| 1. |
- Ruilope, LM, et al.
(author)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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In: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Journal article (peer-reviewed)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 2. |
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| 3. |
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| 4. |
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| 5. |
- Delafosse, C., et al.
(author)
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Pseudospin Symmetry and Microscopic Origin of Shape Coexistence in the Ni-78 Region : A Hint from Lifetime Measurements
- 2018
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In: Physical Review Letters. - : AMER PHYSICAL SOC. - 0031-9007 .- 1079-7114. ; 121:19
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Journal article (peer-reviewed)abstract
- Lifetime measurements of excited states of the light N = 52 isotones Kr-88, Se-86, and Ge-84 have been performed, using the recoil distance Doppler shift method and VAMOS and AGATA spectrometers for particle identification and gamma spectroscopy, respectively. The reduced electric quadrupole transition probabilities B(E2; 2(+)-> 0(+)) and B(E2; 4(+)-> 2(+)) were obtained for the first time for the hard-to-reach 84Ge. While the B(E2; 2(+)-> 0(+) ) values of Kr-88, Se-86 saturate the maximum quadrupole collectivity offered by the natural valence (3s, 2d, 1g(7/2), 1h(11/2)) space of an inert Ni-78 core, the value obtained for Ge-84 largely exceeds it, suggesting that shape coexistence phenomena, previously reported at N less than or similar to 49, extend beyond N = 50. The onset of collectivity at Z = 32 is understood as due to a pseudo-SU(3) organization of the proton single-particle sequence reflecting a clear manifestation of pseudospin symmetry. It is realized that the latter provides actually reliable guidance for understanding the observed proton and neutron single particle structure in the whole medium-mass region, from Ni to Sn, pointing towards the important role of the isovector-vector rho field in shell-structure evolution.
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| 6. |
- Henrich, C., et al.
(author)
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Coulomb excitation of 142Xe
- 2018
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In: Acta Physica Polonica B. - 0587-4254. ; 49:3, s. 529-533
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Journal article (peer-reviewed)abstract
- The even-even nucleus 142Xe lies north-east of the doubly magic 132Sn on the neutron-rich side of the nuclear chart. In order to gain further information on the octupole collectivity and the evolution of quadrupole collectivity in this region, a "safe" Coulomb excitation experiment was carried out at the new HIE-ISOLDE facility (CERN) at the end of 2016. As the gamma-ray detector the Miniball spectrometer was used. Beam and target nuclei were detected using C-REX, i.e. an array of segmented Si detectors, covering forward as well as backward angles in the laboratory frame.
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| 7. |
- Akiyama, Kazunori, et al.
(author)
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First M87 Event Horizon Telescope Results. I. the Shadow of the Supermassive Black Hole
- 2019
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In: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 875:1
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Journal article (peer-reviewed)abstract
- When surrounded by a transparent emission region, black holes are expected to reveal a dark shadow caused by gravitational light bending and photon capture at the event horizon. To image and study this phenomenon, we have assembled the Event Horizon Telescope, a global very long baseline interferometry array observing at a wavelength of 1.3 mm. This allows us to reconstruct event-horizon-scale images of the supermassive black hole candidate in the center of the giant elliptical galaxy M87. We have resolved the central compact radio source as an asymmetric bright emission ring with a diameter of 42 ±3 μas, which is circular and encompasses a central depression in brightness with a flux ratio ≈10:1. The emission ring is recovered using different calibration and imaging schemes, with its diameter and width remaining stable over four different observations carried out in different days. Overall, the observed image is consistent with expectations for the shadow of a Kerr black hole as predicted by general relativity. The asymmetry in brightness in the ring can be explained in terms of relativistic beaming of the emission from a plasma rotating close to the speed of light around a black hole. We compare our images to an extensive library of ray-traced general-relativistic magnetohydrodynamic simulations of black holes and derive a central mass of M =(6.5 ±0.7) ×10 9 M o . Our radio-wave observations thus provide powerful evidence for the presence of supermassive black holes in centers of galaxies and as the central engines of active galactic nuclei. They also present a new tool to explore gravity in its most extreme limit and on a mass scale that was so far not accessible.
