SwePub - search: WFRF:(Julio F)

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1.	Wright, NJ, et al. (author) Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study 2021 In: Lancet (London, England). - 1474-547X. ; 398:10297, s. 325-339 Journal article (peer-reviewed)
2.	Kattge, Jens, et al. (author) TRY plant trait database - enhanced coverage and open access 2020 In: Global Change Biology. - : Wiley-Blackwell. - 1354-1013 .- 1365-2486. ; 26:1, s. 119-188 Journal article (peer-reviewed)abstract Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits-almost complete coverage for 'plant growth form'. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait-environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.
3.	Householder, John Ethan, et al. (author) One sixth of Amazonian tree diversity is dependent on river floodplains 2024 In: NATURE ECOLOGY & EVOLUTION. - 2397-334X. Journal article (peer-reviewed)abstract Amazonia's floodplain system is the largest and most biodiverse on Earth. Although forests are crucial to the ecological integrity of floodplains, our understanding of their species composition and how this may differ from surrounding forest types is still far too limited, particularly as changing inundation regimes begin to reshape floodplain tree communities and the critical ecosystem functions they underpin. Here we address this gap by taking a spatially explicit look at Amazonia-wide patterns of tree-species turnover and ecological specialization of the region's floodplain forests. We show that the majority of Amazonian tree species can inhabit floodplains, and about a sixth of Amazonian tree diversity is ecologically specialized on floodplains. The degree of specialization in floodplain communities is driven by regional flood patterns, with the most compositionally differentiated floodplain forests located centrally within the fluvial network and contingent on the most extraordinary flood magnitudes regionally. Our results provide a spatially explicit view of ecological specialization of floodplain forest communities and expose the need for whole-basin hydrological integrity to protect the Amazon's tree diversity and its function.
4.	Luize, Bruno Garcia, et al. (author) Geography and ecology shape the phylogenetic composition of Amazonian tree communities 2024 In: JOURNAL OF BIOGEOGRAPHY. - 0305-0270 .- 1365-2699. Journal article (peer-reviewed)abstract Aim: Amazonia hosts more tree species from numerous evolutionary lineages, both young and ancient, than any other biogeographic region. Previous studies have shown that tree lineages colonized multiple edaphic environments and dispersed widely across Amazonia, leading to a hypothesis, which we test, that lineages should not be strongly associated with either geographic regions or edaphic forest types. Location: Amazonia. Taxon: Angiosperms (Magnoliids; Monocots; Eudicots). Methods: Data for the abundance of 5082 tree species in 1989 plots were combined with a mega-phylogeny. We applied evolutionary ordination to assess how phylogenetic composition varies across Amazonia. We used variation partitioning and Moran's eigenvector maps (MEM) to test and quantify the separate and joint contributions of spatial and environmental variables to explain the phylogenetic composition of plots. We tested the indicator value of lineages for geographic regions and edaphic forest types and mapped associations onto the phylogeny. Results: In the terra firme and v & aacute;rzea forest types, the phylogenetic composition varies by geographic region, but the igap & oacute; and white-sand forest types retain a unique evolutionary signature regardless of region. Overall, we find that soil chemistry, climate and topography explain 24% of the variation in phylogenetic composition, with 79% of that variation being spatially structured (R-2 = 19% overall for combined spatial/environmental effects). The phylogenetic composition also shows substantial spatial patterns not related to the environmental variables we quantified (R-2 = 28%). A greater number of lineages were significant indicators of geographic regions than forest types. Main Conclusion: Numerous tree lineages, including some ancient ones (>66 Ma), show strong associations with geographic regions and edaphic forest types of Amazonia. This shows that specialization in specific edaphic environments has played a long-standing role in the evolutionary assembly of Amazonian forests. Furthermore, many lineages, even those that have dispersed across Amazonia, dominate within a specific region, likely because of phylogenetically conserved niches for environmental conditions that are prevalent within regions.
