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Träfflista för sökning "WFRF:(Hossain MB) srt2:(2015-2019)"

Search: WFRF:(Hossain MB) > (2015-2019)

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1.	Murray, CJL, et al. (author) Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition 2015 In: Lancet (London, England). - 1474-547X .- 0140-6736. ; 386, s. 2145-2191 Journal article (peer-reviewed)
2.	ElBeck, Z, et al. (author) Methylation, Mis-Splicing and Expression of Pathological Isoforms in a Disease Causing Csrp3/Mlp Mutation 2019 In: CIRCULATION. - 0009-7322. ; 140 Conference paper (other academic/artistic)
3.	Esfahani, PH, et al. (author) Cell shape determines gene expression: cardiomyocyte morphotypic transcriptomes 2019 In: Basic research in cardiology. - : Springer Science and Business Media LLC. - 1435-1803 .- 0300-8428. ; 115:1, s. 7- Journal article (peer-reviewed)abstract Cardiomyocytes undergo considerable changes in cell shape. These can be due to hemodynamic constraints, including changes in preload and afterload conditions, or to mutations in genes important for cardiac function. These changes instigate significant changes in cellular architecture and lead to the addition of sarcomeres, at the same time or at a later stage. However, it is currently unknown whether changes in cell shape on their own affect gene expression and the aim of this study was to fill that gap in our knowledge. We developed a single-cell morphotyping strategy, followed by single-cell RNA sequencing, to determine the effects of altered cell shape in gene expression. This enabled us to profile the transcriptomes of individual cardiomyocytes of defined geometrical morphotypes and characterize them as either normal or pathological conditions. We observed that deviations from normal cell shapes were associated with significant downregulation of gene expression and deactivation of specific pathways, like oxidative phosphorylation, protein kinase A, and cardiac beta-adrenergic signaling pathways. In addition, we observed that genes involved in apoptosis of cardiomyocytes and necrosis were upregulated in square-like pathological shapes. Mechano-sensory pathways, including integrin and Src kinase mediated signaling, appear to be involved in the regulation of shape-dependent gene expression. Our study demonstrates that cell shape per se affects the regulation of the transcriptome in cardiac myocytes, an effect with possible implications for cardiovascular disease.
4.	Hossain, MB, et al. (author) Myosin binding protein-C and hypertrophic cardiomyopathy: role of altered C10 domain 2019 In: Cardiovascular research. - : Oxford University Press (OUP). - 1755-3245 .- 0008-6363. ; 115:14, s. 1943-1945 Journal article (peer-reviewed)
5.	Ronco, AM, et al. (author) Increased methylation of tumor suppressor genes p16, MLH1 and MGMT in elderly with high serum folate concentrations 2016 In: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. - 1107-3756. ; 38, s. S54-S54 Conference paper (other academic/artistic)

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Type of publication: journal article (3); conference paper (2)

Type of content: peer-reviewed (3); other academic/artistic (2)

Author/Editor: Jiang, Y. (1); Li, B. (1); Liu, Y. (1); Sliwa, K. (1); Kim, Y. (1); Zhao, Y. (1); show more...; Gupta, R. (1); Kim, S. (1); Kim, D. (1); Weiderpass, E (1); Kivipelto, M (1); Bose, D. (1); Larsson, Anders (1); Tonelli, M. (1); Abd-Allah, F (1); Aboyans, V (1); Abu-Raddad, LJ (1); Ackerman, IN (1); Afshin, A (1); Agardh, EE (1); Alla, F (1); Allebeck, P (1); Alvis-Guzman, N (1); Amare, AT (1); Antonio, CAT (1); Badawi, A (1); Barker-Collo, SL (1); Barrero, LH (1); Basu, S (1); Bedi, N (1); Beghi, E (1); Bell, ML (1); Bennett, DA (1); Bensenor, IM (1); Bernabe, E (1); Bhala, N (1); Bhutta, ZA (1); Bikbov, B (1); Boufous, S (1); Breitborde, NJK (1); Brenner, H (1); Buchbinder, R (1); Campos-Nonato, IR (1); Cardenas, R (1); Castaneda-Orjuela, C ... (1); Catala-Lopez, F (1); Chang, JC (1); Charlson, FJ (1); Chimed-Ochir, O (1); Christensen, H (1); show less...

University: Karolinska Institutet (5); University of Gothenburg (1); Uppsala University (1); Lund University (1); Högskolan Dalarna (1)

Language: English (5)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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