| 26. |
- Betsholtz, C, et al.
(author)
-
The glomerular transcriptome and proteome
- 2007
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In: Nephron. Experimental nephrology. - : S. Karger AG. - 1660-2129. ; 106:2, s. E32-E36
-
Journal article (peer-reviewed)abstract
- Histopathology provides the current basis for classification and diagnosis of glomerular disorders. Molecular profiling methods, such as microarray analysis of mRNA expression, have rapidly emerged over the past years and are now applicable to minute amounts of tissue material, such as glomeruli from embryos or adult experimental animals, or from human renal needle biopsies. This review summarizes current efforts aiming at the determination of the glomerular transcriptome and proteome during development, in the healthy adult, and in disease. These studies are encouraging and show that comprehensive molecular profiling of the kidney glomerulus will most likely provide significant new insights into the normal structure and function of the glomerular filter, the molecular mechanisms of glomerular development, the diagnosis and classification of glomerular disease, and the pathogenic mechanisms underlying the stepwise breakdown of glomerular filter function that accompanies several common systemic disorders.
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| 27. |
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| 28. |
- Wu, Harry
(author)
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Genetic parameters and genotype-environment interactions of Chinese fir (Cunninghamia lanceolata) in Fujian Province
- 2014
-
In: Canadian Journal of Forest Research. - : Canadian Science Publishing. - 0045-5067 .- 1208-6037. ; 44, s. 582-592
-
Journal article (peer-reviewed)abstract
- Chinese fir (Cunninghamia lanceolata (Lamb.) Hook) is the most commercially important conifer in China, and the Nanjing Forestry University - Fujian Province Chinese fir Cooperation (NJFU - Fujian Cooperation) breeding program has advanced it into the third cycle of selection and breeding. In this paper, we estimated genetic parameters from four sites for 80 half-sib families and summarized previous estimates of genetic parameters in Chinese fir with an objective to propose optimal breeding strategy. Heritability averaged 0.20 and 0.14 for height and diameter at breast height (DBH), respectively, for the four sites. A significant genotype-environment interaction (G x E) for growth was also observed among the four sites, with the greatest interactions between a marginal site and the three central sites in the Fujian Province Chinese fir plantation region. The average estimated type-B genetic correlation between the marginal site and the three central sites was 0.08 for height and -0.09 for DBH. However, the highly productive families were among the most stable across the four sites. The results from this study in combination with summarized genetic parameters from literature were used to discuss and propose an optimal breeding strategy for the third generation of the breeding program for Chinese firs in Fujian Province.
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| 29. |
- Zahid, Muhammad Awais, et al.
(author)
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A fast, nondestructive method for the detection of disease-related lesions and wounded leaves
- 2021
-
In: Biotechniques. - : Future Science Ltd. - 0736-6205 .- 1940-9818. ; 71
-
Journal article (peer-reviewed)abstract
- Trypan blue staining is a classic way of visualizing leaf disease and wound responses in plants, but it involves working with toxic chemicals and is time-consuming (2-3 days). Here, the investigators established near-infrared scanning with standard lab equipment as a fast and nondestructive method for the analysis of leaf injuries compared with trypan blue staining. Pathogen-inoculated and wounded leaves from potato, tomato, spinach, strawberry, and arabidopsis plants were used for proof of concept. The results showed that this newly developed protocol with near-infrared scanning gave the same results as trypan blue staining. Furthermore, a macro in FIJI was made to quantify the leaf damage. The new protocol was time-efficient, nondestructive, chemical-free and may be used for high-throughput studies.
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| 30. |
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| 31. |
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| 32. |
- Afghahi, Henri, 1966, et al.