5.	ter Steege, Hans, et al. (author) Mapping density, diversity and species-richness of the Amazon tree flora 2023 In: COMMUNICATIONS BIOLOGY. - 2399-3642. ; 6:1 Journal article (peer-reviewed)abstract Using 2.046 botanically-inventoried tree plots across the largest tropical forest on Earth, we mapped tree species-diversity and tree species-richness at 0.1-degree resolution, and investigated drivers for diversity and richness. Using only location, stratified by forest type, as predictor, our spatial model, to the best of our knowledge, provides the most accurate map of tree diversity in Amazonia to date, explaining approximately 70% of the tree diversity and species-richness. Large soil-forest combinations determine a significant percentage of the variation in tree species-richness and tree alpha-diversity in Amazonian forest-plots. We suggest that the size and fragmentation of these systems drive their large-scale diversity patterns and hence local diversity. A model not using location but cumulative water deficit, tree density, and temperature seasonality explains 47% of the tree species-richness in the terra-firme forest in Amazonia. Over large areas across Amazonia, residuals of this relationship are small and poorly spatially structured, suggesting that much of the residual variation may be local. The Guyana Shield area has consistently negative residuals, showing that this area has lower tree species-richness than expected by our models. We provide extensive plot meta-data, including tree density, tree alpha-diversity and tree species-richness results and gridded maps at 0.1-degree resolution. A study mapping the tree species richness in Amazonian forests shows that soil type exerts a strong effect on species richness, probably caused by the areas of these forest types. Cumulative water deficit, tree density and temperature seasonality affect species richness at a regional scale.
6.	Abele, H., et al. (author) Particle physics at the European Spallation Source 2023 In: Physics reports. - : Elsevier. - 0370-1573 .- 1873-6270. ; 1023, s. 1-84 Research review (peer-reviewed)abstract Presently under construction in Lund, Sweden, the European Spallation Source (ESS) will be the world’s brightest neutron source. As such, it has the potential for a particle physics program with a unique reach and which is complementary to that available at other facilities. This paper describes proposed particle physics activities for the ESS. These encompass the exploitation of both the neutrons and neutrinos produced at the ESS for high precision (sensitivity) measurements (searches).
7.	Feng, Shaohong, et al. (author) Dense sampling of bird diversity increases power of comparative genomics 2020 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 587:7833 Journal article (peer-reviewed)abstract Whole-genome sequencing projects are increasingly populating the tree of life and characterizing biodiversity(1-4). Sparse taxon sampling has previously been proposed to confound phylogenetic inference(5), and captures only a fraction of the genomic diversity. Here we report a substantial step towards the dense representation of avian phylogenetic and molecular diversity, by analysing 363 genomes from 92.4% of bird families-including 267 newly sequenced genomes produced for phase II of the Bird 10,000 Genomes (B10K) Project. We use this comparative genome dataset in combination with a pipeline that leverages a reference-free whole-genome alignment to identify orthologous regions in greater numbers than has previously been possible and to recognize genomic novelties in particular bird lineages. The densely sampled alignment provides a single-base-pair map of selection, has more than doubled the fraction of bases that are confidently predicted to be under conservation and reveals extensive patterns of weak selection in predominantly non-coding DNA. Our results demonstrate that increasing the diversity of genomes used in comparative studies can reveal more shared and lineage-specific variation, and improve the investigation of genomic characteristics. We anticipate that this genomic resource will offer new perspectives on evolutionary processes in cross-species comparative analyses and assist in efforts to conserve species. A dataset of the genomes of 363 species from the Bird 10,000 Genomes Project shows increased power to detect shared and lineage-specific variation, demonstrating the importance of phylogenetically diverse taxon sampling in whole-genome sequencing.
8.	Fernández-Alvar, Emma, et al. (author) The Pristine survey XIII : uncovering the very metal-poor tail of the thin disc 2021 In: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 508:1, s. 1509-1525 Journal article (peer-reviewed)abstract We evaluate the rotational velocity of stars observed by the Pristine survey towards the Galactic anticentre spanning a wide range of metallicities from the extremely metal-poor regime ([Fe/H] < −3) to nearly solar metallicity. In the Galactic anticentre direction, the rotational velocity (Vφ) is similar to the tangential velocity in the galactic longitude direction (V). This allows us to estimate Vφ from Gaia early data release 3 (Gaia EDR3) proper motions for stars without radial velocity measurements. This substantially increases the sample of stars in the outer disc with estimated rotational velocities. Our stellar sample towards the anticentre is dominated by a kinematical thin disc with a mean rotation of ∼−220 km s−1. However, our analysis reveals the presence of more stellar substructures. The most intriguing is a well-populated extension of the kinematical thin disc down to [Fe/H] ∼ −2 . A scarcer fast-rotating population reaching the extremely metal-poor regime down to [Fe/H] ∼ −3.5 is also detected but without statistical significance to unambiguously state whether this is the extremely metal-poor extension of the thin disc or the high-rotating tail of hotter structures (like the thick disc or the halo). In addition, a more slowly rotating kinematical thick disc component is also required to explain the observed V distribution at [Fe/H] > −1.5 . Furthermore, we detect signatures of a ‘heated disc’, the so-called Splash, at metallicities higher than ∼−1.5. Finally, at [Fe/H] < −1.5 our anticentre sample is dominated by a kinematical halo with a net prograde motion.
