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| 2. |
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| 3. |
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| 4. |
- Dunham, I, et al.
(author)
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The DNA sequence of human chromosome 22
- 1999
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 402:6761, s. 489-495
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Journal article (peer-reviewed)
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| 5. |
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| 6. |
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| 7. |
- Gale, S. J., et al.
(author)
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Band termination spectroscopy in 157Er
- 1995
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In: Journal of Physics G: Nuclear and Particle Physics. - 0954-3899. ; 21:2, s. 193-213
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Journal article (peer-reviewed)abstract
- The level scheme of 157Er has been extended from a spin region where the nucleus behaves as a prolate rotor to a region where the spin is produced by the alignment of all or most of the available valence nucleons along the symmetry axis of a weakly deformed oblate shape. The level scheme was established at high spin using up to four-fold gamma -ray coincidences detected in the Eurogam spectrometer following the reaction 114Cd( 48Ca,5n)157Er at a bombarding energy of 210 MeV. Particularly favoured states have been established at IK=69/2+, 81/2+, 71/2+, 77/2-, 87-/2 and 89-/2. Specific single-particle configurations are assigned to these special states by comparison with cranked Nilsson-Strutinsky calculations. These states are related to structures observed in the neighbouring nuclei 158Er and 157Ho. These data provide the spectrum of single-particle states for the lowest lying valence orbitals above the 146Gd closed core.
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| 8. |
- Clark, R M, et al.
(author)
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Superdeformation in bismuth
- 1996
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 53:1, s. 117-123
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Journal article (peer-reviewed)abstract
- High angular momentum states in Bi-195-197 are populated in two reactions: W-183(F-19,xn)Bi-202-x and Ta-181(Ne-20,xn)Bi-201-x at beam energies of 108 and 123 MeV, respectively. Gamma rays were detected using the Gammasphere array. Three weakly populated rotational sequences have been found. They each have properties characteristic of other superdeformed bands in this mass region. On the basis of cross-bombardment information we believe that one band belongs to each of Bi-195, Bi-196, and Bi-197. The properties of the bands in the odd-Bi nuclei are best reproduced if the odd proton occupies the favored signature of the [651]1/2 orbital, while the band in Bi-196 has this same proton configuration coupled to an additional N=7 (j(15/2)) neutron. The relative behavior of the J((2)) moments of inertia can be qualitatively understood in terms of Pauli-blocking effects.
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| 9. |
- Baldsiefen, G, et al.
(author)
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Shears bands in Pb-193
- 1996
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 54:3, s. 1106-1116
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Journal article (peer-reviewed)abstract
- Four bands of enhanced dipole transitions, with weak crossovers, have been observed in Pb-195. Three of these bands are connected to the spherical levels. in addition, the spherical level scheme has been extended. The nuclear spectroscopy was done with the early implementation of GAMMASPHERE and HERA arrays of Get detectors. The nucleus Pb-193 was populated in the Yb-174(Mg-24,5n) reaction at beam energies of 129, 131, and 134 MeV. The experimental results are compared to tilted-axis cranking calculations. The systematical behavior of the dipole bands in the heavier odd-A Pb isotopes, Pb-195,Pb-197,Pb-199,Pb-201, is also discussed.
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| 10. |
- Joss, D T, et al.
(author)
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Lifetime measurements of a triaxial band in Ce-133
- 1998
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In: Acta Physica Hungarica A. - 1219-7580 .- 1588-2675. ; 7:1, s. 111-112
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Journal article (peer-reviewed)abstract
- The Doppler shift attenuation method has been used to determine the transition quadrupole moment of a triaxial band belonging to the gamma-soft nucleus, Ce-133. Doppler broadened lineshape (DBLS) analysis has revealed the magnitude of the Q(t) value to be similar to 2.4 eb. This contribution provides new information of (i) the transition quadrupole moment of this band (ii) the lifetimes of in-band and sidefeeding transitions and (iii) the relative deformations of coexisting nuclear shapes.