(author)
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Risk factors for the development of albuminuria and renal impairment in type 2 diabetes—the Swedish National Diabetes Register (NDR)
- 2010
-
In: Nephrology, Dialysis and Transplantation. - : Oxford University Press (OUP). - 0931-0509 .- 1460-2385. ; 26:4, s. 1236-1243
-
Journal article (peer-reviewed)abstract
- Background. The aim of this study was to identify clinical risk factors associated with the development of albuminuria and renal impairment in patients with type 2 diabetes (T2D). In addition, we evaluated if different equations to estimate renal function had an impact on interpretation of data. This was done in a nationwide population-based study using data from the Swedish National Diabetes Register. Methods. Three thousand and six hundred sixty-seven patients with T2D aged 30-74 years with no signs of renal dysfunction at baseline (no albuminuria and eGFR >60 mL/min/1.73 m(2) according to MDRD) were followed up for 5 years (2002-2007). Renal outcomes, development of albuminuria and/or renal impairment [eGFR < 60 mL/min/1.73 m(2) by MDRD or eCrCl > 60 mL/min by Cockgroft-Gault (C-G)] were assessed at follow-up. Univariate regression analyses and stepwise regression models were used to identify significant clinical risk factors for renal outcomes. Results. Twenty percent of patients developed albuminuria, and 11% renal impairment; thus, ~6-7% of all patients developed non-albuminuric renal impairment. Development of albuminuria or renal impairment was independently associated with high age (all P < 0.001), high systolic BP (all P < 0.02) and elevated triglycerides (all P < 0.02). Additional independent risk factors for albuminuria were high BMI (P < 0.01), high HbA1c (P < 0.001), smoking (P < 0.001), HDL (P < 0.05) and male sex (P < 0.001), and for renal impairment elevated plasma creatinine at baseline and female sex (both P < 0.001). High BMI was an independent risk factor for renal impairment when defined by MDRD (P < 0.01), but low BMI was when defined by C-G (P < 0.001). Adverse effects of BMI on HbA1c, blood pressure and lipids accounted for ~50% of the increase risk for albuminuria, and for 41% of the increased risk for renal impairment (MDRD). Conclusions. Distinct sets of risk factors were associated with the development of albuminuria and renal impairment consistent with the concept that they are not entirely linked in patients with type 2 diabetes. Obesity and serum triglycerides are semi-novel risk factors for development of renal dysfunction and BMI accounted for a substantial proportion of the increased risk. The equations used to estimate renal function (MDRD vs. C-G) had an impact on interpretation of data, especially with regard to body composition and gender.
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| 33. |
- Afif, A., et al.
(author)
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Ceramic fuel cells using novel proton-conducting BaCe 0.5 Zr 0.3 Y 0.1 Yb 0.05 Zn 0.05 O 3-δ electrolyte
- 2022
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In: Journal of Solid State Electrochemistry. - : Springer Science and Business Media LLC. - 1433-0768 .- 1432-8488. ; 1:26, s. 111-120
-
Journal article (peer-reviewed)abstract
- Protonic ceramic fuel cells have become extremely interesting due to their high power output at the intermediate temperature range (400–700 °C). Significant progress has been made to develop electrolyte materials, doped barium cerates-zirconate, which gets the leading role due to its high chemical stability and high ionic conductivity. Here, we present a new composition BaCe0.5Zr0.3Y0.1Yb0.05Zn0.05O3-δ (BCZYYbZn05), where addition of 5 mol% Zn with Ce, Zr, Y, and Yb at the B-site of the perovskite material shows high stability with high conductivity. The material was synthesized by solid-state reaction route at 1400 °C which showed 98% relative density. Rietveld analysis of neutron powder diffraction data reveal an orthorhombic structure with Pbnm space group. Thermogravimetric analysis shows about 1.06% weight loss from 200 to 1000 °C which is mainly related to the formation of the oxygen vacancies. In wet hydrogen atmosphere, this material shows higher conductivity and lower activation energy than dry hydrogen atmosphere indicates the conduction type as protonic conduction. The anode-supported single test cell based on this electrolyte material demonstrates peak power densities 649 mW cm−2 at 700 °C using conventional BSCF cathode, representing an important step toward commercially viable SOFC technology.
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| 34. |
- Afif, A., et al.
(author)
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Electrochemical and structural characterization of BaCe 0.7 Zr 0.15 Y 0.1 Zn 0.05 O 3-δ as an electrolyte for SOFC-H
- 2018
-
In: IET Conference Publications. ; 2018:CP750
-
Conference paper (peer-reviewed)abstract
- As a potential electrolyte for proton-conducting solid oxide fuel cells (SOFC-Hs) and to get better protonic conductivity and stability, zinc doped BCZY material has been found to be promising. In this study, we report a new composition of proton conductors BaCe0.7Zr0.15Y01Zn0.05O3-s (BCZYZn10) which was investigated using XRD, SEM and conductivity measurements. Rietveld refinement of the XRD data revel a cubic perovskite structure with Pm-3m space group. Rietveld analysis of BaCe07Zr0.15Y01Zn0.05O3-5 shows the unit cell parameter is a = 4.3582(7) A. Scanning electron microscopy images shows that the grain sizes are large and compact which gives the sample high density and good protonic conductivity. The total conductivity in wet atmosphere is significantly higher than that of dry condition and the conductivity was found to be 0.004032 Scm-1 and 0.00164 Scm-1 at 600 °C in wet and dry Ar, respectively. This study indicated that perovskite electrolyte BCZYZn10 is a promising material for the next generation intermediate temperature solid oxide fuel cells (IT-SOFCs).
