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Träfflista för sökning "WFRF:(Zeleniuch Jacquotte A) srt2:(2005-2009)"

Search: WFRF:(Zeleniuch Jacquotte A) > (2005-2009)

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12.
  • Zeleniuch-Jacquotte, Anne, et al. (author)
  • Circulating enterolactone and risk of endometrial cancer
  • 2006
  • In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 119:10, s. 2376-2381
  • Journal article (peer-reviewed)abstract
    • It has been suggested that phytoestrogens protect against hormone-dependent cancers. Lignans are the main class of phytoestrogens in Western diets. We conducted a prospective study of endometrial cancer and circulating levels of the main human lignan, enterolactone. The design was a case-control study nested within 3 prospective cohort studies, in New York, Sweden and Italy. Serum or plasma samples had been collected at enrollment and stored at -80 degrees C. A total of 153 cases, diagnosed a median of 5.3 years after blood donation, and 271 matched controls were included. No difference in circulating enterolactone was observed between cases (median, 19.2 nmol/L) and controls (18.5 nmol/L). Adjusting for body mass index, the odds ratio for the top tertile of enterolactone, as compared to the lowest was 1.2 (95% CI, 0.7-2.0; p for trend = 0.53). Lack of association was observed in both pre- and postmenopausal women. No correlation was observed between enterolactone and circulating estrogens or SHBG in healthy postmenopausal women. These results do not support a protective role of circulating lignans, in the range of levels observed, against endometrial cancer.
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  • Result 11-12 of 12

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