9.	Kielty, Collin L., et al. (author) The Pristine survey - XII. Gemini-GRACES chemo-dynamical study of newly discovered extremely metal-poor stars in the Galaxy 2021 In: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 506:1, s. 1438-1461 Journal article (peer-reviewed)abstract High-resolution optical spectra of 30 metal-poor stars selected from the Pristine survey are presented, based on observations taken with the Gemini Observatory GRACES spectrograph. Stellar parameters Teff and log g are determined using a Gaia DR2 colour–temperature calibration and surface gravity from the Stefan–Boltzmann equation. GRACES spectra are used to determine chemical abundances (or upper limits) for 20 elements (Li, O, Na, Mg, K, Ca, Ti, Sc, Cr, Mn, Fe, Ni, Cu, Zn, Y, Zr, Ba, La, Nd, Eu). These stars are confirmed to be metal-poor ([Fe/H] < −2.5), with higher precision than from earlier medium-resolution analyses. The chemistry for most targets is similar to other extremely metal-poor stars in the Galactic halo. Three stars near [Fe/H] = −3.0 have unusually low Ca and high Mg, suggestive of contributions from few SN II where alpha-element formation through hydrostatic nucleosynthesis was more efficient. Three new carbon-enhanced metal-poor (CEMP) stars are also identified (two CEMP-s and one potential CEMP-no star) when our chemical abundances are combined with carbon from previous medium-resolution analyses. The GRACES spectra also provide precision radial velocities (σRV ≤ 0.2 km s−1) for dynamical orbit calculations with the Gaia DR2 proper motions. Most of our targets are dynamically associated with the Galactic halo; however, five stars with [Fe/H] < −3 have planar-like orbits, including one retrograde star. Another five stars are dynamically consistent with the Gaia-Sequoia accretion event; three have typical halo [α/Fe] ratios for their metallicities, whereas two are [Mg/Fe]-deficient, and one is a new CEMP-s candidate. These results are discussed in terms of the formation and early chemical evolution of the Galaxy.
10.	Thomas, Guillaume F., et al. (author) The Hidden Past of M92 : Detection and Characterization of a Newly Formed 17 degrees Long Stellar Stream Using the Canada-France Imaging Survey 2020 In: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 902:2 Journal article (peer-reviewed)abstract We present an analysis of the structure, kinematics, and orbit of a newly found stellar stream emanating from the globular cluster M92 (NGC 6341). This stream was discovered in an improved matched-filter map of the outer Galaxy, based on a color-color-magnitude diagram, created using photometry from the Canada-France Imaging Survey and the Pan-STARRS 1 3 pi survey. We find the stream to have a length of 17 degrees (2.5 kpc at the distance of M92), a width dispersion of 029(42 pc), and a stellar mass of [3.17 0.89] x 10(4)M(10% of the stellar mass of the current main body of M92). We examine the kinematics of main-sequence, red giant, and blue horizontal branch stars belonging to the stream and that have proper motion measurements from the second data release of Gaia.N-body simulations suggest that the stream was likely formed very recently (during the last similar to 500 Myr) forcing us to question the orbital origin of this ancient, metal-poor globular cluster.
11.	Longeard, Nicolas, et al. (author) The pristine dwarf-galaxy survey - III. Revealing the nature of the Milky Way globular cluster Sagittarius II 2021 In: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 503:2, s. 2754-2762 Journal article (peer-reviewed)abstract We present a new spectroscopic study of the faint Milky Way satellite Sagittarius II. Using multiobject spectroscopy from the Fibre Large Array Multi-Element Spectrograph, we supplement the data set of Longeard et al. with 47 newly observed stars, 19 of which are identified as members of the satellite. These additional member stars are used to put tighter constraints on the dynamics and the metallicity properties of the system. We find a low velocity dispersion of sigma(SgrII)(v) = 1.7 +/- 0.5 km s(-1), in agreement with the dispersion of Milky Way globular clusters of similar luminosity. We confirm the very metal-poor nature of the satellite ([Fe/H](spectro)(SgrII) = -2.23 +/- 0.07) and find that the metallicity dispersion of Sgr II is not resolved, reaching only 0.20 at the 95 per cent confidence limit. No star with a metallicity below -2.5 is confidently detected. Therefore, despite the unusually large size of the system (r(h) = 35.5(-1.2)(-1.4) pc), we conclude that Sgr II is an old and metal-poor globular cluster of the Milky Way.