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| 35. |
- Ayyer, Arvind, et al.
(author)
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An inhomogeneous multispecies TASEP on a ring
- 2014
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In: Advances in Applied Mathematics. - : Elsevier BV. - 0196-8858 .- 1090-2074. ; 57, s. 21-43
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Journal article (peer-reviewed)abstract
- We reinterpret and generalize conjectures of Lam and Williams as statements about the stationary distribution of a multispecies exclusion process on the ring. The central objects in our study are the multiline queues of Ferrari and Martin. We make some progress on some of the conjectures in different directions. First, we prove Lam and Williams' conjectures in two special cases by generalizing the rates of the Ferrari-Martin transitions. Secondly, we define a new process on multiline queues, which have a certain minimality property. This gives another proof for one of the special cases; namely arbitrary jump rates for three species.
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| 36. |
- Ayyer, Arvind, et al.
(author)
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Correlations in the multispecies tasep and a conjecture by Lam
- 2017
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In: Transactions of the American Mathematical Society. - : American Mathematical Society (AMS). - 0002-9947 .- 1088-6850. ; 369:2, s. 1097-1125
-
Journal article (peer-reviewed)abstract
- We study correlations in the multispecies TASEP on a ring. Results on the correlation of two adjacent points prove two conjectures by Thomas Lam on (a) the limiting direction of a reduced random walk in (A) over tilde (n-1) and (b) the asymptotic shape of a random integer partition with no hooks of length n, a so called n-core. We further investigate two-point correlations far apart and three-point nearest neighbour correlations and prove explicit formulas in almost all cases. These results can be seen as a finite strengthening of correlations in the TASEP speed process by Amir, Angel and Valko. We also give conjectures for certain higher order nearest neighbour correlations. We find an unexplained independence property (provably for two points, conjecturally for more points) between points that are closer in position than in value that deserves more study.
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| 37. |
- Ayyer, Arvind, et al.
(author)
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Some generalized juggling processes (extended abstract)
- 2015
-
In: DMTCS proc. FPSAC'15. - Nancy, France. ; , s. 925-936
-
Conference paper (peer-reviewed)abstract
- We consider generalizations of juggling Markov chains introduced by Ayyer, Bouttier, Corteel and Nunzi. We first study multispecies generalizations of all the finite models therein, namely the MJMC, the add-drop and the annihilation models. We then consider the case of several jugglers exchanging balls. In all cases, we give explicit product formulas for the stationary probability and closed-form expressions for the normalization factor if known.
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| 38. |
- Crawford, G. C., et al.
(author)
-
Power law distributions in entrepreneurship : Implications for theory and research
- 2015
-
In: Journal of Business Venturing. - : Elsevier Inc.. - 0883-9026 .- 1873-2003. ; 30:5, s. 696-713
-
Journal article (peer-reviewed)abstract
- A long-held assumption in entrepreneurship research is that normal (i.e., Gaussian) distributions characterize variables of interest for both theory and practice. We challenge this assumption by examining more than 12,000 nascent, young, and hyper-growth firms. Results reveal that variables which play central roles in resource-, cognition-, action-, and environment-based entrepreneurship theories exhibit highly skewed power law distributions, where a few outliers account for a disproportionate amount of the distribution's total output. Our results call for the development of new theory to explain and predict the mechanisms that generate these distributions and the outliers therein. We offer a research agenda, including a description of non-traditional methodological approaches, to answer this call.