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| 8. |
- Akiyama, Kazunori, et al.
(author)
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First M87 Event Horizon Telescope Results. II. Array and Instrumentation
- 2019
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In: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 875:1
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Journal article (peer-reviewed)abstract
- The Event Horizon Telescope (EHT) is a very long baseline interferometry (VLBI) array that comprises millimeter- and submillimeter-wavelength telescopes separated by distances comparable to the diameter of the Earth. At a nominal operating wavelength of ∼1.3 mm, EHT angular resolution (λ/D) is ∼25 μas, which is sufficient to resolve nearby supermassive black hole candidates on spatial and temporal scales that correspond to their event horizons. With this capability, the EHT scientific goals are to probe general relativistic effects in the strong-field regime and to study accretion and relativistic jet formation near the black hole boundary. In this Letter we describe the system design of the EHT, detail the technology and instrumentation that enable observations, and provide measures of its performance. Meeting the EHT science objectives has required several key developments that have facilitated the robust extension of the VLBI technique to EHT observing wavelengths and the production of instrumentation that can be deployed on a heterogeneous array of existing telescopes and facilities. To meet sensitivity requirements, high-bandwidth digital systems were developed that process data at rates of 64 gigabit s -1 , exceeding those of currently operating cm-wavelength VLBI arrays by more than an order of magnitude. Associated improvements include the development of phasing systems at array facilities, new receiver installation at several sites, and the deployment of hydrogen maser frequency standards to ensure coherent data capture across the array. These efforts led to the coordination and execution of the first Global EHT observations in 2017 April, and to event-horizon-scale imaging of the supermassive black hole candidate in M87.
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| 9. |
- Akiyama, Kazunori, et al.
(author)
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First M87 Event Horizon Telescope Results. III. Data Processing and Calibration
- 2019
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In: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 875:1
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Journal article (peer-reviewed)abstract
- We present the calibration and reduction of Event Horizon Telescope (EHT) 1.3 mm radio wavelength observations of the supermassive black hole candidate at the center of the radio galaxy M87 and the quasar 3C 279, taken during the 2017 April 5-11 observing campaign. These global very long baseline interferometric observations include for the first time the highly sensitive Atacama Large Millimeter/submillimeter Array (ALMA); reaching an angular resolution of 25 μas, with characteristic sensitivity limits of ∼1 mJy on baselines to ALMA and ∼10 mJy on other baselines. The observations present challenges for existing data processing tools, arising from the rapid atmospheric phase fluctuations, wide recording bandwidth, and highly heterogeneous array. In response, we developed three independent pipelines for phase calibration and fringe detection, each tailored to the specific needs of the EHT. The final data products include calibrated total intensity amplitude and phase information. They are validated through a series of quality assurance tests that show consistency across pipelines and set limits on baseline systematic errors of 2% in amplitude and 1° in phase. The M87 data reveal the presence of two nulls in correlated flux density at ∼3.4 and ∼8.3 Gλ and temporal evolution in closure quantities, indicating intrinsic variability of compact structure on a timescale of days, or several light-crossing times for a few billion solar-mass black hole. These measurements provide the first opportunity to image horizon-scale structure in M87.
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| 10. |
- Siciliano, M., et al.
(author)
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STUDY OF QUADRUPOLE CORRELATIONS IN N = Z=5 0 REGION VIA LIFETIME MEASUREMENTS
- 2017
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In: Acta Physica Polonica B. - : Jagiellonian University Press. - 0587-4254 .- 1509-5770. ; 48:3, s. 331-336
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Journal article (peer-reviewed)abstract
- During the AGATA campaign at GANIL, the neutron-deficient Sn region was populated via a multi-nucleon transfer reaction in order to directly measure the lifetime of the first excited states with a plunger device, providing complementary information to previous results obtained with Coulomb excitation experiments. The AGATA gamma-ray array was used together with the VAMOS++ spectrometer to study the nuclei of interest.
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| 11. |
- Clément, E., et al.