12.	Longeard, Nicolas, et al. (author) The Pristine dwarf galaxy survey - IV. Probing the outskirts of the dwarf galaxy Bootes I 2022 In: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 516:2, s. 2348-2362 Journal article (peer-reviewed)abstract We present a new spectroscopic study of the dwarf galaxy Boötes I (Boo I) with data from the Anglo-Australian Telescope and its AAOmega spectrograph together with the Two Degree Field multi-object system. We observed 36 high-probability Boo I stars selected using Gaia Early Data Release 3 proper motions and photometric metallicities from the Pristine survey. Out of those, 27 are found to be Boo I stars, resulting in an excellent success rate of 75 per cent at finding new members. Our analysis uses a new pipeline developed to estimate radial velocities and equivalent widths of the calcium triplet lines from Gaussian and Voigt line profile fits. The metallicities of 16 members are derived, including 3 extremely metal-poor stars ([Fe/H] < −3.0), which translates into a success rate of 25 per cent at finding them with the combination of Pristine and Gaia. Using the large spatial extent of our new members that spans up to 4.1 half-light radii and spectroscopy from the literature, we find a systemic velocity gradient of 0.40 ± 0.10 km s−1 arcmin−1 and a small but resolved metallicity gradient of −0.008 ± 0.003 dex arcmin−1. Finally, we show that Boo I is more elongated than previously thought with an ellipticity of ϵ = 0.68 ± 0.15. Its velocity and metallicity gradients as well as its elongation suggest that Boo I may have been affected by tides, a result supported by direct dynamical modelling.
13.	Martin, Nicolas F., et al. (author) The Pristine survey - XVI. The metallicity of 26 stellar streams around the Milky Way detected with the STREAMFINDER in Gaia EDR3 2022 In: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 516:4, s. 5331-5354 Journal article (peer-reviewed)abstract We use the photometric metallicities provided by the panoramic Pristine survey to study the veracity and derive the metallicities of the numerous stellar streams found by the application of the STREAMFINDER algorithm to the Gaia Early Data Release 3 data. All 26 streams present in Pristine show a clear metallicity distribution function, which provides an independent check of the reality of these structures, supporting the reliability of STREAMFINDER in finding streams and the power of Pristine to measure precise metallicities. We further present six candidate structures with coherent phase-space and metallicity signals that are very likely streams. The majority of studied streams are very metal-poor (14 structures with [Fe/H] < −2.0) and include three systems with [Fe/H] < −2.9 (C-11, C-19, and C-20). These streams could be the closest debris of low-luminosity dwarf galaxies or may have originated from globular clusters of significantly lower metallicity than any known current Milky Way globular cluster. Our study shows that the promise of the Gaia data for Galactic Archeology studies can be substantially strengthened by quality photometric metallicities, allowing us to peer back into the earliest epochs of the formation of our Galaxy and its stellar halo constituents.
14.	Sestito, Federico, et al. (author) The Pristine survey – X. A large population of low-metallicity stars permeates the Galactic disc 2020 In: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966 .- 1745-3925 .- 1745-3933. ; 497:1, s. L7-L12 Journal article (peer-reviewed)abstract The orbits of the least chemically enriched stars open a window on the formation of our Galaxy when it was still in its infancy. The common picture is that these low-metallicity stars are distributed as an isotropic, pressure-supported component since these stars were either accreted from the early building blocks of the assembling Milky Way (MW), or were later brought by the accretion of faint dwarf galaxies. Combining the metallicities and radial velocities from the Pristine and LAMOST surveys and Gaia DR2 parallaxes and proper motions for an unprecedented large and unbiased sample of 1027 very metal poor stars at [Fe/H] ≤ −2.5 dex, we show that this picture is incomplete. We find that 31 per cent of the stars that currently reside spatially in the disc (⁠\|Z\|≤3kpc⁠) do not venture outside of the disc plane throughout their orbit. Moreover, this sample shows strong statistical evidence (at the 5.0σ level) of asymmetry in their kinematics, favouring prograde motion. The discovery of this population implies that a significant fraction of stars with iron abundances [Fe/H] ≤ −2.5 dex merged into, formed within, or formed concurrently with the MW disc and that the history of the disc was quiet enough to allow them to retain their disc-like orbital properties, challenging theoretical and cosmological models.
