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- Lloyd, MD, et al.
(author)
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Studies on the active site of deacetoxycephalosporin C synthase
- 1999
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In: JOURNAL OF MOLECULAR BIOLOGY. - : ACADEMIC PRESS LTD. - 0022-2836. ; 287:5, s. 943-960
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Journal article (peer-reviewed)abstract
- The Fe(II) and 2-oxogolutarate-dependent dioxygenase deacetoxycephalosporin C synthase (DAOCS) from Streptomyces clavuligerus was expressed at ca 25% of total soluble protein in Escherichia coli and purified by an efficient large-scale procedure. Purified
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3. |
- Valegard, K, et al.
(author)
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Structure of a cephalosporin synthase
- 1998
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In: NATURE. - : MACMILLAN MAGAZINES LTD. - 0028-0836. ; 394:6695, s. 805-809
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Journal article (peer-reviewed)abstract
- Penicillins and cephalosporins are among the most widely used therapeutic agents. These antibiotics are produced from fermentation-derived materials as their chemical synthesis is not commercially viable. Unconventional steps in their biosynthesis are cat
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