1. |
- Benseguane, Selma, et al.
(author)
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Evolution of pits at the surface of 67P/Churyumov-Gerasimenko
- 2022
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 668
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Journal article (peer-reviewed)abstract
- Context. The observation of pits at the surface of comets offers the opportunity to take a glimpse into the properties and the mechanisms that shape a nucleus through cometary activity. If the origin of these pits is still a matter of debate, multiple studies have recently suggested that known phase transitions (such as volatile sublimation or amorphous water ice crystallization) alone could not have carved these morphological features on the surface of 67P/Churyumov-Gerasimenko (hereafter 67P).Aims. We want to understand how the progressive modification of 67P' s surface due to cometary activity might have affected the characteristics of pits and alcoves. In particular, we aim to understand whether signatures of the formation mechanism of these surface morphological features can still be identified.Methods. To quantify the amount of erosion sustained at the surface of 67P since it arrived on its currently observed orbit, we selected 380 facets of a medium-resolution shape model of the nucleus, sampling 30 pits and alcoves across the surface. We computed the surface energy balance with a high temporal resolution, including shadowing and self-heating contributions. We then applied a thermal evolution model to assess the amount of erosion sustained after ten orbital revolutions under current illumination conditions.Results. We find that the maximum erosion sustained after ten orbital revolutions is on the order of 80 m, for facets located in the southern hemisphere. We thus confirm that progressive erosion cannot form pits and alcoves, as local erosion is much lower than their observed depth and diameter. We find that plateaus tend to erode more than bottoms, especially for the deepest depressions, and that some differential erosion can affect their morphology. As a general rule, our results suggest that sharp morphological features tend to be erased by progressive erosion.Conclusions. This study supports the assumption that deep circular pits, such as Seth_01, are the least processed morphological features at the surface of 67P, or the best preserved since their formation.
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2. |
- Galluzzi, Lorenzo, et al.
(author)
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Prognostic Impact of Vitamin B6 Metabolism in Lung Cancer
- 2012
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In: Cell Reports. - Cambridge : Cell press. - 2211-1247. ; 2:2, s. 257-269
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Journal article (peer-reviewed)abstract
- Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism as a central regulator of cisplatin responses in vitro and in vivo. By aggravating a bioenergetic catastrophe that involves the depletion of intracellular glutathione, vitamin B6 exacerbates cisplatin-mediated DNA damage, thus sensitizing a large panel of cancer cell lines to apoptosis. Moreover, vitamin B6 sensitizes cancer cells to apoptosis induction by distinct types of physical and chemical stress, including multiple chemotherapeutics. This effect requires pyridoxal kinase (PDXK), the enzyme that generates the bioactive form of vitamin B6. In line with a general role of vitamin B6 in stress responses, low PDXK expression levels were found to be associated with poor disease outcome in two independent cohorts of patients with NSCLC. These results indicate that PDXK expression levels constitute a biomarker for risk stratification among patients with NSCLC.
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3. |
- Massironi, Matteo, et al.
(author)
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Two independent and primitive envelopes of the bilobate nucleus of comet 67P
- 2015
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 526:7573, s. 402-405
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Journal article (peer-reviewed)abstract
- The factors shaping cometary nuclei are still largely unknown, but could be the result of concurrent effects of evolutionary(1,2) and primordial processes(3,4). The peculiar bilobed shape of comet 67P/Churyumov-Gerasimenko may be the result of the fusion of two objects that were once separate or the result of a localized excavation by outgassing at the interface between the two lobes(5). Here we report that the comet's major lobe is enveloped by a nearly continuous set of strata, up to 650 metres thick, which are independent of an analogous stratified envelope on the minor lobe. Gravity vectors computed for the two lobes separately are closer to perpendicular to the strata than those calculated for the entire nucleus and adjacent to the neck separating the two lobes. Therefore comet 67P/Churyumov-Gerasimenko is an accreted body of two distinct objects with 'onion-like' stratification, which formed before they merged. We conclude that gentle, low-velocity collisions occurred between two fully formed kilometre-sized cometesimals in the early stages of the Solar System. The notable structural similarities between the two lobes of comet 67P/Churyumov-Gerasimenko indicate that the early-forming cometesimals experienced similar primordial stratified accretion, even though they formed independently.
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4. |
- Pajola, Maurizio, et al.
