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26.	Shahrara, S, et al. (author) Organ specific expression of thyroid hormone receptor mRNA and protein in different human tissues 1999 In: Biological & pharmaceutical bulletin. - : Pharmaceutical Society of Japan. - 0918-6158 .- 1347-5215. ; 22:10, s. 1027-1033 Journal article (peer-reviewed)
27.	Shahrara, S, et al. (author) Subtype specific downregulation of thyroid hormone receptor mRNA by beta-adrenoreceptor blockade in the myocardium 2000 In: Biological & pharmaceutical bulletin. - : Pharmaceutical Society of Japan. - 0918-6158 .- 1347-5215. ; 23:11, s. 1303-1306 Journal article (peer-reviewed)
28.	Shahrara, S, et al. (author) Thyroid hormone alpha1 and beta1 receptor mRNA are downregulated by amiodarone in mouse myocardium 1999 In: Journal of cardiovascular pharmacology. - : Ovid Technologies (Wolters Kluwer Health). - 0160-2446. ; 34:2, s. 261-267 Journal article (peer-reviewed)
29.	Shahrara, S, et al. (author) Upregulation of thyroid hormone receptor beta 1 and beta 2 messenger RNA in the myocardium of dogs with dilated cardiomyopathy or chronic valvular disease 1999 In: American journal of veterinary research. - 0002-9645. ; 60:7, s. 848-852 Journal article (peer-reviewed)
30.	Siddiqui, A, et al. (author) Antagonism of the renin angiotensin system counteracts cardiac angiogenic VEGF gene therapy 2002 In: EUROPEAN HEART JOURNAL. - 0195-668X. ; 23, s. 381-381 Conference paper (other academic/artistic)
31.	Sylven, C, et al. (author) Catheter-based transcutaneous transendocardial myocardial gene transfer 2001 In: CIRCULATION. - 0009-7322. ; 104:17, s. 664-664 Conference paper (other academic/artistic)
32.	Sylvén, C, et al. (author) Catheter-based transendocardial myocardial gene transfer 2002 In: Journal of interventional cardiology. - : Wiley. - 0896-4327 .- 1540-8183. ; 15:1, s. 7-13 Journal article (peer-reviewed)
33.	Sylven, C, et al. (author) Dose-response transfection and vascular effects of vascular endothelial growth factor165 (phVEGF165) in normoxic and hypoxic rat myocardium 2001 In: EUROPEAN HEART JOURNAL. - 0195-668X. ; 22, s. 428-428 Conference paper (other academic/artistic)
34.	Sylven, C., et al. (author) Myocardial Doppler tissue velocity improves following myocardial gene therapy with VEGF-A(165) plasmid in patients with inoperable angina pectoris 2001 In: Coronary Artery Disease. - : Ovid Technologies (Wolters Kluwer Health). - 0954-6928 .- 1473-5830. ; 12:3, s. 239-243 Journal article (peer-reviewed)abstract Background Myocardial tissue velocity and perfusion were studied in patients with severe angina pectoris following gene therapy by intramyocardial injection of phVEGF-A(165) via thoracotomy. Plasma concentrations of VEGF-A increased postoperatively. Two months after treatment anginal status and myocardial tissue velocity improved and perfusion showed a tendency to improve. Tissue velocity imaging appears to be a sensitive, objective method for detecting changes in myocardial function following gene therapy. Objective To study effects on myocardial tissue velocity and perfusion in patients with angina pectoris following intramyocardial injection of phVEGF-A(165) via thoracotomy. Design Open label, phase I/II. Methods Six patients with Canadian Cardiovascular Society (CCS) angina pectoris functional Glass III - IV and with major defects at adenosine stress single-photon emission computerized tomography (SPECT) were studied. In addition to SPECT, coronary angiography and dobutamine stress echocardiography with tissue Doppler velocity imaging were performed before and two months after gene transfer. Results Plasma concentrations of VEGF-A increased 2 to 3 times (P < 0.04) over baseline from 2 to 14 days after injection with normalization after 4 weeks. The CCS class improved about 40%, from 3.3 +/- 0.2 to 2.0 +/- 0.3 (P < 0.02) and nitroglycerine consumption decreased 30 - 40%, from 44 +/- 17 to 15 +/- 5 tablets per week (P < 0.05). The maximal systolic myocardial tissue velocity increased in all patients about 25% (P < 0.02) but did not reach the reference range. Myocardial perfusion at SPECT improved in four of the six patients. Conclusions Anginal status, myocardial tissue velocity and perfusion can be improved by phVEGF-A(165) intramyocardial injection. Tissue velocity imaging appears to be a sensitive, objective method for detecting changes in myocardial function following gene therapy. Coron Artery Dis 12:239-243
35.	Sylven, C, et al. (author) Protein and angiogenic dose-response expression of phVEGF-A(165) gene in rat myocardium 2001 In: Journal of thrombosis and thrombolysis. - 0929-5305. ; 12:2, s. 151-156 Journal article (peer-reviewed)
36.	Sylven, C, et al. (author) Vascular endothelial growth factor (VEGF-A165) gene therapy improves myocardial function in patients with refractory angina pectoris due to coronary artery disease 2001 In: EUROPEAN HEART JOURNAL. - 0195-668X. ; 22, s. 623- Conference paper (other academic/artistic)

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Result 26-36 of 36

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Type of publication: journal article (25); conference paper (11)

Type of content: peer-reviewed (24); other academic/artistic (12)

Author/Editor: Drvota, V (36); Sylven, C (28); Ruck, A (10); Sarkar, N (9); Blomberg, P (9); Blange, I (5); show more...; Kallner, G (5); Islam, K. (5); Wardell, E (5); Lind, B (4); Lindblom, D (4); Nygren, A (3); Bronnegard, M (3); Dudek, D (3); Ruzyllo, W (3); Soderberg, M (2); Carlsson, B (2); Eggertsen, G (2); Friberg, L. (2); Gustafsson, T. (2); Ahnve, S (2); Insulander, P (2); van der Linden, J (2); Norrbom, J (2); Brodin, LA (2); Brodin, Lars-Åke (2); Islam, KB (2); Y-Hassan, S (2); Jamsa, A (2); Fischer, H. (1); Nowak, J. (1); Janson, A (1); Ringden, O (1); Marcus, C (1); Le Blanc, K (1); Kenneback, G (1); Kennebäck, G (1); Grinnemo, KH (1); Holgersson, J (1); Wei, H. (1); Sundberg, CJ (1); Dellgren, G. (1); Barkhem, T (1); Eskandarpour, M (1); Yen, PM (1); Buch, HK (1); Gustafsson, AC (1); Mansson, A (1); Magnusson, Yvonne, 1 ... (1); Norman, C (1); show less...

University: Karolinska Institutet (36); Royal Institute of Technology (2); University of Gothenburg (1)

Language: English (36)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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