| 238581. |
- Sarkar, Riddhiman, et al.
(author)
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Proton NMR of (15)N-Choline Metabolites Enhanced by Dynamic Nuclear Polarization.
- 2009
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In: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 1520-5126 .- 0002-7863. ; 131:44, s. 16014-16014
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Journal article (peer-reviewed)abstract
- Chemical shifts of protons can report on metabolic transformations such as the conversion of choline to phosphocholine. To follow such processes in vivo, magnetization can be enhanced by dynamic nuclear polarization (DNP). We have hyperpolarized in this manner nitrogen-15 spins in (15)N-labeled choline up to 3.3% by irradiating the 94 GHz electron spin resonance of admixed TEMPO nitroxide radicals in a magnetic field of 3.35 T during ca. 3 h at 1.2 K. The sample was subsequently transferred to a high-resolution magnet, and the enhanced polarization was converted from (15)N to methyl- and methylene protons, using the small (2,3)J((1)H,(15)N) couplings in choline. The room-temperature lifetime of nitrogen polarization in choline, T(1)((15)N) approximately 200 s, could be considerably increased by partial deuteration of the molecule. This procedure enables studies of choline metabolites in vitro and in vivo using DNP-enhanced proton NMR.
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| 238582. |
- Sarkar, Souvik, et al.
(author)
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Design, synthesis, and evaluation of novel Δ2-thiazolino 2-pyridone derivatives that potentiate isoniazid activity in an isoniazid-resistant mycobacterium tuberculosis mutant
- 2023
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In: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 66:16, s. 11056-11077
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Journal article (peer-reviewed)abstract
- Mycobacterium tuberculosis (Mtb) drug resistance poses an alarming threat to global tuberculosis control. We previously reported that C10, a ring-fused thiazolo-2-pyridone, inhibits Mtb respiration, blocks biofilm formation, and restores the activity of the antibiotic isoniazid (INH) in INH-resistant Mtb isolates. This discovery revealed a new strategy to address INH resistance. Expanding upon this strategy, we identified C10 analogues with improved potency and drug-like properties. By exploring three heterocycle spacers (oxadiazole, 1,2,3-triazole, and isoxazole) on the ring-fused thiazolo-2-pyridone scaffold, we identified two novel isoxazoles, 17h and 17j. 17h and 17j inhibited Mtb respiration and biofilm formation more potently with a broader therapeutic window, were better potentiators of INH-mediated inhibition of an INH-resistant Mtb mutant, and more effectively inhibited intracellular Mtb replication than C10. The (−)17j enantiomer showed further enhanced activity compared to its enantiomer and the 17j racemic mixture. Our potent second-generation C10 analogues offer promise for therapeutic development against drug-resistant Mtb.
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| 238583. |
- Sarkis, Leba M, et al.
(author)
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Bilateral recurrent laryngeal nerve injury in a specialized thyroid surgery unit : would routine intraoperative neuromonitoring alter outcomes?
- 2017
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In: ANZ journal of surgery. - : Wiley. - 1445-1433 .- 1445-2197. ; 87:5, s. 364-367
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Journal article (peer-reviewed)abstract
- BACKGROUND: Bilateral recurrent laryngeal nerve (RLN) palsy following total thyroidectomy is a rare complication, however, poses significant morbidity to the patient when it does occur. The purpose of this paper was to determine the incidence of bilateral RLN palsy in a specialized thyroid unit and determine whether the routine use of intraoperative nerve monitoring (IONM) would alter the outcome.METHODS: This is a retrospective review of prospectively gathered data. A total of 7406 patients underwent total thyroidectomy at the University of Sydney Endocrine Surgical Unit between January 1990 and February 2014. IONM was utilized on a selective basis and we sought to assess whether IONM would have altered outcome in those patients who developed bilateral RLN palsy.RESULTS: Of the 7406 patients who underwent total thyroidectomy, seven patients (0.09%) developed bilateral RLN palsy during the study period. There was one permanent RLN palsy (0.01%) and routine IONM may have prevented one death and altered the outcome in two of the seven patients.CONCLUSION: Bilateral RLN palsy is a rare entity occurring in one out of 1000 cases in a specialized thyroid unit. IONM may facilitate the decision to pursue delayed surgery where the signal is lost on the first surgical side and has the potential to avoid bilateral RLN palsy following total thyroidectomy.
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| 238584. |
- Sarkohi, Ali, 1961-, et al.
(author)
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Avslutande ord
- 2021. - 1
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In: Psykisk ohälsa. - Lund : Studentlitteratur. - 9789144131160 ; , s. 483-484
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Book chapter (other academic/artistic)
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| 238585. |
- Sarkohi, Ali, 1961-, et al.
(author)
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Depression
- 2021
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In: Leva som andra. - Lund : Studentlitteratur AB. - 9789144121437 ; , s. 173-193
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Book chapter (other academic/artistic)
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| 238586. |
- Sarkohi, Ali, 1961-, et al.
