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- Ruilope, LM, et al.
(author)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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In: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Journal article (peer-reviewed)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 4. |
- Alarcon, Emilio I., et al.
(author)
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Safety and efficacy of composite collagen-silver nanoparticle hydrogels as tissue engineering scaffolds
- 2015
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In: Nanoscale. - : Royal Society of Chemistry. - 2040-3364 .- 2040-3372. ; 7:44, s. 18789-18798
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Journal article (peer-reviewed)abstract
- The increasing number of multidrug resistant bacteria has revitalized interest in seeking alternative sources for controlling bacterial infection. Silver nanoparticles (AgNPs), are amongst the most promising candidates due to their wide microbial spectrum of action. In this work, we report on the safety and efficacy of the incorporation of collagen coated AgNPs into collagen hydrogels for tissue engineering. The resulting hybrid materials at [AgNPs] less than0.4 mu M retained the mechanical properties and biocompatibility for primary human skin fibroblasts and keratinocytes of collagen hydrogels; they also displayed remarkable anti-infective properties against S. aureus, S. epidermidis, E. coli and P. aeruginosa at considerably lower concentrations than silver nitrate. Further, subcutaneous implants of materials containing 0.2 mu M AgNPs in mice showed a reduction in the levels of IL-6 and other inflammation markers (CCL24, sTNFR-2, and TIMP1). Finally, an analysis of silver contents in implanted mice showed that silver accumulation primarily occurred within the tissue surrounding the implant.
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| 6. |
- Glover, Adrian G, et al.
(author)
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Abyssal fauna of the UK-1 polymetallic nodule exploration claim, Clarion-Clipperton Zone, central Pacific Ocean: Echinodermata.
- 2016
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In: Biodiversity data journal. - 1314-2828. ; 4
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Journal article (peer-reviewed)abstract
- We present data from a DNA taxonomy register of the abyssal benthic Echinodermata collected as part of the Abyssal Baseline (ABYSSLINE) environmental survey cruise 'AB01' to the UK Seabed Resources Ltd (UKSRL) polymetallic-nodule exploration claim 'UK-1' in the eastern Clarion-Clipperton Zone (CCZ), central Pacific Ocean abyssal plain. Morphological and genetic data are presented for 17 species (4 Asteroidea, 4 Crinoidea, 2 Holothuroidea and 7 Ophiuroidea) identified by a combination of morphological and genetic data. No taxa matched previously published genetic sequences, but 8 taxa could be assigned to previously-described species based on morphology, although here we have used a precautionary approach in taxon assignments to avoid over-estimating species ranges. The Clarion-Clipperton Zone is a region undergoing intense exploration for potential deep-sea mineral extraction. We present these data to facilitate future taxonomic and environmental impact study by making both data and voucher materials available through curated and accessible biological collections.
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| 7. |
- Schwebel, Frank J, et al.
(author)
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Does mindfulness moderate the relationship between protective behavioral strategies and alcohol use in high school seniors?
- 2015
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In: Alcoholism: Clinical and Experimental Research. - : John Wiley & Sons. ; 39:S1, s. 146A-146A
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Journal article (other academic/artistic)abstract
- Decreases in alcohol consumptions have been linked to the use of protective behavioral strategies (PBS) a number of times (Arterberry et al., 2014; Kenny et al., 2014; & Braitman et al., 2014). Trait mindfulness has been researched looking for a link in substance use treatment. Promising results have been found (Grow et al., 2015; Vinci et al., 2014) that have led to the creation of treatment modalities such as Mindfulness-Based Relapse Prevention (Bowen, Charla, Marlatt, 2010). The present study investigates the relation between PBS, mindfulness, and negative outcomes due to alcohol consumption. The participants are part of a larger study (N = 3,352) investigating a brief online alcohol use intervention amongWashington state (n = 1,181) and Swedish high school seniors (n = 2,171). Data was collected at a six-month follow-up via an online survey. Participants completed the 15-item Protective Behavioral Strategies Scale that measures PBS with responses ranging from 1-Never to 6-Always (PBSS; Martens et al., 2007); a 12-item trait mindfulness measure with responses ranging from1-Rarely/Not at all to 4-Almost always (Cognitive and AffectiveMindfulness Scale Revised; Feldman et al., 2007); and the Young Adult Alcohol Problem Screening Test (Hurlbut & Sher, 1992), which measures social and personal problems related to drinking. A regression analysis was performed to assess the relationship between the measures. Significant main effects were found for PBS (p < 0.001) and mindfulness (p < 0.01) on negative consequences of alcohol use. However, there was no moderating effect of mindfulness on the relation between PBS and negative effects of alcohol (p = 0.10). Results support past research on the impact of mindfulness on negative effects of alcohol. Results regarding PBS were not consistent with past literature regarding their impact on decreasing negative effects of alcohol. This may be attributed to a relationship between those individuals using PBS and the amount of negative drinking consequences they already experience. There was not enough evidence to suggest amoderating effect ofmindfulness as a factor that would further decrease negative alcohol effects. Future research could investigate whether a treatment designed to increase the effectiveness of PBS through increased mindfulness is a suitable intervention. This research was supported by NIAAA # 5R01AA018276 awarded to Drs. Larimer & Berglund.
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- Valenstein-Mah, Helen, et al.
(author)
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Facets of mindfulness predict drinking consequences in a sample of American and Swedish adolescents
- 2015
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In: Alcoholism: Clinical and Experimental Research. - : John Wiley & Sons. ; 39:S1, s. 146A-146A
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Journal article (other academic/artistic)abstract
- Mindfulness-based interventions have become increasingly utilized with individuals with alcohol and substance use disorders (e.g., Bowen et al., 2014); however, the relationship between mindfulness and substance use is complex (Karyadi et al., 2014). Mindfulness is a multifaceted construct and includes factors related to attentional control, present moment focus, and an attitude of non-judgment and acceptance. Thus, the relationship between different mindfulness factors and substance use, and negative consequences related to its use, may differ. In the present study, we examined which specific elements of mindfulness would best predict drinking consequences 6 months later in a sample of American and Swedish adolescents. Additionally, we examined whether adolescents’ nationality would moderate the relationship between mindfulness and drinking consequences. Our sample included Washington St, USA and Swedish adolescents participating in a larger study investigating a brief online intervention for alcohol use (N = 3,352). Participants completed an online survey at 6- and 12-month follow up. At the 6-month follow up, trait-mindfulness wasmeasured using the Cognitive and AffectiveMindfulness Scale-Revised (Feldman et al., 2007). At 12-month follow up, alcohol related negative consequences were measured using the Rutgers Alcohol Problem Index (White & Lobouvie, 1989). Linear regression analysis revealed that mindfulness factors did explain a significant proportion of variance in drinking consequences scores, R2 = 0.02, F(4, 620) = 2.67, p = 0.03. Specifically, the mindfulness factor of attention predicted drinking consequences, such that lower levels of attention predictedmore drinking consequences, b = 0.23, p = 0.02. None of the other mindfulness factors significantly predicted drinking consequences. Adolescents’ nationality did notmoderate the relationship between the mindfulness factors and drinking consequences 6 month later. The present study findings differ from previous findings, which found a relationship between awareness and drinking consequences (Fernandez et al., 2010), although this may be due to differences in how mindfulness factors were conceptualized and assessed. Nationality was not shown to moderate the relationship between mindfulness factors and drinking consequences, suggesting that mindfulness factors may not be culturally bound and may operate consistently across cultures, although examination of additional cultures is needed.
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