(author)
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Low-energy Coulomb excitation of Sr 96,98 beams
- 2016
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In: Physical Review C - Nuclear Physics. - 0556-2813. ; 94:5, s. 054326-
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Journal article (peer-reviewed)abstract
- The structure of neutron-rich Sr96,98 nuclei was investigated by low-energy safe Coulomb excitation of radioactive beams at the REX-ISOLDE facility, CERN, with the MINIBALL spectrometer. A rich set of transitional and diagonal E2 matrix elements, including those for non-yrast structures, has been extracted from the differential Coulomb-excitation cross sections. The results support the scenario of a shape transition at N=60, giving rise to the coexistence of a highly deformed prolate and a spherical configuration in Sr98, and are compared to predictions from several theoretical calculations. The experimental data suggest a significant contribution of the triaxal degree of freedom in the ground state of both isotopes. In addition, experimental information on low-lying states in Rb98 has been obtained.
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| 12. |
- Clément, E, et al.
(author)
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Spectroscopic Quadrupole Moments in ^{96,98}Sr: Evidence for Shape Coexistence in Neutron-Rich Strontium Isotopes at N=60.
- 2016
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In: Physical Review Letters. - 1079-7114. ; 116:2
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Journal article (peer-reviewed)abstract
- Neutron-rich ^{96,98}Sr isotopes have been investigated by safe Coulomb excitation of radioactive beams at the REX-ISOLDE facility. Reduced transition probabilities and spectroscopic quadrupole moments have been extracted from the differential Coulomb excitation cross sections. These results allow, for the first time, the drawing of definite conclusions about the shape coexistence of highly deformed prolate and spherical configurations. In particular, a very small mixing between the coexisting states is observed, contrary to other mass regions where strong mixing is present. Experimental results have been compared to beyond-mean-field calculations using the Gogny D1S interaction in a five-dimensional collective Hamiltonian formalism, which reproduce the shape change at N=60.
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| 13. |
- Mach, Henryk, et al.
(author)
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Ultrafast-timing lifetime measurements in Ru-94 and Pd-96 : Breakdown of the seniority scheme in N=50 isotones
- 2017
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In: PHYSICAL REVIEW C. - : American Physical Society. - 2469-9985. ; 95:1
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Journal article (peer-reviewed)abstract
- The advanced time-delayed gamma gamma(t) method has been applied to determine half-lives of low-lying states in the N = 50 isotones Ru-94 and Pd-96. The inferred experimental E2 strengths for the 4(+) -> 2(+) transitions in the two nuclei show a dramatic deviation with respect to the shell model predictions in the (f(5/2), p, g(9/2)) proton hole space in Sn-100. The anomalous behavior can be ascribed to a breakdown of the seniority quantum number in the pi g(9/2)(n) configuration due to particle-hole excitations across the N = Z = 50 shell as confirmed by large-scale shell model calculations.
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| 14. |
- Ralet, D., et al.
(author)
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Evidence of octupole-phonons at high spin in Pb-207
- 2019
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In: Physics Letters B. - : ELSEVIER. - 0370-2693 .- 1873-2445. ; 797
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Journal article (peer-reviewed)abstract
- A lifetime measurement of the 19/2(-) state in Pb-207 has been performed using the Recoil Distance Doppler-Shift (RDDS) method. The nuclei of interest were produced in multi-nucleon transfer reactions induced by a Pb-208 beam impinging on a Mo-100 enriched target. The beam-like nuclei were detected and identified in terms of their atomic mass number in the VAMOS++ spectrometer while the prompt gamma rays were detected by the AGATA tracking array. The measured large reduced transition probability B(E3, 19/2(-) -> 13/2(+)) = 40(8) W.u. is the first indication of the octupole phonon at high spin in Pb-207. An analysis in terms of a particle-octupole-vibration coupling model indicates that the measured B(E3) value in Pb-207 is compatible with the contributions from single-phonon and single particle E3 as well as E3 strength arising from the double-octupole-phonon 6(+) state, all adding coherently. A crucial aspect of the coupling model, namely the strong mixing between single-hole and the phonon-hole states, is confirmed in a realistic shell-model calculation. Crown Copyright (C) 2019 Published by Elsevier B.V.
