↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Angulo R) srt2:(2015-2019)"

Search: WFRF:(Angulo R) > (2015-2019)

Result 1-3 of 3

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Goetghebuer, T, et al. (author) Time to Switch to Second-line Antiretroviral Therapy in Children With Human Immunodeficiency Virus in Europe and Thailand 2018 In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. - : Oxford University Press (OUP). - 1537-6591. ; 66:4, s. 594-603 Journal article (peer-reviewed)
2.	Crichton, S, et al. (author) Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand 2019 In: AIDS (London, England). - 1473-5571. ; 33:12, s. 1897-1910 Journal article (peer-reviewed)
3.	Moreno, Noelia, et al. (author) Rabbit hemorrhagic disease virus capsid, a versatile platform for foreign B-cell epitope display inducing protective humoral immune responses 2016 In: Scientific Reports. - : NATURE PUBLISHING GROUP. - 2045-2322. ; 6:31844 Journal article (peer-reviewed)abstract Virus-like particles (VLPs), comprised of viral structural proteins devoid of genetic material, are tunable nanoparticles that can be chemically or genetically engineered, to be used as platforms for multimeric display of foreign antigens. Here, we report the engineering of chimeric VLPs, derived from rabbit hemorrhagic disease virus (RHDV) for presentation of foreign B-cell antigens to the immune system. The RHDV capsid comprises 180 copies of a single capsid subunit (VP60). To evaluate the ability of chimeric RHDV VLPs to elicit protective humoral responses against foreign antigens, we tested two B-cell epitopes: a novel neutralizing B-cell epitope, derived from feline calicivirus capsid protein, and a well characterized B-cell epitope from the extracellular domain of influenza A virus M2 protein (M2e). We generated sets of chimeric RHDV VLPs by insertion of the foreign B-cell epitopes at three different locations within VP60 protein (which involved different levels of surface accessibility) and in different copy numbers per site. The immunogenic potential of the chimeric VLPs was analyzed in the mouse model. The results presented here indicated that chimeric RHDV VLPs elicit potent protective humoral responses against displayed foreign B-cell epitopes, demonstrated by both, in vitro neutralization and in vivo protection against a lethal challenge.

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-3 of 3

Refine your search

Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Giacomet, V (2); Maccabruni, A (2); Mur, A (2); Marczynska, M (2); Wyler, CA (2); Rudin, C (2); show more...; Duppenthaler, A (2); Moreno, D. (2); Schmid, P. (2); Perez, C. (2); Weber, R. (2); Alvarez, C. (2); Pantaleo, G (2); Freeman, A (2); Evans, J. (2); Boucher, CAB (2); Romano, A (2); Eisenhut, M (2); Gibb, DM (2); Harper, L (2); Butler, K (2); Mazza, A (2); Cellini, M (2); Lyall, H (2); Sharland, M (2); Sloper, K (2); Reiss, P (2); Hoffmann, M. (2); Mendez, M (2); van Rossum, AMC (2); Garzon, M (2); Saavedra, J (2); Battegay, M (2); Bernasconi, E (2); Hosli, I (2); Vernazza, P (2); Hainaut, M (2); Fortuny, C (2); Aebi-Popp, K (2); de Tejada, BM (2); Fehr, J (2); Grawe, C (2); Perez, A. (2); Martínez, J. (2); Jones, L (2); Bustillo, M (2); Berkhout, B (2); Trkola, A (2); Alvarez, S (2); Hancock, J (2); show less...

University: Karolinska Institutet (2); Linköping University (1)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view