SwePub - search: L773:1869 408X OR L773:1869 40...

Enumeration	Reference	Cover	Find
1.	Gallo, C, et al. (author) Testing a Patient-Specific In-Silico Model to Noninvasively Estimate Central Blood Pressure 2021 In: Cardiovascular engineering and technology. - : Springer Science and Business Media LLC. - 1869-4098 .- 1869-408X. ; 12:2, s. 144-157 Journal article (peer-reviewed)
2.	Wahlquist, Ylva, et al. (author) Prevention of ischemic myocardial contracture through hemodynamically controlled DCD 2021 In: Cardiovascular Engineering and Technology. - : Springer Science and Business Media LLC. - 1869-408X .- 1869-4098. ; 12:5, s. 485-493 Journal article (peer-reviewed)abstract Purpose—Ischemic myocardial contracture (IMC) or ‘‘stoneheart’’ is a condition with rapid onset following circulatory death. It inhibits transplantability of hearts donated uponcirculatory death (DCD). We investigate the effectiveness of hemodynamic normalization upon withdrawal of life-sustaining therapy (WLST) in a large-animal controlled DCD model, with the hypothesis that reduction in cardiac work delays the onset of IMC. Methods—A large-animal study was conducted comprising of a control group (n = 6) receiving no therapy upon WLST, and a test group (n = 6) subjected to a protocol for fully automated computer-controlled hemodynamic drug administration. Onset of IMC within 1 h following circulatory death defined the primary end-point. Cardiac work estimates based on pressure-volume loop concepts were developed and used to provide insight into the effectiveness of the proposed computer-controlled therapy. Results—No test group individual developed IMC within 1 h, whereas all control group individuals did (4/6 within30 min). Conclusion—Automatic dosing of hemodynamic drugs in the controlled DCD context has the potential to prevent onset of IMC up to 1 h, enabling ethical and medically safe organ procurement. This has the potential to increase the use of DCD heart transplantation, which has been widely recognized as a means of meeting the growing demand for donor hearts.

Wahlquist, Ylva, et al. (author)
Prevention of ischemic myocardial contracture through hemodynamically controlled DCD
2021
In: Cardiovascular Engineering and Technology. - : Springer Science and Business Media LLC. - 1869-408X .- 1869-4098. ; 12:5, s. 485-493
Journal article (peer-reviewed)abstract
- Purpose—Ischemic myocardial contracture (IMC) or ‘‘stoneheart’’ is a condition with rapid onset following circulatory death. It inhibits transplantability of hearts donated uponcirculatory death (DCD). We investigate the effectiveness of hemodynamic normalization upon withdrawal of life-sustaining therapy (WLST) in a large-animal controlled DCD model, with the hypothesis that reduction in cardiac work delays the onset of IMC. Methods—A large-animal study was conducted comprising of a control group (n = 6) receiving no therapy upon WLST, and a test group (n = 6) subjected to a protocol for fully automated computer-controlled hemodynamic drug administration. Onset of IMC within 1 h following circulatory death defined the primary end-point. Cardiac work estimates based on pressure-volume loop concepts were developed and used to provide insight into the effectiveness of the proposed computer-controlled therapy. Results—No test group individual developed IMC within 1 h, whereas all control group individuals did (4/6 within30 min). Conclusion—Automatic dosing of hemodynamic drugs in the controlled DCD context has the potential to prevent onset of IMC up to 1 h, enabling ethical and medically safe organ procurement. This has the potential to increase the use of DCD heart transplantation, which has been widely recognized as a means of meeting the growing demand for donor hearts.

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