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| 15. |
- Klintefjord, M., et al.
(author)
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Measurement of lifetimes in Fe-62,Fe-64, Co-61,Co-63, and Mn-59
- 2017
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In: PHYSICAL REVIEW C. - 2469-9985. ; 95:2
-
Journal article (peer-reviewed)abstract
- Lifetimes of the 4(1)(+) states in Fe-62,Fe-64 and the 11/2(1)(-) states in Co-61,Co-63 and Mn-59 were measured at the Grand Accelerateur National d'Ions Lourds (GANIL) facility by using the Advanced Gamma Tracking Array (AGATA) and the large-acceptance variable mode spectrometer (VAMOS++). The states were populated through multinucleon transfer reactions with a U-238 beam impinging on a Ni-64 target, and lifetimes in the picosecond range were measured by using the recoil distance Doppler shift method. The data show an increase of collectivity in the iron isotopes approaching N = 40. The reduction of the subshell gap between the nu 2p(1/2) and nu 1g(9/2) orbitals leads to an increased population of the quasi-SU(3) pair (nu 1g(9/2), nu 2d(5/2)), which causes an increase in quadrupole collectivity. This is not observed for the cobalt isotopes withN < 40 for which the neutron subshell gap is larger due to the repulsive monopole component of the tensor nucleon-nucleon interaction. The extracted experimental B(E2) values are compared with large-scale shell-model calculations and with beyond-mean-field calculations with the Gogny D1S interaction. A good agreement between calculations and experimental values is found, and the results demonstrate in particular the spectroscopic quality of the Lenzi, Nowacki, Poves, and Sieja (LNPS) shell-model interaction.
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| 16. |
- Porth, Oliver, et al.
(author)
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The Event Horizon General Relativistic Magnetohydrodynamic Code Comparison Project
- 2019
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In: Astrophysical Journal, Supplement Series. - : American Astronomical Society. - 1538-4365 .- 0067-0049. ; 243:2
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Journal article (peer-reviewed)abstract
- Recent developments in compact object astrophysics, especially the discovery of merging neutron stars by LIGO, the imaging of the black hole in M87 by the Event Horizon Telescope, and high- precision astrometry of the Galactic Center at close to the event horizon scale by the GRAVITY experiment motivate the development of numerical source models that solve the equations of general relativistic magnetohydrodynamics (GRMHD). Here we compare GRMHD solutions for the evolution of a magnetized accretion flow where turbulence is promoted by the magnetorotational instability from a set of nine GRMHD codes: Athena++, BHAC, Cosmos++, ECHO, H-AMR, iharm3D, HARM-Noble, IllinoisGRMHD, and KORAL. Agreement among the codes improves as resolution increases, as measured by a consistently applied, specially developed set of code performance metrics. We conclude that the community of GRMHD codes is mature, capable, and consistent on these test problems.
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| 17. |
- Akiyama, Kazunori, et al.
(author)
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First M87 Event Horizon Telescope Results. IV. Imaging the Central Supermassive Black Hole
- 2019
-
In: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 875:1
-
Journal article (peer-reviewed)abstract
- We present the first Event Horizon Telescope (EHT) images of M87, using observations from April 2017 at 1.3 mm wavelength. These images show a prominent ring with a diameter of similar to 40 mu as, consistent with the size and shape of the lensed photon orbit encircling the "shadow" of a supermassive black hole. The ring is persistent across four observing nights and shows enhanced brightness in the south. To assess the reliability of these results, we implemented a two-stage imaging procedure. In the first stage, four teams, each blind to the others' work, produced images of M87 using both an established method (CLEAN) and a newer technique (regularized maximum likelihood). This stage allowed us to avoid shared human bias and to assess common features among independent reconstructions. In the second stage, we reconstructed synthetic data from a large survey of imaging parameters and then compared the results with the corresponding ground truth images. This stage allowed us to select parameters objectively to use when reconstructing images of M87. Across all tests in both stages, the ring diameter and asymmetry remained stable, insensitive to the choice of imaging technique. We describe the EHT imaging procedures, the primary image features in M87, and the dependence of these features on imaging assumptions.