15.	Aimo, Alberto, et al. (author) Cardiac remodelling - Part 2: Clinical, imaging and laboratory findings. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology 2022 In: European Journal of Heart Failure. - : WILEY. - 1388-9842 .- 1879-0844. ; 24:6, s. 944-958 Research review (peer-reviewed)abstract In patients with heart failure, the beneficial effects of drug and device therapies counteract to some extent ongoing cardiac damage. According to the net balance between these two factors, cardiac geometry and function may improve (reverse remodelling, RR) and even completely normalize (remission), or vice versa progressively deteriorate (adverse remodelling, AR). RR or remission predict a better prognosis, while AR has been associated with worsening clinical status and outcomes. The remodelling process ultimately involves all cardiac chambers, but has been traditionally evaluated in terms of left ventricular volumes and ejection fraction. This is the second part of a review paper by the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology dedicated to ventricular remodelling. This document examines the proposed criteria to diagnose RR and AR, their prevalence and prognostic value, and the variables predicting remodelling in patients managed according to current guidelines. Much attention will be devoted to RR in patients with heart failure with reduced ejection fraction because most studies on cardiac remodelling focused on this setting.
16.	Barjesteh van Waalwijk van Doorn-Khosrovani, Sahar, et al. (author) PCM4EU and PRIME-ROSE : Collaboration for implementation of precision cancer medicine in Europe 2024 In: Acta Oncologica. - 1651-226X .- 1651-226X. ; 63, s. 385-391 Journal article (peer-reviewed)abstract BACKGROUND: In the two European Union (EU)-funded projects, PCM4EU (Personalized Cancer Medicine for all EU citizens) and PRIME-ROSE (Precision Cancer Medicine Repurposing System Using Pragmatic Clinical Trials), we aim to facilitate implementation of precision cancer medicine (PCM) in Europe by leveraging the experience from ongoing national initiatives that have already been particularly successful. PATIENTS AND METHODS: PCM4EU and PRIME-ROSE gather 17 and 24 partners, respectively, from 19 European countries. The projects are based on a network of Drug Rediscovery Protocol (DRUP)-like clinical trials that are currently ongoing or soon to start in 11 different countries, and with more trials expected to be established soon. The main aims of both the projects are to improve implementation pathways from molecular diagnostics to treatment, and reimbursement of diagnostics and tumour-tailored therapies to provide examples of best practices for PCM in Europe. RESULTS: PCM4EU and PRIME-ROSE were launched in January and July 2023, respectively. Educational materials, including a podcast series, are already available from the PCM4EU website (http://www.pcm4eu.eu). The first reports, including an overview of requirements for the reimbursement systems in participating countries and a guide on patient involvement, are expected to be published in 2024. CONCLUSION: European collaboration can facilitate the implementation of PCM and thereby provide affordable and equitable access to precision diagnostics and matched therapies for more patients. ble from the PCM4EU website (http://www.pcm4eu.eu). The first reports, including an overview of requirements for the reimbursement systems in participating countries and a guide on patient involvement, are expected to be published in 2024. CONCLUSION: European collaboration can facilitate the implementation of PCM and thereby provide affordable and equitable access to precision diagnostics and matched therapies for more patients.
17.	Bissell, Malenka M., et al. (author) 4D Flow cardiovascular magnetic resonance consensus statement : 2023 update 2023 In: Journal of Cardiovascular Magnetic Resonance. - : BMC. - 1097-6647 .- 1532-429X. ; 25:1 Research review (peer-reviewed)abstract Hemodynamic assessment is an integral part of the diagnosis and management of cardiovascular disease. Four-dimensional cardiovascular magnetic resonance flow imaging (4D Flow CMR) allows comprehensive and accurate assessment of flow in a single acquisition. This consensus paper is an update from the 2015 ‘4D Flow CMR Consensus Statement’. We elaborate on 4D Flow CMR sequence options and imaging considerations. The document aims to assist centers starting out with 4D Flow CMR of the heart and great vessels with advice on acquisition parameters, post-processing workflows and integration into clinical practice. Furthermore, we define minimum quality assurance and validation standards for clinical centers. We also address the challenges faced in quality assurance and validation in the research setting. We also include a checklist for recommended publication standards, specifically for 4D Flow CMR. Finally, we discuss the current limitations and the future of 4D Flow CMR. This updated consensus paper will further facilitate widespread adoption of 4D Flow CMR in the clinical workflow across the globe and aid consistently high-quality publication standards.