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| 11. |
- Joss, D T, et al.
(author)
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Lifetime measurements of a triaxial band in Ce-133
- 1998
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 58:6, s. 3219-3222
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Journal article (peer-reviewed)abstract
- Lifetimes of states within a triaxial band belonging to;the gamma-soft nucleus Ce-133 have been determined through a Doppler-broadened line shape analysis. A value, Q(t)approximate to 2.2 eb, has been found for the transition quadrupole moment which is considerably smaller than that of superdeformed structures (Q(t)approximate to 7.4 e b) in this mass region. The results are discussed in terms of deformation self-consistent calculations based on the total Routhian surface formalism. [S0556-2813(98)01912-8].
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| 12. |
- Asztalos, S J, et al.
(author)
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Spin yields of neutron-rich nuclei from deep inelastic reactions
- 1999
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 60:4
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Journal article (peer-reviewed)abstract
- The potential for using deep inelastic reactions to populate high-spin states in neutron-rich nuclei is studied in a series of experiments using GAMMASPHERE for gamma-ray detection and a silicon strip detector for measuring the angles of projectilelike and targetlike fragments. In three experiments 61 new transitions up to a maximum spin of 22 (h) over bar in 12 neutron-rich rare-earth nuclei were found. We observe that gamma-ray yields as a function of spin are flatter for all neutron transfer products than for inelastic excitation of either the projectile or target nucleus. Calculations are presented which indicate that this difference cannot be accounted for by quasielastic processes, but more likely are the result of larger energy loss processes, such as deep inelastic reactions. [S0556-2813(99)06009-4].
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| 13. |
- Beausang, C W, et al.
(author)
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Lifetimes of yrast and excited superdeformed states in Gd-150 : effect of particle-hole excitations on the deformation
- 1998
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In: Physics Letters B. - 0370-2693 .- 1873-2445. ; 417:1-2, s. 13-19
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Journal article (peer-reviewed)abstract
- The quadrupole moments and deformations have been measured for six superdeformed bands in Gd-150. The results indicate evidence for deformation driving properties of both the high-hi intruder and also low-N natural parity states at the superdeformed Fermi surface. Several new transitions have been identified and placed in the low spin non-yrast portion of one of the SD bands.
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| 14. |
- Clark, R M, et al.
(author)
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Relative deformations of superdeformed bands in Ce-131,Ce-132
- 1996
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In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 76:19, s. 3510-3513
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Journal article (peer-reviewed)abstract
- The quadrupole moments Q(0) of five superdeformed bands in Ce-131,Ce-132 have been established using the Doppler-shift attenuation method; for the first time, we can compare relative deformations of yrast and excited bands in different nuclei to an accuracy of similar or equal to(5-7)%. Four of the five bands have very similar deformations, while the excited band in Ce-131 has a somewhat larger quadrupole moment. Important new information is presented on the shape-driving force of the vi(13/2) orbital, the stability of the second minimum with respect to particle excitations, the relative deformations of identical bands, the nature of the sidefeeding, and the time scale of the decay process.
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| 15. |
- Jonsson, K, et al.
(author)
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Collective excitations and band termination in Nb-85
- 1999
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In: Nuclear Physics A. - 0375-9474 .- 1873-1554. ; 645:1, s. 47-60
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Journal article (peer-reviewed)abstract
- High-spin states in Nb-85 were studied using the GAMMASPHERE Ge detector array and the MICROBALL charged-particle detector system. Three gamma-ray cascades with collective rotational characteristics were observed. One of the bands exhibits a forking at the top, most likely reflecting the termination of one branch into a favoured non-collective, near spherical state. The data are interpreted in terms of cranked Strutinsky-type calculations.
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| 16. |
- LaFosse, D R, et al.
