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1.	Abbafati, C, et al. (author) Five insights from the Global Burden of Disease Study 2019 2020 In: Lancet (London, England). - 1474-547X .- 0140-6736. ; 396:10258, s. 1135-1159 Journal article (peer-reviewed)
2.	Wang, HD, et al. (author) Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019 2020 In: Lancet (London, England). - 1474-547X .- 0140-6736. ; 396:10258, s. 1160-1203 Journal article (peer-reviewed)
3.	Abbafati, Cristiana, et al. (author) 2020 Journal article (peer-reviewed)
4.	Uddin, Md Sahab, et al. (author) Emerging Promise of Cannabinoids for the Management of Pain and Associated Neuropathological Alterations in Alzheimer's Disease 2020 In: Frontiers in Pharmacology. - : Frontiers Media SA. - 1663-9812. ; 11 Research review (peer-reviewed)abstract Alzheimer's disease (AD) is an irreversible chronic neurodegenerative disorder that occurs when neurons in the brain degenerate and die. Pain frequently arises in older patients with neurodegenerative diseases including AD. However, the presence of pain in older people is usually overlooked with cognitive dysfunctions. Most of the times dementia patients experience moderate to severe pain but the development of severe cognitive dysfunctions tremendously affects their capability to express the presence of pain. Currently, there are no effective treatments against AD that emphasize the necessity for increasing research to develop novel drugs for treating or preventing the disease process. Furthermore, the prospective therapeutic use of cannabinoids in AD has been studied for the past few years. In this regard, targeting the endocannabinoid system has considered as a probable therapeutic strategy to control several associated pathological pathways, such as mitochondrial dysfunction, excitotoxicity, oxidative stress, and neuroinflammation for the management of AD. In this review, we focus on recent studies about the role of cannabinoids for the treatment of pain and related neuropathological changes in AD.

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Type of publication: journal article (3); research review (1)

Type of content: peer-reviewed (4)

Author/Editor: Park, J (2); Gupta, R. (2); Martini, S. (2); Rezaei, N (2); Kumar, P. (2); Tonelli, M. (2); show more...; Han, C. (2); Abbas, KM (2); Abbasifard, M (2); Abbasi-Kangevari, M (2); Abbastabar, H (2); Abd-Allah, F (2); Abdelalim, A (2); Abolhassani, H (2); Abreu, LG (2); Abrigo, MRM (2); Abushouk, AI (2); Adabi, M (2); Adair, T (2); Adebayo, OM (2); Adedeji, IA (2); Adekanmbi, V (2); Adeoye, AM (2); Adetokunboh, OO (2); Advani, SM (2); Afshin, A (2); Aghaali, M (2); Agrawal, A (2); Ahmadi, K (2); Ahmadieh, H (2); Ahmed, MB (2); Al-Aly, Z (2); Alam, K (2); Alam, T (2); Alanezi, FM (2); Alanzi, TM (2); Alcalde-Rabanal, JE (2); Ali, M (2); Alicandro, G (2); Alijanzadeh, M (2); Alinia, C (2); Alipour, V (2); Alizade, H (2); Aljunid, SM (2); Allebeck, P (2); Almadi, MAH (2); Almasi-Hashiani, A (2); Al-Mekhlafi, HM (2); Altirkawi, KA (2); Alumran, AK (2); show less...

University: Uppsala University (4); Karolinska Institutet (3); Högskolan Dalarna (3); University of Gothenburg (1)

Language: English (4)

Research subject (UKÄ/SCB): Medical and Health Sciences (4)

Year: 2020 (4)Undo refine

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