18.	Callen, Michael, et al. (author) COVID-19 vaccine acceptance and hesitancy in low- and middle-income countries 2021 In: Nature Medicine. - : Springer Nature. - 1546-170X .- 1078-8956. ; 27:8, s. 1385-1394 Journal article (peer-reviewed)abstract Widespread acceptance of COVID-19 vaccines is crucial for achieving sufficient immunization coverage to end the global pandemic, yet few studies have investigated COVID-19 vaccination attitudes in lower-income countries, where large-scale vaccination is just beginning. We analyze COVID-19 vaccine acceptance across 15 survey samples covering 10 low- and middle-income countries (LMICs) in Asia, Africa and South America, Russia (an upper-middle-income country) and the United States, including a total of 44,260 individuals. We find considerably higher willingness to take a COVID-19 vaccine in our LMIC samples (mean 80.3%; median 78%; range 30.1 percentage points) compared with the United States (mean 64.6%) and Russia (mean 30.4%). Vaccine acceptance in LMICs is primarily explained by an interest in personal protection against COVID-19, while concern about side effects is the most common reason for hesitancy. Health workers are the most trusted sources of guidance about COVID-19 vaccines. Evidence from this sample of LMICs suggests that prioritizing vaccine distribution to the Global South should yield high returns in advancing global immunization coverage. Vaccination campaigns should focus on translating the high levels of stated acceptance into actual uptake. Messages highlighting vaccine efficacy and safety, delivered by healthcare workers, could be effective for addressing any remaining hesitancy in the analyzed LMICs. © 2021, The Author(s).
19.	Gonzalez, Arantxa, et al. (author) Cardiac remodelling - Part 1: From cells and tissues to circulating biomarkers. A review from the Study Group on Biomarkers of the Heart Failure Association of the European Society of Cardiology 2022 In: European Journal of Heart Failure. - : WILEY. - 1388-9842 .- 1879-0844. ; 24:6, s. 927-943 Research review (peer-reviewed)abstract Cardiac remodelling refers to changes in left ventricular structure and function over time, with a progressive deterioration that may lead to heart failure (HF) development (adverse remodelling) or vice versa a recovery (reverse remodelling) in response to HF treatment. Adverse remodelling predicts a worse outcome, whilst reverse remodelling predicts a better prognosis. The geometry, systolic and diastolic function and electric activity of the left ventricle are affected, as well as the left atrium and on the long term even right heart chambers. At a cellular and molecular level, remodelling involves all components of cardiac tissue: cardiomyocytes, fibroblasts, endothelial cells and leucocytes. The molecular, cellular and histological signatures of remodelling may differ according to the cause and severity of cardiac damage, and clearly to the global trend toward worsening or recovery. These processes cannot be routinely evaluated through endomyocardial biopsies, but may be reflected by circulating levels of several biomarkers. Different classes of biomarkers (e.g. proteins, non-coding RNAs, metabolites and/or epigenetic modifications) and several biomarkers of each class might inform on some aspects on HF development, progression and long-term outcomes, but most have failed to enter clinical practice. This may be due to the biological complexity of remodelling, so that no single biomarker could provide great insight on remodelling when assessed alone. Another possible reason is a still incomplete understanding of the role of biomarkers in the pathophysiology of cardiac remodelling. Such role will be investigated in the first part of this review paper on biomarkers of cardiac remodelling.
20.	Gunn, Virginia, et al. (author) Non-Standard Employment and Unemployment during the COVID-19 Crisis : Economic and Health Findings from a Six-Country Survey Study 2022 In: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1661-7827 .- 1660-4601. ; 19:10 Journal article (peer-reviewed)abstract The COVID-19 crisis is a global event that has created and amplified social inequalities, including an already existing and steadily increasing problem of employment and income insecurity and erosion of workplace rights, affecting workers globally. The aim of this exploratory study was to review employment-related determinants of health and health protection during the pandemic, or more specifically, to examine several links between non-standard employment, unemployment, economic, health, and safety outcomes during the COVID-19 pandemic in Sweden, Belgium, Spain, Canada, the United States, and Chile, based on an online survey conducted from November 2020 to June 2021. The study focused on both non-standard workers and unemployed workers and examined worker outcomes in the context of current type and duration of employment arrangements, as well as employment transitions triggered by the COVID-19 crisis. The results suggest that COVID-19-related changes in non-standard worker employment arrangements, or unemployment, are related to changes in work hours, income, and benefits, as well as the self-reported prevalence of suffering from severe to extreme anxiety or depression. The results also suggest a link between worker type, duration of employment arrangements, or unemployment, and the ability to cover regular expenses during the pandemic. Additionally, the findings indicate that the type and duration of employment arrangements are related to the provision of personal protective equipment or other COVID-19 protection measures. This study provides additional evidence that workers in non-standard employment and the unemployed have experienced numerous and complex adverse effects of the pandemic and require additional protection through tailored pandemic responses and recovery strategies.
