18); Kutalik, Z. (18); Cichon, S (17); Nothen, MM (17); Rietschel, M (17); Lewis, CM (17); Degenhardt, F (17); Milani, L (17); Pedersen, NL (16); Penninx, BWJH (16); Deary, IJ (16); Lucae, S (16); Schulze, TG (16); Boehnke, M (16); Herms, S. (16); Strohmaier, J (16); Frank, J (16); Treutlein, J (16); MacIntyre, DJ (16); Gordon, SD (16); Jansen, R (15); Sullivan, PF (15); Boomsma, DI (15); Breen, G (15); McIntosh, AM (15); Muller-Myhsok, B (15); Nauck, M (15); Psaty, BM (15); Smoller, JW (15); Medland, SE (15); Levinson, DF (15); Ripke, S (15); Rice, K. (15); Snieder, H. (15); Chasman, Daniel I. (15); van Duijn, Cornelia ... (15); Rotter, Jerome I. (15); Clarke, TK (15); show less...

University: Karolinska Institutet (67); Umeå University (34); Lund University (34); Uppsala University (33); University of Gothenburg (20); Stockholm University (9); show more...; Högskolan Dalarna (5); Luleå University of Technology (3); Linköping University (2); Royal Institute of Technology (1); Örebro University (1); Jönköping University (1); Swedish University of Agricultural Sciences (1); show less...

Language: English (108)

Research subject (UKÄ/SCB): Medical and Health Sciences (67); Natural sciences (16); Engineering and Technology (3); Agricultural Sciences (1); Social Sciences (1)

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