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- Dunham, I, et al.
(author)
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The DNA sequence of human chromosome 22
- 1999
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 402:6761, s. 489-495
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Journal article (peer-reviewed)
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- Bullinger, M, et al.
(author)
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The psychological cost of aircraft noise for children
- 1999
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In: International Journal of Hygiene and Environmental Medicine. - 0934-8859. ; 202:2-4, s. 127-138
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Journal article (peer-reviewed)abstract
- Psychological effects of aircraft noise exposure on children have only recently been addressed in the References. The current study took advantage of a natural experiment caused by the opening of a major new airport, exposing children in a formerly quiet area to aircraft noise. In this prospective longitudinal investigation, which employed nan-exposed control groups, effects of aircraft noise prior to and subsequent to inauguration of the new airport as well as effects of chronic noise and its reduction at the old airport (6 and 18 month post relocation), were studied in 326 children aged 9 to 13 years. The psychological health of children was investigated with a standardized quality of life scale as well as with a motivational measure derived from the Glass and Singer stress aftereffects paradigm. In addition a self report noise annoyance scale was used. In the children studied at the two airports over three time points, results showed a significant decrease of total quality of life 18 month after aircraft noise exposure as well as a motivational deficits operationalized by fewer attempts to solve insoluble puzzles in the new airport area. Parallel shifts in children's attributions for failure were also noted. At the old airport parallel impairments were present before the airport relocation but subsided there after. These findings are in accord with reports of impaired psychological health after noise exposure and indicate the relevance of monitoring psychological parameters as a function of environmental stressors among children.
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- Hansson, L. A., et al.
(author)
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Variation in physical, chemical and biological components in the subantarctic lakes of South Georgia
- 1996
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In: Ecography. - : Wiley. - 0906-7590. ; 19:4, s. 393-403
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Journal article (peer-reviewed)abstract
- Physical, chemical and biological variables were quantified in 19 subantarctic lakes (South Georgia) as a prelude to comparing these pristine systems with temperate lakes and to improve the knowledge of spatial and temporal variation in water chemistry and abundances of organisms. Lakes close to the sea had higher phosphorus concentrations, contained higher abundances of most organisms, and had higher number of invertebrate species than lakes situated further from the sea. Differences were attributed to higher nutrient input from marine organisms, such as penguins, seals and petrels, and probably also to a somewhat longer ice-free period. Since the lakes of South Georgia lack fish, the pelagic invertebrate fauna is dominated by herbivorous macrozooplankton. Rotifers are rare in the open water and are restricted to the vegetation (mainly mosses) in shallow areas and to the sediment surface. Generally, the algal abundance at the sediment surface is high in subantarctic lakes, indicating that the main part of the primary production is provided by benthic algae, which is in contrast to what is normally the case in temperate waters.
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- Miller, T. C., et al.
(author)
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Particle astrophysics in antarctica
- 1996
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In: International School of Cosmic Ray Astrophysics: 10th Course: Toward the Millennium in Astrophysics: Problems and Prospects 16-26 Jun 1996. Erice, Italy. ; , s. 157-166
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Conference paper (peer-reviewed)
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- Narod, S A, et al.
(author)
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Oral contraceptives and the risk of hereditary ovarian cancer. Hereditary Ovarian Cancer Clinical Study Group
- 1998
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In: New England Journal of Medicine. - 0028-4793. ; 339:7, s. 8-424
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Journal article (peer-reviewed)abstract
- BACKGROUND: Women with mutations in either the BRCA1 or the BRCA2 gene have a high lifetime risk of ovarian cancer. Oral contraceptives protect against ovarian cancer in general, but it is not known whether they also protect against hereditary forms of ovarian cancer.METHODS: We enrolled 207 women with hereditary ovarian cancer and 161 of their sisters as controls in a case-control study. All the patients carried a pathogenic mutation in either BRCA1 (179 women) or BRCA2 (28 women). The control women were enrolled regardless of whether or not they had either mutation. Lifetime histories of oral-contraceptive use were obtained by interview or by written questionnaire and were compared between patients and control women, after adjustment for year of birth and parity.RESULTS: The adjusted odds ratio for ovarian cancer associated with any past use of oral contraceptives was 0.5 (95 percent confidence interval, 0.3 to 0.8). The risk decreased with increasing duration of use (P for trend, <0.001); use for six or more years was associated with a 60 percent reduction in risk. Oral-contraceptive use protected against ovarian cancer both for carriers of the BRCA1 mutation (odds ratio, 0.5; 95 percent confidence interval, 0.3 to 0.9) and for carriers of the BRCA2 mutation (odds ratio, 0.4; 95 percent confidence interval, 0.2 to 1.1).CONCLUSIONS: Oral-contraceptive use may reduce the risk of ovarian cancer in women with pathogenic mutations in the BRCA1 or BRCA2 gene.
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