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| 39. |
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| 40. |
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| 41. |
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| 42. |
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| 43. |
- Zahid, Muhammad Awais
(author)
-
Insights into potato plant immunity reveals Parakletos as a novel ROS suppressor
- 2022
-
Doctoral thesis (other academic/artistic)abstract
- Potato (Solanum tuberosum L.) is the world's third most commonly grown food crop with very high yield potential. However, its production is hampered by several pathogens, with consequent yield losses. Existing control methods include frequent, costly fungicide applications, and classical breeding is complicated in potato. One way to develop new longterm solutions is to improve understanding of plant molecular immunity and factors capable of providing broad-spectrum resistance. To assist such efforts, comparative proteomic techniques were applied to enhance understanding of changes in protein abundance during the immune responses of potato. These focused on a PTI (Pattern-triggered immunity) model and two ETI (Effector-triggered immunity) models (both related to resistance genes to Phytophthora infestans, the causal agent of late blight) in potato to enhance understanding of changes in protein abundance during its immune responses. Numerous proteins increased in abundance in all observed immune responses, including one identified as sterol transporter protein 2, which is intriguing because sterol content plays an important role in plant immunity, and oomycete pathogens like P. infestans rely on their hosts for sterols. The abundance of RNA binding proteins also changed in different immune reactions. A few proteins changed in abundance in only one of the ETI models, e.g., histones were downregulated in one (ETI responses to P. infestans effector Avr2), whereas a putative multiprotein bridging factor was upregulated in the other (ETI responses to P. infestans effector IpiO). Intriguingly, the proteomic differences between the two ETI models were of similar magnitude to those between the ETI models and PTI. The next step was to study the general PTI-related defence potato proteome by two-step fractionation and new bioinformatics analyses. Five candidates with potential importance in our proteomic dataset were selected for functional validation studies. To facilitate validation studies, a luminol-based assay was developed to study biphasic reactive oxygen species (ROS) bursts in potato leaves induced by flg22 and P. infestans as well as an easy, cost-effective method using near-IR scanning to quantify leaf wounding and disease lesion areas without damaging leaves. Over-expression and silencing of one identified protein, named Parakletos, respectively increased and reduced P. infestans infection in Nicotiana benthamiana. Moreover, its overexpression suppressed the ROS burst response to flg22, while its silencing increased it. Transcript analyses showed upregulation of defence-related genes (e.g., ICS1, PR1, PTI5, and RBOHB) in response to flg22 in Parakletos-silenced plants. Expression of light-harvesting complex B6 (LHCB6) was also enhanced in plants overexpressing Parakletos. It was found that Parakletos co-localized with the Calcium Sensing Receptor (CAS) in chloroplasts, and that it is functionally dependent on CAS. Furthermore, CRISPR/Cas9-mediated knock-out (KO) of parakletos in potato enhanced broad-spectrum resistance to late and early blight in controlled condition. It also reduced infection to Pseudomonas syringae in N. benthamiana. Moreover, during field trials the parakletos-KO lines showed enhanced resistance to P. infestans. These findings contribute to our understanding of plant immunity and provide a new susceptibility-gene based strategy for building broad-spectrum disease resistance in crops.
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| 44. |
- Zahid, Maryam
(author)
-
Model-Based Trust Assessment in Autonomous Cyber-Physical Production Systems
- 2024
-
Licentiate thesis (other academic/artistic)abstract
- An increase in consumer demand and scarcity of available resources has led industrialists to hunt for solutions related to the automation of traditional manufacturing and production processes, optimizing resource consumption while improving the overall efficiency of the process. The resultant revolution brought forward the concept of cyber-physical production systems. Furthermore, industries within the private sector have integrated artificial intelligence with their traditional production processes as Cobots (collaborative robots), thus introducing the concept of Autonomous Cyber-Physical Production Systems. Although these systems maximize the production or manufacturing process while efficiently using the available resources, the machine learning component integrated into the traditional cyber-physical production system brings about trust-related issues due to its possible lack of predictability and transparency. Implementing trust-related attributes within autonomous cyber-physical production systems alone cannot overcome the highlighted problem. Therefore, a detailed risk assessment is required to identify and assess any trust-related risks in the system, especially at the early stages of the software development life cycle, to avoid major incidents and reduce maintenance costs. Based on the above-stated facts, this research proposes a model-based risk assessment technique for evaluating the trustworthiness of autonomous cyber-physical production systems. The proposed technique focuses on the identification and assessment of trust-related risks originating from the dynamic behavior of the machine learning component in autonomous cyber-physical production systems. For this, we use existing standards and techniques proposed for risk assessment in cyber-physical production systems as common ground to facilitate better implementation of trustworthiness in autonomous cyber-physical production systems. The proposed technique is aimed at overcoming the structural and behavioral limitations reported in existing model-based risk assessment techniques when dealing with autonomous cyber-physical production systems.
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| 45. |
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| 46. |
- Afghahi, Henri, 1966, et al.
(author)
-
The association between long-term glycemic control and all-cause mortality is different among older versus younger patients with diabetes mellitus and maintenance hemodialysis treatment.