(author)
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Search for hyperdeformation in Gd-146,Gd-147
- 1996
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 54:4, s. 1585-1588
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Journal article (peer-reviewed)abstract
- A search was undertaken to look for evidence of hyperdeformation in Gd-146,Gd-147. Three experiments employing Gammasphere for gamma-ray detection coupled with the Microball for channel selection via charged particle detection were carried out with increasing detection sensitivity and statistics. No definitive evidence for band structures that could be assigned to hyperdeformation could be found. Candidates previously reported are shown not to have properties consistent with a band structure.
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| 17. |
- McNabb, D P, et al.
(author)
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Superdeformation in Po-198
- 1996
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 53:2, s. R541-R543
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Journal article (peer-reviewed)abstract
- The Yb-174(Si-29,5n) reaction at 148 MeV with thin targets was used to populate high-angular momentum states in Po-198. Resulting gamma rays were observed with Gammasphere. A weakly populated superdeformed band of 10 gamma-ray transitions was found and has been assigned to Po-198. This is the first observation of an SD band in the A approximate to 190 region in a nucleus with Z > 83. The J((2))) of the new band is very similar to those of the yrast SD bands in Hg-194 and Pb-196. The intensity profile suggests that this band is populated through states close to where the SD band crosses the yrast line and the angular momentum at which the fission process dominates.
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| 18. |
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| 19. |
- Devlin, M., et al.
(author)
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Superdeformation in 68Zn: Evidence for a New, Neutron-rich Island of Superdeformation in A~70 Nuclei
- 1999
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In: Physical Review Letters. - 1079-7114. ; 82, s. 5217-5220
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Journal article (peer-reviewed)abstract
- A superdeformed rotational structure is reported in the stable nucleus Zn-68. It has a transition quadrupole moment (Q(t)) of 2.5(-0.4)(+0.7) e b (beta(2) approximate to 0.4), as measured by the residual Doppler shift method. Theoretical calculations suggest that two different configurations are possible candidates for this band. One is built without h(11/2) neutrons, as seen in superdeformed bands in the A similar to 60 region, while the other involves one h(11/2) neutron in analogy with superdeformed bands in the A similar to 80 region. The second of these candidate configurations is preferred, thus establishing a new, neutron-rich (relative to the line of beta stability) region of superdeformation with Z similar to 30 and N similar to 38.
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| 20. |
- Kremer, B, et al.
(author)
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Influence of lamotrigine on progression of early Huntington disease : a randomized clinical trial.
- 1999
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In: Neurology. - 0028-3878 .- 1526-632X. ; 53:5, s. 1000-11
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Journal article (peer-reviewed)abstract
- OBJECTIVE: To assess the efficacy of lamotrigine, a novel antiepileptic drug that inhibits glutamate release, to retard disease progression in Huntington disease (HD).BACKGROUND: Excitatory amino acids may cause selective neuronal death in HD, and lamotrigine may inhibit glutamate release in vivo.METHODS: A double-blinded, placebo-controlled study was conducted of 64 patients with motor signs of less than 5 years' duration who were randomly assigned to either placebo or lamotrigine and assessed at 0 (baseline), 12, 24, and 30 months. The primary response variable was total functional capacity (TFC) score. Secondary response variables included the quantified neurological examination and a set of cognitive and motor tests. Repeated fluorodeoxyglucose measurements of regional cerebral metabolism using PET also were included.RESULTS: Fifty-five patients (28 on lamotrigine, 27 on placebo) completed the study. Neither the primary response variable nor any of the secondary response variables differed significantly between the treatment groups. Both the lamotrigine and the placebo group deteriorated significantly on the TFC, in the lamotrigine group by 1.89 and the placebo group by 2.11 points. No effect of CAG size on the rate of deterioration could be detected.CONCLUSIONS: There was no clear evidence that lamotrigine retarded the progression of early Huntington disease over a period of 30 months. However, more patients on lamotrigine reported symptomatic improvement (53.6 versus 14.8%; p = 0.006), and a trend toward decreased chorea was evident in the treated group (p = 0.08). The study also identified various indices of disease progression, including motor tests and PET studies, that were sensitive to deterioration over time.