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| 18. |
- Akiyama, Kazunori, et al.
(author)
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First M87 Event Horizon Telescope Results. V. Physical Origin of the Asymmetric Ring
- 2019
-
In: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 875:1
-
Journal article (peer-reviewed)abstract
- The Event Horizon Telescope (EHT) has mapped the central compact radio source of the elliptical galaxy M87 at 1.3 mm with unprecedented angular resolution. Here we consider the physical implications of the asymmetric ring seen in the 2017 EHT data. To this end, we construct a large library of models based on general relativistic magnetohydrodynamic (GRMHD) simulations and synthetic images produced by general relativistic ray tracing. We compare the observed visibilities with this library and confirm that the asymmetric ring is consistent with earlier predictions of strong gravitational lensing of synchrotron emission from a hot plasma orbiting near the black hole event horizon. The ring radius and ring asymmetry depend on black hole mass and spin, respectively, and both are therefore expected to be stable when observed in future EHT campaigns. Overall, the observed image is consistent with expectations for the shadow of a spinning Kerr black hole as predicted by general relativity. If the black hole spin and M87's large scale jet are aligned, then the black hole spin vector is pointed away from Earth. Models in our library of non-spinning black holes are inconsistent with the observations as they do not produce sufficiently powerful jets. At the same time, in those models that produce a sufficiently powerful jet, the latter is powered by extraction of black hole spin energy through mechanisms akin to the Blandford-Znajek process. We briefly consider alternatives to a black hole for the central compact object. Analysis of existing EHT polarization data and data taken simultaneously at other wavelengths will soon enable new tests of the GRMHD models, as will future EHT campaigns at 230 and 345 GHz.
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| 19. |
- Akiyama, Kazunori, et al.
(author)
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First M87 Event Horizon Telescope Results. VI. The Shadow and Mass of the Central Black Hole
- 2019
-
In: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 875:1
-
Journal article (peer-reviewed)abstract
- We present measurements of the properties of the central radio source in M87 using Event Horizon Telescope data obtained during the 2017 campaign. We develop and fit geometric crescent models (asymmetric rings with interior brightness depressions) using two independent sampling algorithms that consider distinct representations of the visibility data. We show that the crescent family of models is statistically preferred over other comparably complex geometric models that we explore. We calibrate the geometric model parameters using general relativistic magnetohydrodynamic (GRMHD) models of the emission region and estimate physical properties of the source. We further fit images generated from GRMHD models directly to the data. We compare the derived emission region and black hole parameters from these analyses with those recovered from reconstructed images. There is a remarkable consistency among all methods and data sets. We find that >50% of the total flux at arcsecond scales comes from near the horizon, and that the emission is dramatically suppressed interior to this region by a factor >10, providing direct evidence of the predicted shadow of a black hole. Across all methods, we measure a crescent diameter of 42 +/- 3 mu as and constrain its fractional width to be
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| 23. |
- Qi, L., et al.
(author)
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Prompt fission gamma-ray emission spectral data for Pu-239(n,f) using fast directional neutrons from the LICORNE neutron source
- 2018
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In: SCIENTIFIC WORKSHOP ON NUCLEAR FISSION DYNAMICS AND THE EMISSION OF PROMPT NEUTRONS AND GAMMA RAYS (THEORY-4). - : EDP Sciences. - 9782759890316
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Conference paper (peer-reviewed)abstract
- Prompt fission gamma-ray spectra (PFGS) have been measured for the Pu-239(n,f) reaction using fast neutrons at E-n =1.81 MeV produced by the LICORNE directional neutron source. The setup makes use of LaBr3 scintillation detectors and PARIS phoswich detectors to measure the emitted prompt fission gamma rays (PFG). The mean multiplicity, average total energy release per fission and average energy of photons are extracted from the unfolded PFGS. These new measurements provide complementary information to other recent work on thermal neutron induced fission of Pu-239 and spontaneous fission of Cf-252.
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