- 2022
-
In: Diabetes research and clinical practice. - : Elsevier BV. - 1872-8227 .- 0168-8227. ; 191
-
Journal article (peer-reviewed)abstract
- Knowledge about association between glycated hemoglobin (HbA1c) and risk of all-cause mortality in patients with diabetes mellitus on maintenance hemodialysis (HD)-treatment is sparse. The study aims to investigate association between HbA1c and all-cause mortality in patients with diabetes and maintenance HD-treatment, separately for two age groups- above and below 75years.2487 patients (mean age 66years, 66% men) were separated in two age groups: ≤75years (n=1810) and>75years (n=677) and followed up between 2008 and 2018. Hazard ratios (HR) and 95% confidence intervals (CI) for associations between HbA1c and all-cause mortality were calculated using Cox-regression-models.1295 (52%) patients died and 473 (70%) among the patients above 75years old. In the multivariate analysis, HbA1c5-6% was used as reference. In patients≤75years old, only increased HbA1c>9.7%, HR2.03(CI1.43-2.89) was associated with increased risk of all-cause mortality. In patients>75years, HbA1c≤5%, HR1.67(CI1.16-2.40); HbA1c6.9-7.8%, HR1.41(CI1.03-1.93) and HbA1c8.7-9.7%, HR1.79 (CI1.08-2.96) were associated with increased risk of all-cause mortality.We found a J-shaped association between HbA1c and mortality only in diabetic HD-patients>75years. This probably indicates that in an old population of diabetic HD-patients, both intensive glucose control and hyperglycemia could be harmful and associated with higher risk of death.
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| 47. |
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| 48. |
- Afif, A., et al.
(author)
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Advanced materials and technologies for hybrid supercapacitors for energy storage – A review
- 2019
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In: Journal of Energy Storage. - : Elsevier BV. - 2352-152X. ; 25:October 2019
-
Research review (peer-reviewed)abstract
- Supercapacitors have become the most significant energy conversion and storage system in recent renewable and sustainable nanotechnology. Due to its large energy capacity and supply with relatively short time and longer lifetime, supercapacitors breakthrough in advance energy applications. This review presents a comparative study of different materials, working principles, analysis, applications, advantages and disadvantages of various technologies available for supercapacitors. The aim of this article is to discuss the possibility of hybrid supercapacitor for the next generation of energy technology. The development of composite materials containing a wide range of active constituents (e.g., graphene, activated carbon, transition metals, metal oxides, perovskites and conducting polymers) by in-situ hybridization and ex-situ recombination is also discussed. This review consecrated largely the contribution of combining all materials (electrode and electrolyte) and their synthesis process and electrochemical performance. Enduringly, the potential issues and the perspectives for future research based on hybrid supercapacitors in energy applications are also presented.
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| 49. |
- Asadi, Shahla, et al.
(author)
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Determinants of Intention to Use Simulation-Based Learning in Computers and Networking Courses : An ISM and MICMAC Analysis
- 2024
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In: IEEE transactions on engineering management. - : IEEE. - 0018-9391 .- 1558-0040. ; 71, s. 6015-6030
-
Journal article (peer-reviewed)abstract
- Simulation-based learning (SBL) presents a wide variety of opportunities to practice complex computer and networking skills in higher education, employing various platforms to enhance educational outcomes. The integration of SBL tools in teaching computer networking courses is useful for both instructors and learners. Furthermore, the increasing importance of SBL in higher education highlights the necessity to further explore the factors that affect the adoption of SBL technologies, particularly in the field of computer networking courses. Despite these advantages, minimal effort has been made to examine the factors that impact instructors' intentions to use SBL tools for computers and networking courses. The main objective of this study is to examine the factors that affect instructors' intentions to utilize SBL tools in computer networking courses offered by higher education institutions. By employing Interpretive structural modeling (ISM) and Matriced' Impacts Croise's Multiplication Appliquee a UN Classement (MICMAC) analysis, the research attempts to provide an in-depth understanding of the interdependencies and hierarchical associations among twelve identified factors. Results showed that system quality, self-efficacy, technological knowledge, and information quality have high driving power. This study offers valuable perspectives for higher education institutions and for upcoming empirical studies and aids in comprehending the advantages of using SBL tools in teaching and higher education.
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| 50. |
- Ayyer, A., et al.
(author)
-
Bumping sequences and multispecies juggling
- 2018
-
In: Advances in Applied Mathematics. - : Academic Press. - 0196-8858 .- 1090-2074. ; 98, s. 100-126
-
Journal article (peer-reviewed)abstract
- Building on previous work by four of us (ABCN), we consider further generalizations of Warrington's juggling Markov chains. We first introduce “multispecies” juggling, which consist in having balls of different weights: when a ball is thrown it can possibly bump into a lighter ball that is then sent to a higher position, where it can in turn bump an even lighter ball, etc. We both study the case where the number of balls of each species is conserved and the case where the juggler sends back a ball of the species of its choice. In this latter case, we actually discuss three models: add-drop, annihilation and overwriting. The first two are generalisations of models presented in (ABCN) while the third one is new and its Markov chain has the ultra fast convergence property. We finally consider the case of several jugglers exchanging balls. In all models, we give explicit product formulas for the stationary probability and closed form expressions for the normalisation factor if known.
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