| 1. |
- Aad, G., et al.
(author)
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- 2010
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swepub:Mat__t
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| 2. |
- Aad, G., et al.
(author)
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- 2010
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swepub:Mat__t
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| 3. |
- Aad, G., et al.
(author)
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- 2011
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swepub:Mat__t
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| 4. |
- Aad, G., et al.
(author)
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- 2010
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swepub:Mat__t
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| 5. |
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| 6. |
- Aad, G., et al.
(author)
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- 2010
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swepub:Mat__t
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| 7. |
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| 8. |
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| 9. |
- Aliev, M., et al.
(author)
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A forward silicon strip system for the ATLAS HL-LHC upgrade
- 2013
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In: Nuclear Instruments and Methods in Physics Research Section A. - : Elsevier BV. - 0168-9002 .- 1872-9576. ; 730, s. 210-214
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Journal article (peer-reviewed)abstract
- In the year 2022 an upgrade of the Large Hadron Collider (LHC) is planned to increase the luminosity such that an integrated luminosity of L-int similar to 3000 fb(-1) can be accumulated by 2030 [1]. The radiation damage of the present inner tracker at this date and the high track density of the High Luminosity LHC (HL-LHC) require an upgrade of the inner tracker of the ATLAS (A Toroidal LHC ApparatuS) experiment. A new integration concept will be used: the readout electronics is directly glued on the strip surface of the silicon sensors and the sensors are glued to a support structure. For the barrel region this structure is referred to as a Stave and for the end-cap region it is referred to as a Petal. For tests a smaller version, the Petalet, will be build with two design concepts. In this article the construction method is explained and first hybrid test results for one Petalet sensor are presented.
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| 10. |
- Saenz, R., et al.
(author)
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Activity of the HMGB1-derived immunostimulatory peptide Hp91 resides in the helical C-terminal portion and is enhanced by dimerization
- 2014
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In: Molecular Immunology. - : Elsevier. - 0161-5890 .- 1872-9142. ; 57:2, s. 191-199
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Journal article (peer-reviewed)abstract
- We have previously shown that an 18 amino acid long peptide, named Hp91, whose sequence corresponds to a region within the endogenous protein HMGB1, activates dendritic cells (DCs) and acts as adjuvant in vivo by potentiating Thl -type antigen-specific immune responses. We analyzed the structure-function relationship of the Hp91 peptide to investigate the amino acids and structure responsible for immune responses. We found that the cysteine at position 16 of Hp91 enabled formation of reversible peptide dimmers, monomer and dimmer were compared for DC binding and activation. Stable monomers and dimers were generated using a maleimide conjugation reaction. The dimer showed enhanced ability to bind to and activate DCs. Furthermore, the C-terminal 9 amino acids of Hp91, named UC1018 were sufficient for DC binding and Circular dichroism showed that UC1018 assumes an alpha-helical structure. The ninemer peptide UC1018 induced more potent antigen-specific CTL responses in vivo as compared to Hp91 and it protected mice from tumor development when used in a prophylactic vaccine setting. We have identified a short alpha helical peptide that acts as potent adjuvant inducing protective immune responses in vivo.
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| 11. |
- Che, Karlhans F, et al.
(author)
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HIV-1 impairs in vitro priming of naïve T cells and gives rise to contact-dependent suppressor T cells
- 2010
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In: European Journal of Immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 40:8, s. 2248-2258
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Journal article (peer-reviewed)abstract
- Priming of T cells in lymphoid tissues of HIV-infected individuals occurs in the presence of HIV-1. DC in this milieu activate T cells and disseminate HIV-1 to newly activated T cells, the outcome of which may have serious implications in the development of optimal antiviral responses. We investigated the effects of HIV-1 on DC-naïve T-cell interactions using an allogeneic in vitro system. Our data demonstrate a dramatic decrease in the primary expansion of naïve T cells when cultured with HIV-1-exposed DC. CD4(+) and CD8(+) T cells showed enhanced expression of PD-1 and TRAIL, whereas CTLA-4 expression was observed on CD4(+) T cells. It is worth noting that T cells primed in the presence of HIV-1 suppressed priming of other naïve T cells in a contact-dependent manner. We identified PD-1, CTLA-4, and TRAIL pathways as responsible for this suppresion, as blocking these negative molecules restored T-cell proliferation to a higher degree. In conclusion, the presence of HIV-1 during DC priming produced cells with inhibitory effects on T-cell activation and proliferation, i.e. suppressor T cells, a mechanism that could contribute to the enhancement of HIV-1 pathogenesis.
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| 12. |
- Mc Conville, Jennifer R, 1978, et al.
(author)
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Decision Support for Redesigning Wastewater Treatment Technologies
- 2014
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In: Environmental Science & Technology. - : American Chemical Society (ACS). - 0013-936X .- 1520-5851. ; 48:20, s. 12238-12246
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Journal article (peer-reviewed)abstract
- This paper offers a methodology for structuring the design space for innovative process engineering technology development. The methodology is exemplified in the evaluation of a wide variety of treatment technologies for source-separated domestic wastewater within the scope of the Reinvent the Toilet Challenge. It offers a methodology for narrowing down the decision-making field based on a strict interpretation of treatment objectives for undiluted urine and dry feces and macroenvironmental factors (STEEPLED analysis) which influence decision criteria. Such an evaluation identifies promising paths for technology development such as focusing on space-saving processes or the need for more innovation in low-cost, energy-efficient urine treatment methods. Critical macroenvironmental factors, such as housing density, transportation infrastructure, and climate conditions were found to affect technology decisions regarding reactor volume, weight of outputs, energy consumption, atmospheric emissions, investment cost, and net revenue. The analysis also identified a number of qualitative factors that should be carefully weighed when pursuing technology development; such as availability of O&M resources, health and safety goals, and other ethical issues. Use of this methodology allows for coevolution of innovative technology within context constraints; however, for full-scale technology choices in the field, only very mature technologies can be evaluated.
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| 13. |
- Tjomsland, Vegard, et al.
(author)
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The Desmoplastic Stroma Plays an Essential Role in the Accumulation and Modulation of Infiltrated Immune Cells in Pancreatic Adenocarcinoma
- 2011
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In: Clinical & Developmental Immunology. - : Hindawi Publishing Corporation. - 1740-2522 .- 1740-2530. ; 2011:212810
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Journal article (peer-reviewed)abstract
- Tumor microenvironment is composed of tumor cells, fibroblasts, and infiltrating immune cells, which all work together and create an inflammatory environment favoring tumor progression. The present study aimed to investigate the role of the desmoplastic stroma in pancreatic ductal adenocarcinoma (PDAC) regarding expression of inflammatory factors and infiltration of immune cells and their impact on the clinical outcome. The PDAC tissues examined expressed significantly increased levels of immunomodulatory and chemotactic factors (IL-6, TGF beta, IDO, COX-2, CCL2, and CCL20) and immune cell-specific markers corresponding to macrophages, myeloid, and plasmacytoid dendritic cells (DCs) as compared to controls. Furthermore, short-time survivors had the lowest levels of DC markers. Immunostainings indicated that the different immune cells and inflammatory factors are mainly localized to the desmoplastic stroma. Therapies modulating the inflammatory tumor microenvironment to promote the attraction of DCs and differentiation of monocytes into functional DCs might improve the survival of PDAC patients.
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