(author)
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Depressiva syndrom
- 2021
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In: Psykisk ohälsa. - Lund : Studentlitteratur AB. - 9789144131160 ; , s. 51-78
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Book chapter (other academic/artistic)abstract
- Känslor av sorg, besvikelse och misslyckande är en normal del av vår existens och kan dyka upp i samband med livshändelser som att misslyckas i arbete, utbildning eller relationer, en försämrad ekonomisk situation eller en förlust av en älskad person. Reaktionerna kan yttra sig emotionellt, kognitivt, beteendemässigt och fysiskt. Oftast rör det sig om en tillfällig svacka under några dagar innan personen återgår till ett normalt liv. Men om svackan blir mer intensiv, långvarig och resulterar i försämrad daglig funktionsförmåga med olika negativa konsekvenser kan det röra sig om en depression. I det fallet är det klokt att söka upp sjukvården för att få en eventuell diagnos utredd. Det är viktigt att skilja mellan depressiva symtom som en normal reaktion på en negativ livshändelse och depression som ett medicinskt sjukdomstillstånd. Depression är ett komplext tillstånd där växelverkan mellan biologiska, psykologiska och sociala faktorer påverkar både uppkomst, vidmakthållande och tillfrisknande.
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| 238587. |
- Sarkohi, Ali, 1961-, et al.
(author)
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Inledning
- 2019. - 1
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In: Somatisk sjukdom. - Lund : Studentlitteratur. - 9789144119601 ; , s. 13-34
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Book chapter (other academic/artistic)
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| 238588. |
- Sarkohi, Ali, 1961-, et al.
(author)
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Psykiatrisk suicidprevention under kritik
- 2024
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In: Ögonblick av suicidalitet. - Lund : Studentlitteratur AB. - 9789144131207 ; , s. 47-78
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Book chapter (other academic/artistic)abstract
- Sedan mitten av 1800-talet har psykiatrin haft ett dominerande inflytande på hur man i vård och samhälle ser på suicidalitet och hur man utformat suicidprevention. Det finns goda själ för en positiv värdering av psykiatrins insatser. De tyngsta riskfaktorerna är fortfarande tidigare suicidförsök och psykisk sjukdom. Då handlar det inte om en riskökning på några procent, utan en ökning på 20-40 gånger, det vill säga 2000 till 4000 procent. Tveklöst har psykiatrisk vård förhindrat många suicid samt botat eller lindrat depressions- och ångestsjukdomar hos många patienter. Trots detta har det riktats massiv kritik mot psykiatrisk suicidprevention från suicidala personer, deras närstående, forskare och författare inom psykiatrin samt media, som ofta hävdat att psykiatern helt missuppfattat situationen. Nedan beskrivs i sammanfattade former en del av den kritik som är riktad mot psykiatrins suicidprevention, samt hur psykiatrins suicidprevention har fungerat över tid.
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| 238589. |
- Sarkohi, Ali, et al.
(author)
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Representations of the future in depression. A qualitative study
- 2013
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In: Psychology. - Irvine, CA : Scientific Research Publishing, Inc.. - 2152-7180 .- 2152-7199. ; 4:4, s. 420-426
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Journal article (other academic/artistic)abstract
- Previous studies indicate that the ability to imagine negative and positive future events affect psychological well-being and is a characteristic feature of depression. The aim of this study was to investigate how depressed individuals view their future along different time periods. A total of 15 individuals with a diagnosis of major depression were recruited from a psychiatry clinic and completed a semi-structured qualitative interview. Questions were asked about the situation right now, before becoming depressed, and the future (nearest time, within a year and the upcoming 5-10 years). Data were collected and analysed using open-ended methodology in line with the principles of grounded theory. The results showed that depressed individuals experienced a state of “ambivalence”, with negative cognitive, emotional, physical and socioeconomic consequences, when they were asked to think about their nearest future. Ambivalence and its negative emotional and cognitive effects were substantially reduced in strength when they were asked about their more distant future. We conclude that ambivalence in the present may be an important feature of depression which deserves more attention from both a theoretical and clinical perspective. The use of qualitative approaches in the study of depression is encouraged.
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| 238590. |
- Sarma, S., et al.
(author)
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Association between diabetes mellitus and post-discharge outcomes in patients hospitalized with heart failure: findings from the EVEREST trial
- 2013
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In: European journal of heart failure. - : Wiley. - 1879-0844 .- 1388-9842. ; 15:2, s. 194-202
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Journal article (peer-reviewed)abstract
- AIMS: We evaluated the impact of diabetes mellitus (DM) and diabetic therapy on outcomes in patients with reduced ejection fraction (EF) after hospitalization for heart failure (HF). DM is prevalent in patients hospitalized with HF, yet inconclusive data exist on the post-discharge outcomes of this patient population. METHODS AND RESULTS: Post-hoc analysis was performed on the EVEREST (Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan) study, a randomized trial of patients hospitalized with HF (n = 4133) with median follow-up of 9.9 months. DM status was determined from intake questionnaires and cross-verified by medication history. Univariate relationships were examined using chi(2) test, t-test, and Wilcoxon tests. The two primary outcomes of (i) all-cause mortality (ACM) and (ii) cardiovascular mortality or HF hospitalization (CVM + HFH) were assessed for those with and without DM and by diabetic treatment strategy using log rank tests and multivariable Cox regression models. DM was present in 40% of participants. Patients with DM were more likely to have hypertension, coronary artery disease, and chronic kidney disease. Diabetes was associated with ACM and CVM + HFH (both P < 0.001). Following multivariate risk adjustment, DM was associated with ACM, but this estimate was imprecise [hazard ratio (HR) 1.16; 95% confidence interval (CI) 1.00-1.34] and remained associated with CVM or HFH (HR 1.17; 95% CI 1.04-1.31). Diabetic control strategy did not independently affect outcomes. CONCLUSION: Diabetes is common in patients hospitalized for heart failure with a reduced EF. These patients have a higher post-discharge CVM and higher HF hospitalizations compared with patients with no diabetes. Different diabetic treatment regimens did not appear to influence post-discharge outcomes.
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