21.	Hwang, Bernice, et al. (author) The impact of insect herbivory on biogeochemical cycling in broadleaved forests varies with temperature 2024 In: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1 Journal article (peer-reviewed)abstract Herbivorous insects alter biogeochemical cycling within forests, but the magnitude of these impacts, their global variation, and drivers of this variation remain poorly understood. To address this knowledge gap and help improve biogeochemical models, we established a global network of 74 plots within 40 mature, undisturbed broadleaved forests. We analyzed freshly senesced and green leaves for carbon, nitrogen, phosphorus and silica concentrations, foliar production and herbivory, and stand-level nutrient fluxes. We show more nutrient release by insect herbivores at non-outbreak levels in tropical forests than temperate and boreal forests, that these fluxes increase strongly with mean annual temperature, and that they exceed atmospheric deposition inputs in some localities. Thus, background levels of insect herbivory are sufficiently large to both alter ecosystem element cycling and influence terrestrial carbon cycling. Further, climate can affect interactions between natural populations of plants and herbivores with important consequences for global biogeochemical cycles across broadleaved forests.
22.	Mesman, Jorrit P., 1993-, et al. (author) The role of internal feedbacks in shifting deep lake mixing regimes under a warming climate 2021 In: Freshwater Biology. - : John Wiley & Sons. - 0046-5070 .- 1365-2427. ; 66:6, s. 1021-1035 Research review (peer-reviewed)abstract Climate warming is causing changes in the physics of deep lakes, such as longer summer stratification, increased water column stability, reduced ice cover, and a shallower depth of winter overturns. An ultimate consequence of warming would be a transition to a different mixing regime. Here we investigate the role of physical, chemical, and biological feedback mechanisms that unfold during a shift in mixing regime, and whether these feedbacks could prompt and stabilise the new regime. Although climate, interannual temperature variation, and lake morphometry are the main determinants of a mixing regime, when climate change causes shifts in mixing regime, internal feedback mechanisms may gain in importance and modify lake ecosystem functioning.We review the role of these feedbacks in three mixing regime shifts: from polymictic to seasonally stratified, from dimictic to monomictic, and from holomictic to oligomictic or meromictic.Polymictic lakes of intermediate depth (c. 3–10 m mean depth) could experience seasonal stratification if a stratification event triggers phytoplankton blooms or dissolved organic matter release, reducing transparency and therefore further heating the surface layer. However, this feedback is only likely to have influence in small and clear lakes, it would be easily disturbed by weather conditions, and the resulting stratified state does not remain stable in the long term, as stratification is lost in winter.The ice-albedo feedback might cause an accelerated shift from ice-covered (dimictic) to ice-free (monomictic) winters in sufficiently deep (mean depth 50 m or more) lakes, where temperature memory is carried over from one winter to the next. Nevertheless, there is an ongoing debate into whether this process can persist during natural weather variations and overcome self-stabilising mechanisms such as thermal insulation by snow. The majority of studies suggest that a gradual transition from dimictic to monomictic is more likely than an abrupt transition.A shift from a holomictic to a meromictic regime can occur if anoxia is triggered by incomplete mixing and an increase in deep-water density—through the accumulation of solutes—exceeds a density decrease by hypolimnetic warming. A shift to meromixis would strongly alter the biology of a lake and might be difficult to reverse. If solutes accumulate only minimally in the hypolimnion, an oligomictic regime is formed, in which years with complete and incomplete mixing alternate.Understanding the importance of feedback mechanisms and the role of biogeochemistry when lakes shift in mixing regime could lead to a better understanding of how climate change affects lake ecosystems.
23.	Nunez, Julio, et al. (author) Congestion in heart failure: a circulating biomarker-based perspective. A review from the Biomarkers Working Group of the Heart Failure Association, European Society of Cardiology 2022 In: European Journal of Heart Failure. - : WILEY. - 1388-9842 .- 1879-0844. ; 24:10, s. 1751-1766 Research review (peer-reviewed)abstract Congestion is a cardinal sign of heart failure (HF). In the past, it was seen as a homogeneous epiphenomenon that identified patients with advanced HF. However, current evidence shows that congestion in HF varies in quantity and distribution. This updated view advocates for a congestive-driven classification of HF according to onset (acute vs. chronic), regional distribution (systemic vs. pulmonary), compartment of distribution (intravascular vs. extravascular), and clinical vs. subclinical. Thus, this review will focus on the utility of circulating biomarkers for assessing and managing the different fluid overload phenotypes. This discussion focused on the clinical utility of the natriuretic peptides, carbohydrate antigen 125 (also called mucin 16), bio-adrenomedullin and mid-regional pro-adrenomedullin, ST2 (also known as interleukin-1 receptor-like 1), cluster of differentiation 146, troponin, C-terminal pro-endothelin-1, and parameters of haemoconcentration. The utility of circulation biomarkers on top of clinical evaluation, haemodynamics, and imaging needs to be better determined by dedicated studies. Some multiparametric frameworks in which these tools contribute to management are proposed.