(author)
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Size-frequency distribution of boulders >= 7 m on comet 67P/Churyumov-Gerasimenko
- 2015
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 583
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Journal article (peer-reviewed)abstract
- Aims. We derive for the first time the size-frequency distribution of boulders on a comet, 67P/Churyumov-Gerasimenko (67P), computed from the images taken by the Rosetta/OSIRIS imaging system. We highlight the possible physical processes that lead to these boulder size distributions. Methods. We used images acquired by the OSIRIS Narrow Angle Camera, NAC. on 5 and 6 August 2014. The scale of these images (2.44-2.03 m/px) is such that boulders >= 7 m can be identified and manually extracted from the datasets with the software ArcGIS. We derived both global and localized size-frequency distributions. The three-pixel sampling detection, coupled with the favorable shadowine of the surface (observation phase angle ranging from 48 to 53), enables unequivocally detecting boulders scattered all over the illuminated side of 67P. Results. We identify 3546 boulders larger than 7 m on the imaged surface (36.4 km(2)), with a global number density of nearly 100/km(2) and a cumulative size-frequency distribution represented by a power-law with index of -3.6 +0.2/-0.3. The two lobes of 67P appear to have slightly different distributions, with an index of -3.5 +0.2/-0.3 for the main lobe (body) and -4.0 +0.31-0.2 for the small lobe (head). The steeper distribution of the small lobe might be due to a more pervasive fracturing. The difference of the distribution for the connecting region (neck) is much more significant, with an index value of -2.2 +0.2/-0.2. We propose that the boulder field located in the neck area is the result of blocks falling from the contiguous Hathor cliff. The lower slope of the size-frequency distribution we see today in the neck area might be due to the concurrent processes acting on the smallest boulders, such as i) disintegration or fragmentation and vanishing through sublimation; ii) uplifting by gas drag and consequent redistribution; and iii) burial beneath a debris blanket. We also derived the cumulative size-frequency distribution per km(2) of localized areas on 67P. By comparing the cumulative size-frequency distributions of similar geomorphological settings, we derived similar power-law index values. This suggests that despite the selected locations on different and often opposite sides of the comet, similar sublimation or activity processes, pit formation or collapses, as well as thermal stresses or fracturing events occurred on multiple areas of the comet, shaping its surface into the appearance we see today.
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5. |
- Sierks, Holger, et al.
(author)
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On the nucleus structure and activity of comet 67P/Churyumov-Gerasimenko
- 2015
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 347:6220
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Journal article (peer-reviewed)abstract
- Images from the OSIRIS scientific imaging system onboard Rosetta show that the nucleus of 67P/Churyumov-Gerasimenko consists of two lobes connected by a short neck. The nucleus has a bulk density less than half that of water. Activity at a distance from the Sun of >3 astronomical units is predominantly from the neck, where jets have been seen consistently. The nucleus rotates about the principal axis of momentum. The surface morphology suggests that the removal of larger volumes of material, possibly via explosive release of subsurface pressure or via creation of overhangs by sublimation, may be a major mass loss process. The shape raises the question of whether the two lobes represent a contact binary formed 4.5 billion years ago, or a single body where a gap has evolved via mass loss.
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6. |
- Thomas, Nicolas, et al.
(author)
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The morphological diversity of comet 67P/Churyumov-Gerasimenko
- 2015
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 347:6220
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Journal article (peer-reviewed)abstract
- Images of comet 67P/Churyumov-Gerasimenko acquired by the OSIRIS (Optical, Spectroscopic and Infrared Remote Imaging System) imaging system onboard the European Space Agency's Rosetta spacecraft at scales of better than 0.8 meter per pixel show a wide variety of different structures and textures. The data show the importance of airfall, surface dust transport, mass wasting, and insolation weathering for cometary surface evolution, and they offer some support for subsurface fluidization models and mass loss through the ejection of large chunks of material.
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7. |
- Vincent, Jean-Baptiste, et al.
(author)
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Large heterogeneities in comet 67P as revealed by active pits from sinkhole collapse
- 2015
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 523:7558, s. 63-66
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Journal article (peer-reviewed)abstract
- Pits have been observed on many cometary nuclei mapped by spacecraft(1-4). It has been argued that cometary pits are a signature of endogenic activity, rather than impact craters such as those on planetary and asteroid surfaces. Impact experiments(5,6) andmodels(7,8) cannot reproduce the shapes of most of the observed cometary pits, and the predicted collision rates imply that few of the pits are related to impacts(8,9). Alternative mechanisms like explosive activity(10) have been suggested, but the driving process remains unknown. Here we report that pits on comet 67P/Churyumov-Gerasimenko are active, and probably created by a sinkhole process, possibly accompanied by outbursts. We argue that after formation, pits expand slowly in diameter, owing to sublimation-driven retreat of the walls. Therefore, pits characterize how eroded the surface is: a fresh cometary surface will have a ragged structure with many pits, while an evolved surface will look smoother. The size and spatial distribution of pits imply that large heterogeneities exist in the physical, structural or compositional properties of the first few hundred metres below the current nucleus surface.
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