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| 21. |
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| 22. |
- Bäck, Torbjörn, et al.
(author)
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Observation of superdeformed states in Mo-88
- 1999
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In: European Physical Journal A. - New York : SPRINGER VERLAG. - 1434-6001 .- 1434-601X. ; 6:4, s. 391-397
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Journal article (peer-reviewed)abstract
- High-spin states in Mo-88 were studied using the GAMMASPHERE germanium detector array in conjunction with the MICROBALL CsI(TI) charged-particle detector system. Three gamma-ray cascades with dynamic moments of inertia showing similar characteristics to superdeformed rotational bands observed in the neighbouring A = 80 region have been identified and assigned to the nucleus Mo-88. The quadrupole moment of the strongest band, deduced by the Residual Doppler Shift Method, corresponds to a quadrupole deformation of beta(2) approximate to 0.6. This confirms the superdeformed nature of this band. The experimental data are interpreted in the framework of total routhian surface calculations. All three hands are assigned to two-quasi-particle proton configurations at superdeformed shape.
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| 23. |
- Cederwall, Bo, et al.
(author)
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Favoured superdeformed states in 89TC
- 1999
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In: European Physical Journal A. - New York : Springer-Verlag New York. - 1434-6001 .- 1434-601X. ; 6:3, s. 251-255
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Journal article (peer-reviewed)abstract
- A superdeformed band consisting of a cascade of ten gamma-ray transitions has been identified and assigned to the nucleus Tc-89, close to the proton dripline. The quadrupole moment of the band (Q(t) = 6.7(-2.3)(+3.0) eb, as measured by the Residual Doppler Shift Method) as well as a large dynamic moment of inertia point to a highly elongated shape. With a relative population of approximately 15% of the gamma-ray flux in the Tc-89 exit channel, thp band is among the most intense superdeformed bands observed to date.
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| 24. |
- Boguszewski, C L, et al.
(author)
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Cloning of two novel growth hormone transcripts expressed in human placenta.
- 1998
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In: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 83:8, s. 2878-85
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Journal article (peer-reviewed)abstract
- Several isoforms of human GH (hGH) are produced by two related genes expressed in the pituitary (hGH-N) and in the placenta (hGH-V). These genes consist of five exons (denoted 1-5) separated by four introns (denoted A-D). In the present report, two new transcripts of the hGH-V gene are described. The coding region of the hGH-V gene was amplified by RT-PCR using placental complementary DNA as template. DNA sequencing of several clones revealed two novel transcripts. One had a 45-bp deletion caused by the use of an alternative splice acceptor site within exon 3, similar to that in the hGH-N gene, predicting a 20-kDa isoform of hGH-V. The other transcript was generated by the use of an alternative splice donor site causing a 4-bp deletion in the end of exon 4, predicting a 24-kDa protein with 219 amino acids, which we refer to as hGH-V3. The carboxy-terminal sequence of hGH-V3 differs from 22-kDa hGH-V and hGH-V2, the two previously reported transcripts of the hGH-V gene, and does not contain a predicted transmembrane domain as described for hGH-V2. Ligase chain reaction was then used to analyze the possible use of the same splicing pattern in transcripts derived from the other genes of the hGH-gene cluster. Alternatively spliced transcripts encoding the 20-kDa hGH isoform were detected from the hGH-N and hGH-V genes, but not from the human chorionic somatomammotropin-A/B genes. The alternative splicing generating hGH-V3 was only demonstrated in transcripts derived from the hGH-V gene. Using competitive RT-PCR, the expression of hGH-V3 was estimated to be 10% of the hGH-V messenger RNA in full-term normal placentas and in placentas from pathological pregnancies. The 20-kDa hGH-V was detected in two of four full-term normal placentas, whereas a weak signal was observed in one of the pathological placentas. We conclude that the hGH-V primary transcript undergoes alternative splicing pathways generating at least four different messenger RNAs, predicting the expression of different hGH isoforms, including two with a complete sequence divergence in the carboxy-terminus.
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