24.	Reinl, Kaitlin L., et al. (author) Cyanobacterial blooms in oligotrophic lakes : Shifting the high-nutrient paradigm 2021 In: Freshwater Biology. - : John Wiley & Sons. - 0046-5070 .- 1365-2427. ; 66:9, s. 1846-1859 Journal article (peer-reviewed)abstract Freshwater cyanobacterial blooms have become ubiquitous, posing major threats to ecological and public health. Decades of research have focused on understanding drivers of these blooms with a primary focus on eutrophic systems; however, cyanobacterial blooms also occur in oligotrophic systems, but have received far less attention, resulting in a gap in our understanding of cyanobacterial blooms overall. In this review, we explore evidence of cyanobacterial blooms in oligotrophic freshwater systems and provide explanations for those occurrences. We show that through their unique physiological adaptations, cyanobacteria are able to thrive under a wide range of environmental conditions, including low-nutrient waterbodies. We contend that to fully understand cyanobacterial blooms, and thereby mitigate and manage them, we must expand our inquiries to consider systems along the trophic gradient, and not solely focus on eutrophic systems, thus shifting the high-nutrient paradigm to a trophic-gradient paradigm.
25.	Sangeorzan, Irina, et al. (author) Toward Shared Decision-Making in Degenerative Cervical Myelopathy : Protocol for a Mixed Methods Study 2023 In: JMIR Research Protocols. - : JMIR Publications. - 1929-0748. ; 12 Journal article (peer-reviewed)abstract Background: Health care decisions are a critical determinant in the evolution of chronic illness. In shared decision-making (SDM), patients and clinicians work collaboratively to reach evidence-based health decisions that align with individual circumstances, values, and preferences. This personalized approach to clinical care likely has substantial benefits in the oversight of degenerative cervical myelopathy (DCM), a type of nontraumatic spinal cord injury. Its chronicity, heterogeneous clinical presentation, complex management, and variable disease course engenders an imperative for a patient-centric approach that accounts for each patient's unique needs and priorities. Inadequate patient knowledge about the condition and an incomplete understanding of the critical decision points that arise during the course of care currently hinder the fruitful participation of health care providers and patients in SDM. This study protocol presents the rationale for deploying SDM for DCM and delineates the groundwork required to achieve this.Objective: The study's primary outcome is the development of a comprehensive checklist to be implemented upon diagnosis that provides patients with essential information necessary to support their informed decision-making. This is known as a core information set (CIS). The secondary outcome is the creation of a detailed process map that provides a diagrammatic representation of the global care workflows and cognitive processes involved in DCM care. Characterizing the critical decision points along a patient's journey will allow for an effective exploration of SDM tools for routine clinical practice to enhance patient-centered care and improve clinical outcomes.Methods: Both CISs and process maps are coproduced iteratively through a collaborative process involving the input and consensus of key stakeholders. This will be facilitated by Myelopathy.org, a global DCM charity, through its Research Objectives and Common Data Elements for Degenerative Cervical Myelopathy community. To develop the CIS, a 3-round, web-based Delphi process will be used, starting with a baseline list of information items derived from a recent scoping review of educational materials in DCM, patient interviews, and a qualitative survey of professionals. A priori criteria for achieving consensus are specified. The process map will be developed iteratively using semistructured interviews with patients and professionals and validated by key stakeholders.Results: Recruitment for the Delphi consensus study began in April 2023. The pilot-testing of process map interview participants started simultaneously, with the formulation of an initial baseline map underway.Conclusions: This protocol marks the first attempt to provide a starting point for investigating SDM in DCM. The primary work centers on developing an educational tool for use in diagnosis to enable enhanced onward decision-making. The wider objective is to aid stakeholders in developing SDM tools by identifying critical decision junctures in DCM care. Through these approaches, we aim to provide an exhaustive launchpad for formulating SDM tools in the wider DCM community.

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