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- Ly, John, et al.
(author)
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Semi-automatic analysis of standard uptake values in serial PET/CT studies in patients with lung cancer and lymphoma
- 2012
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In: BMC Medical Imaging. - : Springer Science and Business Media LLC. - 1471-2342. ; 12
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Journal article (peer-reviewed)abstract
- Background: Changes in maximum standardised uptake values (SUVmax) between serial PET/CT studies are used to determine disease progression or regression in oncologic patients. To measure these changes manually can be time consuming in a clinical routine. A semi-automatic method for calculation of SUVmaxin serial PET/CT studies was developed and compared to a conventional manual method. The semi-automatic method first aligns the serial PET/CT studies based on the CT images. Thereafter, the reader selects an abnormal lesion in one of the PET studies. After this manual step, the program automatically detects the corresponding lesion in the other PET study, segments the two lesions and calculates the SUVmaxin both studies as well as the difference between the SUVmaxvalues. The results of the semi-automatic analysis were compared to that of a manual SUVmaxanalysis using a Philips PET/CT workstation. Three readers did the SUVmaxreadings in both methods. Sixteen patients with lung cancer or lymphoma who had undergone two PET/CT studies were included. There were a total of 26 lesions.Results: Linear regression analysis of changes in SUVmaxshow that intercepts and slopes are close to the line of identity for all readers (reader 1: intercept = 1.02, R2= 0.96; reader 2: intercept = 0.97, R2= 0.98; reader 3: intercept = 0.99, R2= 0.98). Manual and semi-automatic method agreed in all cases whether SUVmaxhad increased or decreased between the serial studies. The average time to measure SUVmaxchanges in two serial PET/CT examinations was four to five times longer for the manual method compared to the semi-automatic method for all readers (reader 1: 53.7 vs. 10.5 s; reader 2: 27.3 vs. 6.9 s; reader 3: 47.5 vs. 9.5 s; p < 0.001 for all).Conclusions: Good agreement was shown in assessment of SUVmaxchanges between manual and semi-automatic method. The semi-automatic analysis was four to five times faster to perform than the manual analysis. These findings show the feasibility of using semi-automatic methods for calculation of SUVmaxin clinical routine and encourage further development of programs using this type of methods. © 2012 Ly et al; licensee BioMed Central Ltd.
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- Söderberg, Marcus, et al.
(author)
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Evaluation of image reconstruction methods for 123I-MIBG-SPECT: a rank-order study.
- 2012
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In: Acta Radiologica. - : SAGE Publications. - 1600-0455 .- 0284-1851. ; 53:7, s. 778-784
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Journal article (peer-reviewed)abstract
- Background: There is an opportunity to improve the image quality and lesion detectability in single photon emission computed tomography (SPECT) by choosing an appropriate reconstruction method and optimal parameters for the reconstruction. Purpose: To optimize the use of the Flash 3D reconstruction algorithm in terms of equivalent iteration (EI) number (number of subsets times the number of iterations) and to compare with two recently developed reconstruction algorithms ReSPECT and orthogonal polynomial expansion on disc (OPED) for application on (123)I-metaiodobenzylguanidine (MIBG)-SPECT. Material and Methods: Eleven adult patients underwent SPECT 4 h and 14 patients 24 h after injection of approximately 200 MBq (123)I-MIBG using a Siemens Symbia T6 SPECT/CT. Images were reconstructed from raw data using the Flash 3D algorithm at eight different EI numbers. The images were ranked by three experienced nuclear medicine physicians according to their overall impression of the image quality. The obtained optimal images were then compared in one further visual comparison with images reconstructed using the ReSPECT and OPED algorithms.ResultsThe optimal EI number for Flash 3D was determined to be 32 for acquisition 4 h and 24 h after injection. The average rank order (best first) for the different reconstructions for acquisition after 4 h was: Flash 3D(32) > ReSPECT > Flash 3D(64) > OPED, and after 24 h: Flash 3D(16) > ReSPECT > Flash 3D(32) > OPED. A fair level of inter-observer agreement concerning optimal EI number and reconstruction algorithm was obtained, which may be explained by the different individual preferences of what is appropriate image quality. Conclusion: Using Siemens Symbia T6 SPECT/CT and specified acquisition parameters, Flash 3D(32) (4 h) and Flash 3D(16) (24 h), followed by ReSPECT, were assessed to be the preferable reconstruction algorithms in visual assessment of (123)I-MIBG images.
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